Sugi Variant

Sugi Variant/MAP3K7

MAP3K7 — 393 ClinVar variants

All ClinVar germline MAP3K7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 165 flagged for review →

10 Pathogenic · 3 Pathogenic/Likely pathogenic · 14 Likely pathogenic · 18 Conflicting · 37 Benign · 5 Benign/Likely benign · 114 Likely benign · 192 Uncertain significance

Full MAP3K7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 165

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 13

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 112

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 39

The independent predictors disagree with each other — read with care.

All MAP3K7 variants

Pathogenic 10

Pathogenic/Likely pathogenic 3

Likely pathogenic 14

Conflicting classifications of pathogenicity 18

Benign 37

Benign/Likely benign 5

Likely benign 114

Uncertain significance 192