MAP4K1 — 79 ClinVar variants
All ClinVar germline MAP4K1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 68 flagged for review →
7 Likely benign · 72 Uncertain significance
Full MAP4K1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 68
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 64
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MAP4K1 p.Ala246Ser Uncertain significance Single submitter
- MAP4K1 p.Ala313Pro Uncertain significance Single submitter
- MAP4K1 p.Ala452Ser Uncertain significance Single submitter
- MAP4K1 p.Ala452Thr Uncertain significance Single submitter
- MAP4K1 p.Ala452Val Uncertain significance Single submitter
- MAP4K1 p.Ala485Ser Uncertain significance Single submitter
- MAP4K1 p.Ala609Val Uncertain significance Single submitter
- MAP4K1 p.Ala661Gly Uncertain significance Single submitter
- MAP4K1 p.Arg281Gln Uncertain significance Single submitter
- MAP4K1 p.Arg323His Uncertain significance Single submitter
- MAP4K1 p.Arg337Gln Uncertain significance Single submitter
- MAP4K1 p.Arg357Cys Uncertain significance Single submitter
- MAP4K1 p.Arg357His Uncertain significance Single submitter
- MAP4K1 p.Arg404Cys Uncertain significance Single submitter
- MAP4K1 p.Arg427Gln Uncertain significance Single submitter
- MAP4K1 p.Arg438Cys Uncertain significance Single submitter
- MAP4K1 p.Arg692Cys Uncertain significance Single submitter
- MAP4K1 p.Arg70Gln Uncertain significance Single submitter
- MAP4K1 p.Arg793His Uncertain significance Single submitter
- MAP4K1 p.Asp379Asn Uncertain significance Single submitter
- MAP4K1 p.Asp417His Uncertain significance Single submitter
- MAP4K1 p.Asp53Gly Uncertain significance Single submitter
- MAP4K1 p.Asp779Val Uncertain significance Single submitter
- MAP4K1 p.Asp7His Uncertain significance Single submitter
- MAP4K1 p.Cys90Phe Uncertain significance Single submitter
- MAP4K1 p.Gln512His Uncertain significance Single submitter
- MAP4K1 p.Gln530Lys Uncertain significance Single submitter
- MAP4K1 p.Glu306Lys Uncertain significance Single submitter
- MAP4K1 p.Glu391Lys Uncertain significance Single submitter
- MAP4K1 p.Gly295Arg Uncertain significance Single submitter
- MAP4K1 p.Gly412Arg Uncertain significance Single submitter
- MAP4K1 p.Gly620Cys Uncertain significance Single submitter
- MAP4K1 p.Gly709Arg Uncertain significance Single submitter
- MAP4K1 p.Gly79Glu Uncertain significance Single submitter
- MAP4K1 p.His449Tyr Uncertain significance Single submitter
- MAP4K1 p.Ile300Met Uncertain significance Single submitter
- MAP4K1 p.Ile300Phe Uncertain significance Single submitter
- MAP4K1 p.Ile300Thr Uncertain significance Single submitter
- MAP4K1 p.Leu496Arg Uncertain significance Single submitter
- MAP4K1 p.Leu785Met Uncertain significance Single submitter
- MAP4K1 p.Met339Val Uncertain significance Single submitter
- MAP4K1 p.Met414Lys Uncertain significance Single submitter
- MAP4K1 p.Met703Thr Uncertain significance Single submitter
- MAP4K1 p.Pro277Ser Uncertain significance Single submitter
- MAP4K1 p.Pro437Ser Uncertain significance Single submitter
- MAP4K1 p.Pro441Ser Uncertain significance Single submitter
- MAP4K1 p.Pro443Arg Uncertain significance Single submitter
- MAP4K1 p.Pro581Leu Uncertain significance Single submitter
- MAP4K1 p.Pro666Thr Uncertain significance Single submitter
- MAP4K1 p.Pro798Ala Uncertain significance Single submitter
- MAP4K1 p.Pro798His Uncertain significance Single submitter
- MAP4K1 p.Ser366Thr Uncertain significance Single submitter
- MAP4K1 p.Ser405Phe Uncertain significance Single submitter
- MAP4K1 p.Ser668Cys Uncertain significance Single submitter
- MAP4K1 p.Ser704Arg Uncertain significance Single submitter
- MAP4K1 p.Ser797Phe Uncertain significance Single submitter
- MAP4K1 p.Thr355Ala Uncertain significance Single submitter
- MAP4K1 p.Thr533Met Uncertain significance Single submitter
- MAP4K1 p.Thr629Ala Uncertain significance Single submitter
- MAP4K1 p.Thr789Asn Uncertain significance Single submitter
- MAP4K1 p.Thr791Ile Uncertain significance Single submitter
- MAP4K1 p.Val183Ala Uncertain significance Single submitter
- MAP4K1 p.Val677Met Uncertain significance Single submitter
- MAP4K1 p.Val759Ala Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All MAP4K1 variants
Likely benign 7
- p.Arg438His Single submitter
- p.Gly665Arg Single submitter
- p.Pro734= Single submitter
- p.Ser377= Single submitter
- p.Ser737= Single submitter
- p.Thr501= Single submitter
- p.Val802Met Single submitter
Uncertain significance 72
- p.Ala246Ser Single submitter ⚠
- p.Ala313Pro Single submitter ⚠
- p.Ala452Ser Single submitter ⚠
- p.Ala452Thr Single submitter ⚠
- p.Ala452Val Single submitter ⚠
- p.Ala485Ser Single submitter ⚠
- p.Ala609Val Single submitter ⚠
- p.Ala661Gly Single submitter ⚠
- p.Arg119Gln Single submitter ⚠
- p.Arg236Ter Single submitter
- p.Arg281Gln Single submitter ⚠
- p.Arg323His Single submitter ⚠
- p.Arg337Gln Single submitter ⚠
- p.Arg357Cys Single submitter ⚠
- p.Arg357His Single submitter ⚠
- p.Arg404Cys Single submitter ⚠
- p.Arg427Gln Single submitter ⚠
- p.Arg438Cys Single submitter ⚠
- p.Arg497Trp Single submitter ⚠
- p.Arg692Cys Single submitter ⚠
- p.Arg70Gln Single submitter ⚠
- p.Arg793His Single submitter ⚠
- p.Asn146Lys Single submitter ⚠
- p.Asp379Asn Single submitter ⚠
- p.Asp417His Single submitter ⚠
- p.Asp53Gly Single submitter ⚠
- p.Asp779Val Single submitter ⚠
- p.Asp7His Single submitter ⚠
- p.Cys90Phe Single submitter ⚠
- p.Gln512His Single submitter ⚠
- p.Gln530Lys Single submitter ⚠
- p.Glu306Lys Single submitter ⚠
- p.Glu391Lys Single submitter ⚠
- p.Gly295Arg Single submitter ⚠
- p.Gly412Arg Single submitter ⚠
- p.Gly620Cys Single submitter ⚠
- p.Gly709Arg Single submitter ⚠
- p.Gly79Glu Single submitter ⚠
- p.His449Tyr Single submitter ⚠
- p.Ile300Met Single submitter ⚠
- p.Ile300Phe Single submitter ⚠
- p.Ile300Thr Single submitter ⚠
- p.Ile63Met Single submitter
- p.Leu496Arg Single submitter ⚠
- p.Leu785Met Single submitter ⚠
- p.Met339Val Single submitter ⚠
- p.Met414Lys Single submitter ⚠
- p.Met703Thr Single submitter ⚠
- p.Pro277Ser Single submitter ⚠
- p.Pro437Ser Single submitter ⚠
- p.Pro441Ser Single submitter ⚠
- p.Pro443Arg Single submitter ⚠
- p.Pro581Leu Single submitter ⚠
- p.Pro587Leu Single submitter
- p.Pro666Thr Single submitter ⚠
- p.Pro798Ala Single submitter ⚠
- p.Pro798His Single submitter ⚠
- p.Ser366Thr Single submitter ⚠
- p.Ser405Phe Single submitter ⚠
- p.Ser668Cys Single submitter ⚠
- p.Ser704Arg Single submitter ⚠
- p.Ser797Phe Single submitter ⚠
- p.Thr355Ala Single submitter ⚠
- p.Thr533Met Single submitter ⚠
- p.Thr629Ala Single submitter ⚠
- p.Thr68Ile Single submitter ⚠
- p.Thr789Asn Single submitter ⚠
- p.Thr791Ile Single submitter ⚠
- p.Val183Ala Single submitter ⚠
- p.Val274fs Single submitter
- p.Val677Met Single submitter ⚠
- p.Val759Ala Single submitter ⚠