LSM11 — 57 ClinVar variants
All ClinVar germline LSM11 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 46 flagged for review →
1 Pathogenic · 1 Conflicting · 7 Likely benign · 48 Uncertain significance
Full LSM11 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 46
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LSM11 p.Arg216Gln Uncertain significance Multiple submitters
- LSM11 p.Ala104Gly Uncertain significance Single submitter
- LSM11 p.Ala127Val Uncertain significance Single submitter
- LSM11 p.Arg161His Uncertain significance Single submitter
- LSM11 p.Arg174Cys Uncertain significance Single submitter
- LSM11 p.Arg228Trp Uncertain significance Single submitter
- LSM11 p.Arg267Lys Uncertain significance Single submitter
- LSM11 p.Arg277Cys Uncertain significance Single submitter
- LSM11 p.Arg279Cys Uncertain significance Single submitter
- LSM11 p.Arg294Ser Uncertain significance Single submitter
- LSM11 p.Arg294Thr Uncertain significance Single submitter
- LSM11 p.Arg303Gln Uncertain significance Single submitter
- LSM11 p.Arg303Trp Uncertain significance Single submitter
- LSM11 p.Arg315Ser Uncertain significance Single submitter
- LSM11 p.Arg325Cys Uncertain significance Single submitter
- LSM11 p.Arg325His Uncertain significance Single submitter
- LSM11 p.Arg329Gln Uncertain significance Single submitter
- LSM11 p.Asn143His Uncertain significance Single submitter
- LSM11 p.Asp240Val Uncertain significance Single submitter
- LSM11 p.Asp269His Uncertain significance Single submitter
- LSM11 p.Gln111Lys Uncertain significance Single submitter
- LSM11 p.Glu108Ala Uncertain significance Single submitter
- LSM11 p.Glu152Lys Uncertain significance Single submitter
- LSM11 p.Gly135Ala Uncertain significance Single submitter
- LSM11 p.Gly273Ser Uncertain significance Single submitter
- LSM11 p.Gly322Val Uncertain significance Single submitter
- LSM11 p.His275Asp Uncertain significance Single submitter
- LSM11 p.His342Leu Uncertain significance Single submitter
- LSM11 p.Lys242Arg Uncertain significance Single submitter
- LSM11 p.Lys326Glu Uncertain significance Single submitter
- LSM11 p.Lys326Thr Uncertain significance Single submitter
- LSM11 p.Pro282Arg Uncertain significance Single submitter
- LSM11 p.Ser241Pro Uncertain significance Single submitter
- LSM11 p.Ser248Pro Uncertain significance Single submitter
- LSM11 p.Ser308Asn Uncertain significance Single submitter
- LSM11 p.Val182Ile Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- LSM11 p.Arg109Cys Uncertain significance Single submitter
- LSM11 p.Arg142His Uncertain significance Single submitter
- LSM11 p.Arg216Trp Uncertain significance Single submitter
- LSM11 p.Asn143Ser Uncertain significance Single submitter
- LSM11 p.Asp106Ala Uncertain significance Single submitter
- LSM11 p.Gly166Arg Uncertain significance Single submitter
- LSM11 p.Leu179Phe Uncertain significance Single submitter
- LSM11 p.Thr340Ile Uncertain significance Single submitter
- LSM11 p.Val338Ile Uncertain significance Single submitter
-
LSM11 p.Gly211Ser
Pathogenic
No assertion criteria
Aicardi-Goutieres syndrome 8
All LSM11 variants
Pathogenic 1
- p.Gly211Ser No assertion criteria Aicardi-Goutieres syndrome 8 ⚠
Conflicting classifications of pathogenicity 1
- p.Leu225= Single submitter
Likely benign 7
Uncertain significance 48
- p.Arg216Gln Multiple submitters ⚠
- c.*20G>A Single submitter
- p.Ala104Gly Single submitter ⚠
- p.Ala127Val Single submitter ⚠
- p.Arg109Cys Single submitter ⚠
- p.Arg142His Single submitter ⚠
- p.Arg161His Single submitter ⚠
- p.Arg174Cys Single submitter ⚠
- p.Arg216Trp Single submitter ⚠
- p.Arg228Trp Single submitter ⚠
- p.Arg267Lys Single submitter ⚠
- p.Arg277Cys Single submitter ⚠
- p.Arg279Cys Single submitter ⚠
- p.Arg294Ser Single submitter ⚠
- p.Arg294Thr Single submitter ⚠
- p.Arg303Gln Single submitter ⚠
- p.Arg303Trp Single submitter ⚠
- p.Arg315Ser Single submitter ⚠
- p.Arg325Cys Single submitter ⚠
- p.Arg325His Single submitter ⚠
- p.Arg329Gln Single submitter ⚠
- p.Asn143His Single submitter ⚠
- p.Asn143Ser Single submitter ⚠
- p.Asp106Ala Single submitter ⚠
- p.Asp240Val Single submitter ⚠
- p.Asp269His Single submitter ⚠
- p.Gln111Lys Single submitter ⚠
- p.Glu108Ala Single submitter ⚠
- p.Glu152Lys Single submitter ⚠
- p.Gly135Ala Single submitter ⚠
- p.Gly166Arg Single submitter ⚠
- p.Gly273Ser Single submitter ⚠
- p.Gly322Val Single submitter ⚠
- p.His275Asp Single submitter ⚠
- p.His342Leu Single submitter ⚠
- p.Leu179Phe Single submitter ⚠
- p.Lys242Arg Single submitter ⚠
- p.Lys326Glu Single submitter ⚠
- p.Lys326Thr Single submitter ⚠
- p.Lys330= Single submitter
- p.Lys332Glu Single submitter
- p.Pro282Arg Single submitter ⚠
- p.Ser241Pro Single submitter ⚠
- p.Ser248Pro Single submitter ⚠
- p.Ser308Asn Single submitter ⚠
- p.Thr340Ile Single submitter ⚠
- p.Val182Ile Single submitter ⚠
- p.Val338Ile Single submitter ⚠