Sugi Variant

Sugi Variant/MAOA

MAOA — 254 ClinVar variants

All ClinVar germline MAOA variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 124 flagged for review →

7 Pathogenic · 1 Pathogenic/Likely pathogenic · 12 Likely pathogenic · 13 Conflicting · 8 Benign · 3 Benign/Likely benign · 75 Likely benign · 135 Uncertain significance

Full MAOA gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 124

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 8

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 86

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 29

The independent predictors disagree with each other — read with care.

All MAOA variants

Pathogenic 7

Pathogenic/Likely pathogenic 1

Likely pathogenic 12

Conflicting classifications of pathogenicity 13

Benign 8

Benign/Likely benign 3

Likely benign 75

Uncertain significance 135