MAOB — 54 ClinVar variants
All ClinVar germline MAOB variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
4 Benign · 7 Likely benign · 43 Uncertain significance
Full MAOB gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MAOB p.Ala161Ser Uncertain significance Multiple submitters
- MAOB p.Ala322Thr Uncertain significance Single submitter
- MAOB p.Arg100Ser Uncertain significance Single submitter
- MAOB p.Arg242Lys Uncertain significance Single submitter
- MAOB p.Arg282Lys Uncertain significance Single submitter
- MAOB p.Arg36Trp Uncertain significance Single submitter
- MAOB p.Asp124Ala Uncertain significance Single submitter
- MAOB p.Asp153Glu Uncertain significance Single submitter
- MAOB p.Glu179Gln Uncertain significance Single submitter
- MAOB p.Glu358Gln Uncertain significance Single submitter
- MAOB p.Glu366Asp Uncertain significance Single submitter
- MAOB p.Glu74Asp Uncertain significance Single submitter
- MAOB p.Gly41Ser Uncertain significance Single submitter
- MAOB p.His115Arg Uncertain significance Single submitter
- MAOB p.Leu155Phe Uncertain significance Single submitter
- MAOB p.Leu167Val Uncertain significance Single submitter
- MAOB p.Leu22Pro Uncertain significance Single submitter
- MAOB p.Leu372Met Uncertain significance Single submitter
- MAOB p.Lys50Asn Uncertain significance Single submitter
- MAOB p.Met281Thr Uncertain significance Single submitter
- MAOB p.Met341Thr Uncertain significance Single submitter
- MAOB p.Met454Thr Uncertain significance Single submitter
- MAOB p.Phe509Cys Uncertain significance Single submitter
- MAOB p.Ser131Arg Uncertain significance Single submitter
- MAOB p.Ser214Thr Uncertain significance Single submitter
- MAOB p.Ser59Ala Uncertain significance Single submitter
- MAOB p.Thr166Ala Uncertain significance Single submitter
- MAOB p.Thr196Ala Uncertain significance Single submitter
- MAOB p.Thr196Arg Uncertain significance Single submitter
- MAOB p.Thr505Met Uncertain significance Single submitter
- MAOB p.Val260Met Uncertain significance Single submitter
- MAOB p.Val289Leu Uncertain significance Single submitter
- MAOB p.Val31Ile Uncertain significance Single submitter
- MAOB p.Val489Met Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- MAOB p.Arg220Gln Uncertain significance Single submitter
- MAOB p.Arg288His Uncertain significance Single submitter
- MAOB p.Asn145Asp Uncertain significance Single submitter
- MAOB p.Asp330Asn Uncertain significance Single submitter
- MAOB p.Leu69Phe Uncertain significance Single submitter
- MAOB p.Phe103Ser Uncertain significance Single submitter
- MAOB p.Thr249Ala Uncertain significance Single submitter
- MAOB p.Trp107Cys Uncertain significance Single submitter
All MAOB variants
Benign 4
- c.1410+8A>G Single submitter
- p.Phe481= Single submitter
- p.Pro134= Single submitter
- p.Pro279= Single submitter
Likely benign 7
- c.1138-9A>G Single submitter
- p.Gln475Leu Single submitter
- p.Ile264Val Single submitter
- p.Ile477= Single submitter
- p.Leu28= Single submitter
- p.Leu482Met Single submitter
- p.Ser488= Single submitter
Uncertain significance 43
- p.Ala161Ser Multiple submitters ⚠
- p.Ala322Thr Single submitter ⚠
- p.Arg100Ser Single submitter ⚠
- p.Arg220Gln Single submitter ⚠
- p.Arg242Lys Single submitter ⚠
- p.Arg282Lys Single submitter ⚠
- p.Arg288His Single submitter ⚠
- p.Arg36Trp Single submitter ⚠
- p.Asn145Asp Single submitter ⚠
- p.Asp124Ala Single submitter ⚠
- p.Asp153Glu Single submitter ⚠
- p.Asp330Asn Single submitter ⚠
- p.Glu179Gln Single submitter ⚠
- p.Glu358Gln Single submitter ⚠
- p.Glu366Asp Single submitter ⚠
- p.Glu74Asp Single submitter ⚠
- p.Gly41Ser Single submitter ⚠
- p.Gly455Trp Single submitter
- p.His115Arg Single submitter ⚠
- p.Leu155Phe Single submitter ⚠
- p.Leu167Val Single submitter ⚠
- p.Leu22Pro Single submitter ⚠
- p.Leu372Met Single submitter ⚠
- p.Leu69Phe Single submitter ⚠
- p.Lys50Asn Single submitter ⚠
- p.Met281Thr Single submitter ⚠
- p.Met341Thr Single submitter ⚠
- p.Met454Thr Single submitter ⚠
- p.Phe103Ser Single submitter ⚠
- p.Phe509Cys Single submitter ⚠
- p.Ser131Arg Single submitter ⚠
- p.Ser214Thr Single submitter ⚠
- p.Ser59Ala Single submitter ⚠
- p.Thr166Ala Single submitter ⚠
- p.Thr196Ala Single submitter ⚠
- p.Thr196Arg Single submitter ⚠
- p.Thr249Ala Single submitter ⚠
- p.Thr505Met Single submitter ⚠
- p.Trp107Cys Single submitter ⚠
- p.Val260Met Single submitter ⚠
- p.Val289Leu Single submitter ⚠
- p.Val31Ile Single submitter ⚠
- p.Val489Met Single submitter ⚠