LTK — 156 ClinVar variants
All ClinVar germline LTK variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 144 flagged for review →
2 Benign · 6 Likely benign · 148 Uncertain significance
Full LTK gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 144
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 110
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LTK p.Ala139Thr Uncertain significance Single submitter
- LTK p.Ala13Thr Uncertain significance Single submitter
- LTK p.Ala14Ser Uncertain significance Single submitter
- LTK p.Ala250Val Uncertain significance Single submitter
- LTK p.Ala305Val Uncertain significance Single submitter
- LTK p.Ala48Val Uncertain significance Single submitter
- LTK p.Ala515Val Uncertain significance Single submitter
- LTK p.Ala645Val Uncertain significance Single submitter
- LTK p.Ala646Thr Uncertain significance Single submitter
- LTK p.Arg138Gln Uncertain significance Single submitter
- LTK p.Arg184Gly Uncertain significance Single submitter
- LTK p.Arg203Cys Uncertain significance Single submitter
- LTK p.Arg203Leu Uncertain significance Single submitter
- LTK p.Arg243Trp Uncertain significance Single submitter
- LTK p.Arg258Leu Uncertain significance Single submitter
- LTK p.Arg30Gln Uncertain significance Single submitter
- LTK p.Arg376Gly Uncertain significance Single submitter
- LTK p.Arg376Pro Uncertain significance Single submitter
- LTK p.Arg377Ser Uncertain significance Single submitter
- LTK p.Arg618Trp Uncertain significance Single submitter
- LTK p.Arg647Trp Uncertain significance Single submitter
- LTK p.Arg658Pro Uncertain significance Single submitter
- LTK p.Arg682Gln Uncertain significance Single submitter
- LTK p.Arg754His Uncertain significance Single submitter
- LTK p.Arg767Cys Uncertain significance Single submitter
- LTK p.Arg776Cys Uncertain significance Single submitter
- LTK p.Arg78Gln Uncertain significance Single submitter
- LTK p.Arg816Thr Uncertain significance Single submitter
- LTK p.Asn509Ser Uncertain significance Single submitter
- LTK p.Asn859Lys Uncertain significance Single submitter
- LTK p.Asp43Glu Uncertain significance Single submitter
- LTK p.Asp681Asn Uncertain significance Single submitter
- LTK p.Asp743Ala Uncertain significance Single submitter
- LTK p.Asp87Asn Uncertain significance Single submitter
- LTK p.Cys780Tyr Uncertain significance Single submitter
- LTK p.Gln778Arg Uncertain significance Single submitter
- LTK p.Gln85Pro Uncertain significance Single submitter
- LTK p.Glu165Gln Uncertain significance Single submitter
- LTK p.Glu174Asp Uncertain significance Single submitter
- LTK p.Glu226Lys Uncertain significance Single submitter
- LTK p.Glu260Gly Uncertain significance Single submitter
- LTK p.Gly103Glu Uncertain significance Single submitter
- LTK p.Gly107Asp Uncertain significance Single submitter
- LTK p.Gly153Arg Uncertain significance Single submitter
- LTK p.Gly161Val Uncertain significance Single submitter
- LTK p.Gly170Ala Uncertain significance Single submitter
- LTK p.Gly170Arg Uncertain significance Single submitter
- LTK p.Gly246Val Uncertain significance Single submitter
- LTK p.Gly274Arg Uncertain significance Single submitter
- LTK p.Gly299Ser Uncertain significance Single submitter
- LTK p.Gly334Cys Uncertain significance Single submitter
- LTK p.Gly346Glu Uncertain significance Single submitter
- LTK p.Gly371Arg Uncertain significance Single submitter
- LTK p.Gly491Ser Uncertain significance Single submitter
- LTK p.Gly519Asp Uncertain significance Single submitter
- LTK p.Gly66Glu Uncertain significance Single submitter
- LTK p.Gly806Arg Uncertain significance Single submitter
- LTK p.Gly806Glu Uncertain significance Single submitter
- LTK p.His189Gln Uncertain significance Single submitter
- LTK p.His608Gln Uncertain significance Single submitter
- LTK p.His632Arg Uncertain significance Single submitter
- LTK p.His79Tyr Uncertain significance Single submitter
- LTK p.Ile17Val Uncertain significance Single submitter
- LTK p.Ile565Thr Uncertain significance Single submitter
- LTK p.Ile588Ser Uncertain significance Single submitter
- LTK p.Ile662Thr Uncertain significance Single submitter
- LTK p.Leu240Val Uncertain significance Single submitter
- LTK p.Leu490Phe Uncertain significance Single submitter
- LTK p.Leu513Phe Uncertain significance Single submitter
- LTK p.Leu532Pro Uncertain significance Single submitter
- LTK p.Leu532Val Uncertain significance Single submitter
- LTK p.Leu549Phe Uncertain significance Single submitter
- LTK p.Leu713Phe Uncertain significance Single submitter
- LTK p.Leu777Arg Uncertain significance Single submitter
- LTK p.Leu777Pro Uncertain significance Single submitter
- LTK p.Leu847Phe Uncertain significance Single submitter
- LTK p.Lys133Arg Uncertain significance Single submitter
- LTK p.Met560Val Uncertain significance Single submitter
- LTK p.Met617Thr Uncertain significance Single submitter
- LTK p.Met722Val Uncertain significance Single submitter
- LTK p.Phe218Ile Uncertain significance Single submitter
- LTK p.Phe28Leu Uncertain significance Single submitter
- LTK p.Phe521Ser Uncertain significance Single submitter
- LTK p.Pro199Ser Uncertain significance Single submitter
- LTK p.Pro252Arg Uncertain significance Single submitter
- LTK p.Pro282Ala Uncertain significance Single submitter
- LTK p.Pro41Ser Uncertain significance Single submitter
- LTK p.Pro465Thr Uncertain significance Single submitter
- LTK p.Pro552Ser Uncertain significance Single submitter
- LTK p.Pro607Ser Uncertain significance Single submitter
- LTK p.Pro749Ser Uncertain significance Single submitter
- LTK p.Ser137Leu Uncertain significance Single submitter
- LTK p.Ser183Phe Uncertain significance Single submitter
- LTK p.Ser195Arg Uncertain significance Single submitter
- LTK p.Ser21Asn Uncertain significance Single submitter
- LTK p.Ser259Trp Uncertain significance Single submitter
- LTK p.Ser51Ile Uncertain significance Single submitter
- LTK p.Ser702Thr Uncertain significance Single submitter
- LTK p.Ser718Leu Uncertain significance Single submitter
- LTK p.Thr511Ile Uncertain significance Single submitter
- LTK p.Thr584Asn Uncertain significance Single submitter
- LTK p.Thr64Ile Uncertain significance Single submitter
- LTK p.Thr704Ile Uncertain significance Single submitter
- LTK p.Trp10Cys Uncertain significance Single submitter
- LTK p.Trp68Leu Uncertain significance Single submitter
- LTK p.Val108Leu Uncertain significance Single submitter
- LTK p.Val732Met Uncertain significance Single submitter
- LTK p.Val736Ile Uncertain significance Single submitter
- LTK p.Val95Met Uncertain significance Single submitter
- LTK p.Val99Ala Uncertain significance Single submitter
Predictors split 34
The independent predictors disagree with each other — read with care.
- LTK p.Ala321Asp Uncertain significance Single submitter
- LTK p.Arg112Cys Uncertain significance Single submitter
- LTK p.Arg221Pro Uncertain significance Single submitter
- LTK p.Arg237Pro Uncertain significance Single submitter
- LTK p.Arg575Trp Uncertain significance Single submitter
- LTK p.Arg586Gly Uncertain significance Single submitter
- LTK p.Arg586His Uncertain significance Single submitter
- LTK p.Arg679Gly Uncertain significance Single submitter
- LTK p.Arg682Gly Uncertain significance Single submitter
- LTK p.Arg727His Uncertain significance Single submitter
- LTK p.Asp335Glu Uncertain significance Single submitter
- LTK p.Cys168Ser Uncertain significance Single submitter
- LTK p.Cys384Tyr Uncertain significance Single submitter
- LTK p.Cys550Arg Uncertain significance Single submitter
- LTK p.Cys653Tyr Uncertain significance Single submitter
- LTK p.Glu548Gln Uncertain significance Single submitter
- LTK p.Gly209Arg Uncertain significance Single submitter
- LTK p.Gly320Arg Uncertain significance Single submitter
- LTK p.His518Leu Uncertain significance Single submitter
- LTK p.Leu290Pro Uncertain significance Single submitter
- LTK p.Leu615Val Uncertain significance Single submitter
- LTK p.Leu685Phe Uncertain significance Single submitter
- LTK p.Leu787Arg Uncertain significance Single submitter
- LTK p.Phe315Leu Uncertain significance Single submitter
- LTK p.Phe639Tyr Uncertain significance Single submitter
- LTK p.Pro656Leu Uncertain significance Single submitter
- LTK p.Pro784Leu Uncertain significance Single submitter
- LTK p.Ser551Trp Uncertain significance Single submitter
- LTK p.Ser613Leu Uncertain significance Single submitter
- LTK p.Thr414Ile Uncertain significance Single submitter
- LTK p.Tyr672Phe Uncertain significance Single submitter
- LTK p.Val108Gly Uncertain significance Single submitter
- LTK p.Val541Ile Likely benign Single submitter
- LTK p.Val99Gly Uncertain significance Single submitter
All LTK variants
Benign 2
- p.Arg569Ser Multiple submitters
- p.Gln390= Single submitter
Likely benign 6
- p.Glu813Ter Multiple submitters
- p.Gln291Arg Single submitter
- p.Met793Val Single submitter
- p.Thr503= Single submitter
- p.Val413Ile Single submitter
- p.Val541Ile Single submitter ⚠
Uncertain significance 148
- p.Ala139Thr Single submitter ⚠
- p.Ala13Thr Single submitter ⚠
- p.Ala14Ser Single submitter ⚠
- p.Ala250Val Single submitter ⚠
- p.Ala305Val Single submitter ⚠
- p.Ala321Asp Single submitter ⚠
- p.Ala321Val Single submitter
- p.Ala48Val Single submitter ⚠
- p.Ala515Val Single submitter ⚠
- p.Ala645Val Single submitter ⚠
- p.Ala646Thr Single submitter ⚠
- p.Arg112Cys Single submitter ⚠
- p.Arg138Gln Single submitter ⚠
- p.Arg184Gly Single submitter ⚠
- p.Arg203Cys Single submitter ⚠
- p.Arg203Leu Single submitter ⚠
- p.Arg221Pro Single submitter ⚠
- p.Arg237Pro Single submitter ⚠
- p.Arg243Trp Single submitter ⚠
- p.Arg258Leu Single submitter ⚠
- p.Arg30Gln Single submitter ⚠
- p.Arg376Gly Single submitter ⚠
- p.Arg376Pro Single submitter ⚠
- p.Arg377Ser Single submitter ⚠
- p.Arg575Trp Single submitter ⚠
- p.Arg586Gly Single submitter ⚠
- p.Arg586His Single submitter ⚠
- p.Arg618Trp Single submitter ⚠
- p.Arg647Trp Single submitter ⚠
- p.Arg658Pro Single submitter ⚠
- p.Arg679Gly Single submitter ⚠
- p.Arg682Gln Single submitter ⚠
- p.Arg682Gly Single submitter ⚠
- p.Arg727His Single submitter ⚠
- p.Arg741Gln Single submitter
- p.Arg741Trp Single submitter
- p.Arg754His Single submitter ⚠
- p.Arg767Cys Single submitter ⚠
- p.Arg776Cys Single submitter ⚠
- p.Arg78Gln Single submitter ⚠
- p.Arg816Thr Single submitter ⚠
- p.Asn509Ser Single submitter ⚠
- p.Asn859Lys Single submitter ⚠
- p.Asp335Glu Single submitter ⚠
- p.Asp43Glu Single submitter ⚠
- p.Asp681Asn Single submitter ⚠
- p.Asp743Ala Single submitter ⚠
- p.Asp87Asn Single submitter ⚠
- p.Cys168Ser Single submitter ⚠
- p.Cys384Tyr Single submitter ⚠
- p.Cys550Arg Single submitter ⚠
- p.Cys653Tyr Single submitter ⚠
- p.Cys780Tyr Single submitter ⚠
- p.Gln778Arg Single submitter ⚠
- p.Gln85Pro Single submitter ⚠
- p.Glu165Gln Single submitter ⚠
- p.Glu174Asp Single submitter ⚠
- p.Glu226Lys Single submitter ⚠
- p.Glu260Gly Single submitter ⚠
- p.Glu548Gln Single submitter ⚠
- p.Gly103Glu Single submitter ⚠
- p.Gly107Asp Single submitter ⚠
- p.Gly153Arg Single submitter ⚠
- p.Gly161Val Single submitter ⚠
- p.Gly170Ala Single submitter ⚠
- p.Gly170Arg Single submitter ⚠
- p.Gly209Arg Single submitter ⚠
- p.Gly246Val Single submitter ⚠
- p.Gly274Arg Single submitter ⚠
- p.Gly299Ser Single submitter ⚠
- p.Gly320Arg Single submitter ⚠
- p.Gly334Cys Single submitter ⚠
- p.Gly346Glu Single submitter ⚠
- p.Gly371Arg Single submitter ⚠
- p.Gly491Ser Single submitter ⚠
- p.Gly519Asp Single submitter ⚠
- p.Gly66Glu Single submitter ⚠
- p.Gly806Arg Single submitter ⚠
- p.Gly806Glu Single submitter ⚠
- p.His189Gln Single submitter ⚠
- p.His383Gln Single submitter
- p.His518Leu Single submitter ⚠
- p.His608Gln Single submitter ⚠
- p.His632Arg Single submitter ⚠
- p.His79Tyr Single submitter ⚠
- p.Ile17Val Single submitter ⚠
- p.Ile565Thr Single submitter ⚠
- p.Ile588Ser Single submitter ⚠
- p.Ile662Thr Single submitter ⚠
- p.Leu240Val Single submitter ⚠
- p.Leu290Pro Single submitter ⚠
- p.Leu490Phe Single submitter ⚠
- p.Leu513Phe Single submitter ⚠
- p.Leu532Pro Single submitter ⚠
- p.Leu532Val Single submitter ⚠
- p.Leu549Phe Single submitter ⚠
- p.Leu615Val Single submitter ⚠
- p.Leu685Phe Single submitter ⚠
- p.Leu713Phe Single submitter ⚠
- p.Leu777Arg Single submitter ⚠
- p.Leu777Pro Single submitter ⚠
- p.Leu787Arg Single submitter ⚠
- p.Leu787Pro Single submitter
- p.Leu847Phe Single submitter ⚠
- p.Lys133Arg Single submitter ⚠
- p.Met560Val Single submitter ⚠
- p.Met617Thr Single submitter ⚠
- p.Met722Val Single submitter ⚠
- p.Phe218Ile Single submitter ⚠
- p.Phe28Leu Single submitter ⚠
- p.Phe315Leu Single submitter ⚠
- p.Phe521Ser Single submitter ⚠
- p.Phe639Tyr Single submitter ⚠
- p.Pro199Ser Single submitter ⚠
- p.Pro252Arg Single submitter ⚠
- p.Pro282Ala Single submitter ⚠
- p.Pro41Ser Single submitter ⚠
- p.Pro465Thr Single submitter ⚠
- p.Pro552Ser Single submitter ⚠
- p.Pro607Ser Single submitter ⚠
- p.Pro656Leu Single submitter ⚠
- p.Pro749Ser Single submitter ⚠
- p.Pro784Leu Single submitter ⚠
- p.Ser137Leu Single submitter ⚠
- p.Ser183Phe Single submitter ⚠
- p.Ser195Arg Single submitter ⚠
- p.Ser21Asn Single submitter ⚠
- p.Ser259Trp Single submitter ⚠
- p.Ser51Ile Single submitter ⚠
- p.Ser551Trp Single submitter ⚠
- p.Ser613Leu Single submitter ⚠
- p.Ser702Thr Single submitter ⚠
- p.Ser718Leu Single submitter ⚠
- p.Thr414Ile Single submitter ⚠
- p.Thr511Ile Single submitter ⚠
- p.Thr584Asn Single submitter ⚠
- p.Thr64Ile Single submitter ⚠
- p.Thr704Ile Single submitter ⚠
- p.Trp10Cys Single submitter ⚠
- p.Trp68Leu Single submitter ⚠
- p.Tyr672Phe Single submitter ⚠
- p.Val108Gly Single submitter ⚠
- p.Val108Leu Single submitter ⚠
- p.Val732Met Single submitter ⚠
- p.Val736Ile Single submitter ⚠
- p.Val95Met Single submitter ⚠
- p.Val99Ala Single submitter ⚠
- p.Val99Gly Single submitter ⚠