LSG1 — 130 ClinVar variants
All ClinVar germline LSG1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 116 flagged for review →
2 Benign · 8 Likely benign · 120 Uncertain significance
Full LSG1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 116
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 92
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LSG1 p.Gly457Arg Uncertain significance Multiple submitters
- LSG1 p.Ala131Val Uncertain significance Single submitter
- LSG1 p.Ala288Pro Uncertain significance Single submitter
- LSG1 p.Ala346Ser Uncertain significance Single submitter
- LSG1 p.Ala611Gly Uncertain significance Single submitter
- LSG1 p.Ala627Glu Uncertain significance Single submitter
- LSG1 p.Ala633Val Uncertain significance Single submitter
- LSG1 p.Arg14Gln Uncertain significance Single submitter
- LSG1 p.Arg14Leu Uncertain significance Single submitter
- LSG1 p.Arg165His Uncertain significance Single submitter
- LSG1 p.Arg165Leu Uncertain significance Single submitter
- LSG1 p.Arg165Pro Uncertain significance Single submitter
- LSG1 p.Arg184Gln Uncertain significance Single submitter
- LSG1 p.Arg261Lys Uncertain significance Single submitter
- LSG1 p.Arg28Cys Uncertain significance Single submitter
- LSG1 p.Arg4Lys Uncertain significance Single submitter
- LSG1 p.Arg517Gln Uncertain significance Single submitter
- LSG1 p.Arg533Cys Uncertain significance Single submitter
- LSG1 p.Arg5Ser Uncertain significance Single submitter
- LSG1 p.Arg650Cys Uncertain significance Single submitter
- LSG1 p.Asn135His Uncertain significance Single submitter
- LSG1 p.Asn160Asp Uncertain significance Single submitter
- LSG1 p.Asn568Asp Uncertain significance Single submitter
- LSG1 p.Asn601Ser Uncertain significance Single submitter
- LSG1 p.Asp182Ala Uncertain significance Single submitter
- LSG1 p.Asp343Gly Uncertain significance Single submitter
- LSG1 p.Asp462Asn Uncertain significance Single submitter
- LSG1 p.Cys112Ser Uncertain significance Single submitter
- LSG1 p.Cys547Gly Uncertain significance Single submitter
- LSG1 p.Gln109Arg Uncertain significance Single submitter
- LSG1 p.Gln578His Uncertain significance Single submitter
- LSG1 p.Glu254Ala Uncertain significance Single submitter
- LSG1 p.Glu314Gly Uncertain significance Single submitter
- LSG1 p.Glu314Lys Uncertain significance Single submitter
- LSG1 p.Glu368Asp Uncertain significance Single submitter
- LSG1 p.Glu574Gly Uncertain significance Single submitter
- LSG1 p.Glu630Ala Uncertain significance Single submitter
- LSG1 p.Glu67Asp Uncertain significance Single submitter
- LSG1 p.Gly244Arg Uncertain significance Single submitter
- LSG1 p.Gly618Arg Uncertain significance Single submitter
- LSG1 p.Gly634Glu Uncertain significance Single submitter
- LSG1 p.Gly9Ser Uncertain significance Single submitter
- LSG1 p.His104Gln Uncertain significance Single submitter
- LSG1 p.His19Arg Uncertain significance Single submitter
- LSG1 p.His19Tyr Uncertain significance Single submitter
- LSG1 p.His270Pro Uncertain significance Single submitter
- LSG1 p.His27Arg Uncertain significance Single submitter
- LSG1 p.His280Gln Uncertain significance Single submitter
- LSG1 p.His285Arg Uncertain significance Single submitter
- LSG1 p.His548Arg Uncertain significance Single submitter
- LSG1 p.His655Gln Uncertain significance Single submitter
- LSG1 p.His655Tyr Uncertain significance Single submitter
- LSG1 p.Ile237Thr Uncertain significance Single submitter
- LSG1 p.Ile246Thr Uncertain significance Single submitter
- LSG1 p.Ile461Ser Uncertain significance Single submitter
- LSG1 p.Ile491Val Uncertain significance Single submitter
- LSG1 p.Ile591Thr Uncertain significance Single submitter
- LSG1 p.Leu210Pro Uncertain significance Single submitter
- LSG1 p.Leu510Phe Uncertain significance Single submitter
- LSG1 p.Leu565Ile Uncertain significance Single submitter
- LSG1 p.Leu63Arg Uncertain significance Single submitter
- LSG1 p.Lys205Met Uncertain significance Single submitter
- LSG1 p.Lys381Glu Uncertain significance Single submitter
- LSG1 p.Lys635Arg Uncertain significance Single submitter
- LSG1 p.Lys654Arg Uncertain significance Single submitter
- LSG1 p.Met520Thr Uncertain significance Single submitter
- LSG1 p.Met613Thr Uncertain significance Single submitter
- LSG1 p.Pro114Leu Uncertain significance Single submitter
- LSG1 p.Pro117Arg Uncertain significance Single submitter
- LSG1 p.Pro117Leu Uncertain significance Single submitter
- LSG1 p.Pro186Arg Uncertain significance Single submitter
- LSG1 p.Pro186Leu Uncertain significance Single submitter
- LSG1 p.Pro298Ser Uncertain significance Single submitter
- LSG1 p.Pro444Ala Uncertain significance Single submitter
- LSG1 p.Ser240Pro Uncertain significance Single submitter
- LSG1 p.Ser24Asn Uncertain significance Single submitter
- LSG1 p.Ser252Pro Uncertain significance Single submitter
- LSG1 p.Ser271Ala Uncertain significance Single submitter
- LSG1 p.Ser333Arg Uncertain significance Single submitter
- LSG1 p.Ser57Asn Uncertain significance Single submitter
- LSG1 p.Ser649Asn Uncertain significance Single submitter
- LSG1 p.Thr300Met Uncertain significance Single submitter
- LSG1 p.Thr511Lys Uncertain significance Single submitter
- LSG1 p.Thr606Ile Uncertain significance Single submitter
- LSG1 p.Thr65Ala Uncertain significance Single submitter
- LSG1 p.Tyr307Phe Uncertain significance Single submitter
- LSG1 p.Tyr394Cys Uncertain significance Single submitter
- LSG1 p.Val389Phe Uncertain significance Single submitter
- LSG1 p.Val442Met Uncertain significance Single submitter
- LSG1 p.Val474Ile Uncertain significance Single submitter
- LSG1 p.Val474Leu Uncertain significance Single submitter
- LSG1 p.Val592Ile Uncertain significance Single submitter
Predictors split 24
The independent predictors disagree with each other — read with care.
- LSG1 p.Ala451Thr Uncertain significance Single submitter
- LSG1 p.Arg141Cys Uncertain significance Single submitter
- LSG1 p.Arg141Ser Uncertain significance Single submitter
- LSG1 p.Arg159Gln Uncertain significance Single submitter
- LSG1 p.Arg222Gln Uncertain significance Single submitter
- LSG1 p.Arg47Cys Uncertain significance Single submitter
- LSG1 p.Arg47Gly Uncertain significance Single submitter
- LSG1 p.Arg502Gln Uncertain significance Single submitter
- LSG1 p.Arg650Gly Uncertain significance Single submitter
- LSG1 p.Arg650His Uncertain significance Single submitter
- LSG1 p.Asp657Val Uncertain significance Single submitter
- LSG1 p.Cys321Trp Uncertain significance Single submitter
- LSG1 p.Gln51Pro Uncertain significance Single submitter
- LSG1 p.Ile171Met Uncertain significance Single submitter
- LSG1 p.Ile403Val Uncertain significance Single submitter
- LSG1 p.Leu68Val Uncertain significance Single submitter
- LSG1 p.Leu78Phe Uncertain significance Single submitter
- LSG1 p.Pro504Ser Uncertain significance Single submitter
- LSG1 p.Ser456Ile Uncertain significance Single submitter
- LSG1 p.Ser649Arg Uncertain significance Single submitter
- LSG1 p.Thr123Ala Uncertain significance Single submitter
- LSG1 p.Trp45Leu Uncertain significance Single submitter
- LSG1 p.Tyr428Cys Uncertain significance Single submitter
- LSG1 p.Tyr487Cys Uncertain significance Single submitter
All LSG1 variants
Benign 2
- c.1544-11TC[2] Single submitter
- p.Thr493= Single submitter
Likely benign 8
- p.Arg347Trp Multiple submitters
- p.Asp202Glu Multiple submitters
- p.Ala627Val Single submitter
- p.Arg347Gln Single submitter
- p.Asp325= Single submitter
- p.Pro617= Single submitter
- p.Thr626Ala Single submitter
- p.Val471Ile Single submitter
Uncertain significance 120
- p.Gly457Arg Multiple submitters ⚠
- p.Ala131Val Single submitter ⚠
- p.Ala288Pro Single submitter ⚠
- p.Ala346Ser Single submitter ⚠
- p.Ala451Thr Single submitter ⚠
- p.Ala611Gly Single submitter ⚠
- p.Ala627Glu Single submitter ⚠
- p.Ala633Val Single submitter ⚠
- p.Arg115Lys Single submitter
- p.Arg141Cys Single submitter ⚠
- p.Arg141Ser Single submitter ⚠
- p.Arg14Gln Single submitter ⚠
- p.Arg14Leu Single submitter ⚠
- p.Arg159Gln Single submitter ⚠
- p.Arg165His Single submitter ⚠
- p.Arg165Leu Single submitter ⚠
- p.Arg165Pro Single submitter ⚠
- p.Arg184Gln Single submitter ⚠
- p.Arg222Gln Single submitter ⚠
- p.Arg261Lys Single submitter ⚠
- p.Arg28Cys Single submitter ⚠
- p.Arg47Cys Single submitter ⚠
- p.Arg47Gly Single submitter ⚠
- p.Arg4Lys Single submitter ⚠
- p.Arg502Gln Single submitter ⚠
- p.Arg517Gln Single submitter ⚠
- p.Arg533Cys Single submitter ⚠
- p.Arg5Ser Single submitter ⚠
- p.Arg650Cys Single submitter ⚠
- p.Arg650Gly Single submitter ⚠
- p.Arg650His Single submitter ⚠
- p.Asn135His Single submitter ⚠
- p.Asn160Asp Single submitter ⚠
- p.Asn568Asp Single submitter ⚠
- p.Asn601Ser Single submitter ⚠
- p.Asp182Ala Single submitter ⚠
- p.Asp343Gly Single submitter ⚠
- p.Asp462Asn Single submitter ⚠
- p.Asp657Val Single submitter ⚠
- p.Cys112Ser Single submitter ⚠
- p.Cys321Trp Single submitter ⚠
- p.Cys547Gly Single submitter ⚠
- p.Gln109Arg Single submitter ⚠
- p.Gln20Ter Single submitter
- p.Gln51Pro Single submitter ⚠
- p.Gln578His Single submitter ⚠
- p.Glu254Ala Single submitter ⚠
- p.Glu314Gly Single submitter ⚠
- p.Glu314Lys Single submitter ⚠
- p.Glu368Asp Single submitter ⚠
- p.Glu484Lys Single submitter
- p.Glu574Gly Single submitter ⚠
- p.Glu630Ala Single submitter ⚠
- p.Glu67Asp Single submitter ⚠
- p.Gly244Arg Single submitter ⚠
- p.Gly618Arg Single submitter ⚠
- p.Gly634Glu Single submitter ⚠
- p.Gly90Arg Single submitter
- p.Gly9Ser Single submitter ⚠
- p.His104Gln Single submitter ⚠
- p.His19Arg Single submitter ⚠
- p.His19Tyr Single submitter ⚠
- p.His270Pro Single submitter ⚠
- p.His27Arg Single submitter ⚠
- p.His280Gln Single submitter ⚠
- p.His285Arg Single submitter ⚠
- p.His548Arg Single submitter ⚠
- p.His655Gln Single submitter ⚠
- p.His655Tyr Single submitter ⚠
- p.Ile171Met Single submitter ⚠
- p.Ile237Thr Single submitter ⚠
- p.Ile246Thr Single submitter ⚠
- p.Ile403Val Single submitter ⚠
- p.Ile461Ser Single submitter ⚠
- p.Ile491Val Single submitter ⚠
- p.Ile591Thr Single submitter ⚠
- p.Leu210Pro Single submitter ⚠
- p.Leu510Phe Single submitter ⚠
- p.Leu565Ile Single submitter ⚠
- p.Leu63Arg Single submitter ⚠
- p.Leu68Val Single submitter ⚠
- p.Leu78Phe Single submitter ⚠
- p.Lys205Met Single submitter ⚠
- p.Lys381Glu Single submitter ⚠
- p.Lys635Arg Single submitter ⚠
- p.Lys654Arg Single submitter ⚠
- p.Met520Thr Single submitter ⚠
- p.Met613Thr Single submitter ⚠
- p.Pro114Leu Single submitter ⚠
- p.Pro117Arg Single submitter ⚠
- p.Pro117Leu Single submitter ⚠
- p.Pro186Arg Single submitter ⚠
- p.Pro186Leu Single submitter ⚠
- p.Pro298Ser Single submitter ⚠
- p.Pro444Ala Single submitter ⚠
- p.Pro504Ser Single submitter ⚠
- p.Ser240Pro Single submitter ⚠
- p.Ser24Asn Single submitter ⚠
- p.Ser252Pro Single submitter ⚠
- p.Ser271Ala Single submitter ⚠
- p.Ser333Arg Single submitter ⚠
- p.Ser456Ile Single submitter ⚠
- p.Ser57Asn Single submitter ⚠
- p.Ser649Arg Single submitter ⚠
- p.Ser649Asn Single submitter ⚠
- p.Thr123Ala Single submitter ⚠
- p.Thr300Met Single submitter ⚠
- p.Thr511Lys Single submitter ⚠
- p.Thr606Ile Single submitter ⚠
- p.Thr65Ala Single submitter ⚠
- p.Trp45Leu Single submitter ⚠
- p.Tyr307Phe Single submitter ⚠
- p.Tyr394Cys Single submitter ⚠
- p.Tyr428Cys Single submitter ⚠
- p.Tyr487Cys Single submitter ⚠
- p.Val389Phe Single submitter ⚠
- p.Val442Met Single submitter ⚠
- p.Val474Ile Single submitter ⚠
- p.Val474Leu Single submitter ⚠
- p.Val592Ile Single submitter ⚠