MAP3K10 — 137 ClinVar variants

All ClinVar germline MAP3K10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 126 flagged for review →

1 Benign · 5 Likely benign · 131 Uncertain significance

Full MAP3K10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 126

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 106

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 20

The independent predictors disagree with each other — read with care.

All MAP3K10 variants

Benign 1

c.1188+7G>A Single submitter

Likely benign 5

p.Arg906Gln Single submitter
p.Cys143Arg Single submitter
p.Gly471Ser Single submitter
p.Phe249= Single submitter
p.Val927Met Single submitter

Uncertain significance 131

p.Ala240Thr Single submitter ⚠
p.Ala263Thr Single submitter ⚠
p.Ala364Thr Single submitter ⚠
p.Ala488Thr Single submitter ⚠
p.Ala603Thr Single submitter ⚠
p.Ala648Val Single submitter ⚠
p.Ala658Thr Single submitter ⚠
p.Ala661Thr Single submitter ⚠
p.Ala667Val Single submitter ⚠
p.Ala684Thr Single submitter ⚠
p.Ala772Gly Single submitter ⚠
p.Ala773Thr Single submitter ⚠
p.Ala82Ser Single submitter ⚠
p.Ala867Ser Single submitter ⚠
p.Ala867Val Single submitter ⚠
p.Arg178Gln Single submitter ⚠
p.Arg304His Single submitter ⚠
p.Arg334His Single submitter ⚠
p.Arg356Trp Single submitter ⚠
p.Arg39Ser Single submitter ⚠
p.Arg420Gln Single submitter ⚠
p.Arg421Gln Single submitter ⚠
p.Arg495Gln Single submitter ⚠
p.Arg495Trp Single submitter ⚠
p.Arg540Cys Single submitter ⚠
p.Arg569Trp Single submitter ⚠
p.Arg668Trp Single submitter ⚠
p.Arg704Cys Single submitter ⚠
p.Arg716Cys Single submitter ⚠
p.Arg731Cys Single submitter ⚠
p.Arg731Leu Single submitter ⚠
p.Arg807His Single submitter ⚠
p.Arg850Cys Single submitter ⚠
p.Arg857His Single submitter ⚠
p.Arg869Cys Single submitter ⚠
p.Arg869His Single submitter ⚠
p.Arg877Cys Single submitter ⚠
p.Arg888Gln Single submitter
p.Arg893His Single submitter ⚠
p.Arg906Trp Single submitter ⚠
p.Asn236Asp Single submitter ⚠
p.Asn238Ser Single submitter ⚠
p.Asp341Glu Single submitter ⚠
p.Asp389Gly Single submitter ⚠
p.Asp499Asn Single submitter ⚠
p.Asp672Tyr Single submitter ⚠
p.Asp733Tyr Single submitter ⚠
p.Asp733Val Single submitter ⚠
p.Asp754Gly Single submitter
p.Asp860His Single submitter ⚠
p.Cys671Trp Single submitter ⚠
p.Gln362His Single submitter ⚠
p.Gln702Pro Single submitter ⚠
p.Glu101Lys Single submitter ⚠
p.Glu102Asp Single submitter ⚠
p.Glu102Lys Single submitter ⚠
p.Glu145Lys Single submitter ⚠
p.Glu416Lys Single submitter ⚠
p.Glu448Ala Single submitter ⚠
p.Glu547Lys Single submitter ⚠
p.Glu643Lys Single submitter ⚠
p.Glu653Ala Single submitter ⚠
p.Glu653Asp Single submitter ⚠
p.Glu653Gly Single submitter ⚠
p.Glu841Gly Single submitter ⚠
p.Gly188Ala Single submitter
p.Gly351Ser Single submitter ⚠
p.Gly551Arg Single submitter ⚠
p.Gly552Ser Single submitter ⚠
p.Gly556Glu Single submitter ⚠
p.Gly666Cys Single submitter ⚠
p.Gly699Val Single submitter ⚠
p.Gly832Arg Single submitter ⚠
p.Gly86Asp Single submitter ⚠
p.Gly876Asp Single submitter ⚠
p.Gly952Ser Single submitter ⚠
p.His845Arg Single submitter ⚠
p.Ile226Val Single submitter ⚠
p.Ile910Met Single submitter ⚠
p.Leu896Ser Single submitter ⚠
p.Lys598Arg Single submitter ⚠
p.Met612Leu Single submitter ⚠
p.Met934Val Single submitter ⚠
p.Met936Thr Single submitter ⚠
p.Phe95Leu Single submitter ⚠
p.Pro167Leu Single submitter ⚠
p.Pro167Thr Single submitter ⚠
p.Pro193Ala Single submitter ⚠
p.Pro504Leu Single submitter ⚠
p.Pro504Thr Single submitter ⚠
p.Pro511Ser Single submitter ⚠
p.Pro626Ser Single submitter ⚠
p.Pro633Leu Single submitter ⚠
p.Pro651Gln Single submitter ⚠
p.Pro656Ala Single submitter ⚠
p.Pro656Leu Single submitter ⚠
p.Pro718Ser Single submitter ⚠
p.Pro785Leu Single submitter ⚠
p.Pro793Ser Single submitter ⚠
p.Pro839Leu Single submitter ⚠
p.Pro878Ser Single submitter
p.Pro894Ser Single submitter ⚠
p.Pro898Ala Single submitter ⚠
p.Pro916Thr Single submitter ⚠
p.Pro919Leu Single submitter ⚠
p.Pro946Ser Single submitter ⚠
p.Ser562Asn Single submitter ⚠
p.Ser562Thr Single submitter ⚠
p.Ser631Leu Single submitter ⚠
p.Ser657Pro Single submitter ⚠
p.Ser775Ala Single submitter ⚠
p.Ser775Cys Single submitter ⚠
p.Ser788Pro Single submitter ⚠
p.Thr298Met Single submitter ⚠
p.Thr327Pro Single submitter ⚠
p.Thr655Pro Single submitter ⚠
p.Thr745Ala Single submitter ⚠
p.Thr745Ser Single submitter ⚠
p.Thr816Lys Single submitter ⚠
p.Thr907Ile Single submitter
p.Trp652Gly Single submitter ⚠
p.Trp652Ser Single submitter ⚠
p.Val106Leu Single submitter ⚠
p.Val203Met Single submitter ⚠
p.Val434Met Single submitter ⚠
p.Val521Met Single submitter ⚠
p.Val52Gly Single submitter ⚠
p.Val68Met Single submitter ⚠
p.Val691Met Single submitter ⚠
p.Val815Leu Single submitter ⚠
p.Val821Ala Single submitter ⚠