LRRC47 — 66 ClinVar variants
All ClinVar germline LRRC47 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 63 flagged for review →
1 Likely benign · 65 Uncertain significance
Full LRRC47 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 63
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 45
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LRRC47 p.Arg381His Uncertain significance Multiple submitters
- LRRC47 p.Ala304Thr Uncertain significance Single submitter
- LRRC47 p.Ala391Val Uncertain significance Single submitter
- LRRC47 p.Arg192Gly Uncertain significance Single submitter
- LRRC47 p.Arg263Cys Uncertain significance Single submitter
- LRRC47 p.Arg271Cys Uncertain significance Single submitter
- LRRC47 p.Arg330Gln Uncertain significance Single submitter
- LRRC47 p.Arg330Trp Uncertain significance Single submitter
- LRRC47 p.Arg333Trp Uncertain significance Single submitter
- LRRC47 p.Arg381Cys Uncertain significance Single submitter
- LRRC47 p.Arg414Gln Uncertain significance Single submitter
- LRRC47 p.Asn189His Uncertain significance Single submitter
- LRRC47 p.Asn317Asp Uncertain significance Single submitter
- LRRC47 p.Asn445Ser Uncertain significance Single submitter
- LRRC47 p.Asn447His Uncertain significance Single submitter
- LRRC47 p.Asn447Thr Uncertain significance Single submitter
- LRRC47 p.Asp557His Uncertain significance Single submitter
- LRRC47 p.Gln156His Uncertain significance Single submitter
- LRRC47 p.Gln41Glu Uncertain significance Single submitter
- LRRC47 p.Gly39Asp Uncertain significance Single submitter
- LRRC47 p.Ile254Val Uncertain significance Single submitter
- LRRC47 p.Ile336Val Uncertain significance Single submitter
- LRRC47 p.Ile399Met Uncertain significance Single submitter
- LRRC47 p.Leu160Val Uncertain significance Single submitter
- LRRC47 p.Leu204Ile Uncertain significance Single submitter
- LRRC47 p.Leu227Phe Uncertain significance Single submitter
- LRRC47 p.Leu397Val Uncertain significance Single submitter
- LRRC47 p.Leu46Val Uncertain significance Single submitter
- LRRC47 p.Leu55Ser Uncertain significance Single submitter
- LRRC47 p.Pro225Ser Uncertain significance Single submitter
- LRRC47 p.Pro318Ala Uncertain significance Single submitter
- LRRC47 p.Pro462Gln Uncertain significance Single submitter
- LRRC47 p.Pro576Leu Uncertain significance Single submitter
- LRRC47 p.Pro66Leu Uncertain significance Single submitter
- LRRC47 p.Ser275Leu Uncertain significance Single submitter
- LRRC47 p.Ser358Leu Uncertain significance Single submitter
- LRRC47 p.Ser520Leu Uncertain significance Single submitter
- LRRC47 p.Thr161Ser Uncertain significance Single submitter
- LRRC47 p.Thr206Met Uncertain significance Single submitter
- LRRC47 p.Thr522Ala Uncertain significance Single submitter
- LRRC47 p.Tyr389Cys Uncertain significance Single submitter
- LRRC47 p.Val260Ile Uncertain significance Single submitter
- LRRC47 p.Val319Ile Uncertain significance Single submitter
- LRRC47 p.Val549Leu Uncertain significance Single submitter
- LRRC47 p.Val582Met Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- LRRC47 p.Ala409Val Uncertain significance Single submitter
- LRRC47 p.Ala454Val Uncertain significance Single submitter
- LRRC47 p.Arg281Trp Uncertain significance Single submitter
- LRRC47 p.Arg354Cys Uncertain significance Single submitter
- LRRC47 p.Arg414Trp Uncertain significance Single submitter
- LRRC47 p.Arg554Trp Uncertain significance Single submitter
- LRRC47 p.Glu171Lys Uncertain significance Single submitter
- LRRC47 p.Glu183Lys Uncertain significance Single submitter
- LRRC47 p.Glu243Lys Uncertain significance Single submitter
- LRRC47 p.Glu328Lys Uncertain significance Single submitter
- LRRC47 p.Gly338Arg Uncertain significance Single submitter
- LRRC47 p.Met503Ile Uncertain significance Single submitter
- LRRC47 p.Phe168Ser Uncertain significance Single submitter
- LRRC47 p.Pro50Arg Uncertain significance Single submitter
- LRRC47 p.Ser315Phe Uncertain significance Single submitter
- LRRC47 p.Thr251Ile Uncertain significance Single submitter
- LRRC47 p.Thr475Met Uncertain significance Single submitter
- LRRC47 p.Val555Met Uncertain significance Single submitter
All LRRC47 variants
Likely benign 1
- p.Val495Ile Single submitter
Uncertain significance 65
- p.Arg381His Multiple submitters ⚠
- p.Ala304Thr Single submitter ⚠
- p.Ala391Val Single submitter ⚠
- p.Ala409Val Single submitter ⚠
- p.Ala454Val Single submitter ⚠
- p.Arg192Gly Single submitter ⚠
- p.Arg263Cys Single submitter ⚠
- p.Arg271Cys Single submitter ⚠
- p.Arg281Trp Single submitter ⚠
- p.Arg330Gln Single submitter ⚠
- p.Arg330Trp Single submitter ⚠
- p.Arg333Trp Single submitter ⚠
- p.Arg354Cys Single submitter ⚠
- p.Arg381Cys Single submitter ⚠
- p.Arg414Gln Single submitter ⚠
- p.Arg414Trp Single submitter ⚠
- p.Arg554Trp Single submitter ⚠
- p.Asn189His Single submitter ⚠
- p.Asn317Asp Single submitter ⚠
- p.Asn445Ser Single submitter ⚠
- p.Asn447His Single submitter ⚠
- p.Asn447Thr Single submitter ⚠
- p.Asp557His Single submitter ⚠
- p.Gln156His Single submitter ⚠
- p.Gln41Glu Single submitter ⚠
- p.Glu171Lys Single submitter ⚠
- p.Glu183Lys Single submitter ⚠
- p.Glu243Lys Single submitter ⚠
- p.Glu328Lys Single submitter ⚠
- p.Gly338Arg Single submitter ⚠
- p.Gly349Glu Single submitter
- p.Gly39Asp Single submitter ⚠
- p.Ile254Val Single submitter ⚠
- p.Ile336Val Single submitter ⚠
- p.Ile399Met Single submitter ⚠
- p.Ile464Met Single submitter
- p.Leu160Val Single submitter ⚠
- p.Leu204Ile Single submitter ⚠
- p.Leu227Phe Single submitter ⚠
- p.Leu397Val Single submitter ⚠
- p.Leu46Val Single submitter ⚠
- p.Leu55Ser Single submitter ⚠
- p.Met503Ile Single submitter ⚠
- p.Phe168Ser Single submitter ⚠
- p.Pro225Ser Single submitter ⚠
- p.Pro318Ala Single submitter ⚠
- p.Pro462Gln Single submitter ⚠
- p.Pro50Arg Single submitter ⚠
- p.Pro576Leu Single submitter ⚠
- p.Pro66Leu Single submitter ⚠
- p.Ser275Leu Single submitter ⚠
- p.Ser315Phe Single submitter ⚠
- p.Ser358Leu Single submitter ⚠
- p.Ser520Leu Single submitter ⚠
- p.Thr161Ser Single submitter ⚠
- p.Thr206Met Single submitter ⚠
- p.Thr251Ile Single submitter ⚠
- p.Thr475Met Single submitter ⚠
- p.Thr522Ala Single submitter ⚠
- p.Tyr389Cys Single submitter ⚠
- p.Val260Ile Single submitter ⚠
- p.Val319Ile Single submitter ⚠
- p.Val549Leu Single submitter ⚠
- p.Val555Met Single submitter ⚠
- p.Val582Met Single submitter ⚠