MAPK15 — 124 ClinVar variants
All ClinVar germline MAPK15 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 104 flagged for review →
1 Benign · 9 Likely benign · 114 Uncertain significance
Full MAPK15 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 104
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 88
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MAPK15 p.Arg496Trp Uncertain significance Multiple submitters
- MAPK15 p.Ala179Thr Uncertain significance Single submitter
- MAPK15 p.Ala251Val Uncertain significance Single submitter
- MAPK15 p.Ala40Val Uncertain significance Single submitter
- MAPK15 p.Ala436Ser Uncertain significance Single submitter
- MAPK15 p.Ala436Val Uncertain significance Single submitter
- MAPK15 p.Ala514Thr Uncertain significance Single submitter
- MAPK15 p.Arg104Gln Uncertain significance Single submitter
- MAPK15 p.Arg136Gly Uncertain significance Single submitter
- MAPK15 p.Arg136Pro Uncertain significance Single submitter
- MAPK15 p.Arg213Gln Uncertain significance Single submitter
- MAPK15 p.Arg213Leu Uncertain significance Single submitter
- MAPK15 p.Arg250Cys Uncertain significance Single submitter
- MAPK15 p.Arg262Gln Uncertain significance Single submitter
- MAPK15 p.Arg262Leu Uncertain significance Single submitter
- MAPK15 p.Arg262Pro Uncertain significance Single submitter
- MAPK15 p.Arg283Gln Uncertain significance Single submitter
- MAPK15 p.Arg292Pro Uncertain significance Single submitter
- MAPK15 p.Arg292Trp Uncertain significance Single submitter
- MAPK15 p.Arg316Gln Uncertain significance Single submitter
- MAPK15 p.Arg323Trp Uncertain significance Single submitter
- MAPK15 p.Arg33Pro Uncertain significance Single submitter
- MAPK15 p.Arg380Lys Uncertain significance Single submitter
- MAPK15 p.Arg470Gly Uncertain significance Single submitter
- MAPK15 p.Arg475Gln Uncertain significance Single submitter
- MAPK15 p.Arg490Trp Uncertain significance Single submitter
- MAPK15 p.Arg499Gln Uncertain significance Single submitter
- MAPK15 p.Asp200Tyr Uncertain significance Single submitter
- MAPK15 p.Asp312Asn Uncertain significance Single submitter
- MAPK15 p.Asp374Asn Uncertain significance Single submitter
- MAPK15 p.Asp374Tyr Uncertain significance Single submitter
- MAPK15 p.Gln120His Uncertain significance Single submitter
- MAPK15 p.Gln391Arg Uncertain significance Single submitter
- MAPK15 p.Gln523Leu Uncertain significance Single submitter
- MAPK15 p.Glu187Lys Uncertain significance Single submitter
- MAPK15 p.Glu400Lys Uncertain significance Single submitter
- MAPK15 p.Glu428Gly Uncertain significance Single submitter
- MAPK15 p.Glu435Asp Uncertain significance Single submitter
- MAPK15 p.Gly107Ser Uncertain significance Single submitter
- MAPK15 p.Gly22Arg Uncertain significance Single submitter
- MAPK15 p.Gly22Trp Uncertain significance Single submitter
- MAPK15 p.Gly246Ser Uncertain significance Single submitter
- MAPK15 p.Gly351Ser Uncertain significance Single submitter
- MAPK15 p.Gly357Ala Uncertain significance Single submitter
- MAPK15 p.Gly360Ser Uncertain significance Single submitter
- MAPK15 p.Gly432Glu Uncertain significance Single submitter
- MAPK15 p.Gly471Val Uncertain significance Single submitter
- MAPK15 p.Gly477Ser Uncertain significance Single submitter
- MAPK15 p.Gly509Asp Uncertain significance Single submitter
- MAPK15 p.Gly513Cys Uncertain significance Single submitter
- MAPK15 p.Gly534Asp Uncertain significance Single submitter
- MAPK15 p.Gly541Glu Uncertain significance Single submitter
- MAPK15 p.His367Gln Uncertain significance Single submitter
- MAPK15 p.His369Gln Uncertain significance Single submitter
- MAPK15 p.Leu285Pro Uncertain significance Single submitter
- MAPK15 p.Leu419Pro Uncertain significance Single submitter
- MAPK15 p.Leu77Arg Uncertain significance Single submitter
- MAPK15 p.Leu99Pro Uncertain significance Single submitter
- MAPK15 p.Lys43Glu Uncertain significance Single submitter
- MAPK15 p.Met201Leu Uncertain significance Single submitter
- MAPK15 p.Met201Val Uncertain significance Single submitter
- MAPK15 p.Met95Ile Uncertain significance Single submitter
- MAPK15 p.Phe48Ile Uncertain significance Single submitter
- MAPK15 p.Phe48Ser Uncertain significance Single submitter
- MAPK15 p.Pro166Ala Uncertain significance Single submitter
- MAPK15 p.Pro235Leu Uncertain significance Single submitter
- MAPK15 p.Pro382Ala Uncertain significance Single submitter
- MAPK15 p.Pro411Ser Uncertain significance Single submitter
- MAPK15 p.Pro437Ser Uncertain significance Single submitter
- MAPK15 p.Pro453Ala Uncertain significance Single submitter
- MAPK15 p.Pro453Ser Uncertain significance Single submitter
- MAPK15 p.Pro493Leu Uncertain significance Single submitter
- MAPK15 p.Ser222Thr Uncertain significance Single submitter
- MAPK15 p.Ser353Leu Uncertain significance Single submitter
- MAPK15 p.Ser364Asn Uncertain significance Single submitter
- MAPK15 p.Ser442Pro Uncertain significance Single submitter
- MAPK15 p.Ser531Leu Uncertain significance Single submitter
- MAPK15 p.Thr273Ile Uncertain significance Single submitter
- MAPK15 p.Thr440Ser Uncertain significance Single submitter
- MAPK15 p.Thr504Ile Uncertain significance Single submitter
- MAPK15 p.Thr504Ser Uncertain significance Single submitter
- MAPK15 p.Tyr24His Uncertain significance Single submitter
- MAPK15 p.Val114Met Uncertain significance Single submitter
- MAPK15 p.Val134Met Uncertain significance Single submitter
- MAPK15 p.Val151Leu Uncertain significance Single submitter
- MAPK15 p.Val174Met Uncertain significance Single submitter
- MAPK15 p.Val39Met Uncertain significance Single submitter
- MAPK15 p.Val79Met Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- MAPK15 p.Ala295Thr Uncertain significance Single submitter
- MAPK15 p.Arg160His Uncertain significance Single submitter
- MAPK15 p.Arg213Pro Uncertain significance Single submitter
- MAPK15 p.Arg336Cys Uncertain significance Single submitter
- MAPK15 p.Arg338Cys Uncertain significance Single submitter
- MAPK15 p.Arg81Trp Uncertain significance Single submitter
- MAPK15 p.Gly214Ala Uncertain significance Single submitter
- MAPK15 p.Gly214Arg Uncertain significance Single submitter
- MAPK15 p.His193Tyr Uncertain significance Single submitter
- MAPK15 p.His225Tyr Uncertain significance Single submitter
- MAPK15 p.Leu162Gln Uncertain significance Single submitter
- MAPK15 p.Leu63Ile Uncertain significance Single submitter
- MAPK15 p.Val151Met Uncertain significance Single submitter
- MAPK15 p.Val178Met Uncertain significance Single submitter
- MAPK15 p.Val304Met Uncertain significance Single submitter
- MAPK15 p.Val332Gly Uncertain significance Single submitter
All MAPK15 variants
Benign 1
- p.Gly385Asp Single submitter
Likely benign 9
- p.Ser192Ter Multiple submitters
- p.Ala373Pro Single submitter
- p.Arg123Gln Single submitter
- p.Arg56= Single submitter
- p.Arg8His Single submitter
- p.Gly36Ser Single submitter
- p.Gly541Arg Single submitter
- p.Val112Ile Single submitter
- p.Val410Ile Single submitter
Uncertain significance 114
- p.Arg496Trp Multiple submitters ⚠
- p.Ala179Thr Single submitter ⚠
- p.Ala251Val Single submitter ⚠
- p.Ala295Thr Single submitter ⚠
- p.Ala40Val Single submitter ⚠
- p.Ala436Ser Single submitter ⚠
- p.Ala436Val Single submitter ⚠
- p.Ala514Thr Single submitter ⚠
- p.Arg104Gln Single submitter ⚠
- p.Arg115Pro Single submitter
- p.Arg136Gly Single submitter ⚠
- p.Arg136Pro Single submitter ⚠
- p.Arg160His Single submitter ⚠
- p.Arg213Gln Single submitter ⚠
- p.Arg213Leu Single submitter ⚠
- p.Arg213Pro Single submitter ⚠
- p.Arg250Cys Single submitter ⚠
- p.Arg262Gln Single submitter ⚠
- p.Arg262Leu Single submitter ⚠
- p.Arg262Pro Single submitter ⚠
- p.Arg283Gln Single submitter ⚠
- p.Arg292Pro Single submitter ⚠
- p.Arg292Trp Single submitter ⚠
- p.Arg316Gln Single submitter ⚠
- p.Arg323Trp Single submitter ⚠
- p.Arg336Cys Single submitter ⚠
- p.Arg338Cys Single submitter ⚠
- p.Arg33Pro Single submitter ⚠
- p.Arg380Lys Single submitter ⚠
- p.Arg470Gly Single submitter ⚠
- p.Arg475Gln Single submitter ⚠
- p.Arg490Trp Single submitter ⚠
- p.Arg499Gln Single submitter ⚠
- p.Arg81Trp Single submitter ⚠
- p.Asn84Thr Single submitter
- p.Asp200Tyr Single submitter ⚠
- p.Asp312Asn Single submitter ⚠
- p.Asp374Asn Single submitter ⚠
- p.Asp374Tyr Single submitter ⚠
- p.Gln120His Single submitter ⚠
- p.Gln120Lys Single submitter
- p.Gln391Arg Single submitter ⚠
- p.Gln523Leu Single submitter ⚠
- p.Glu187Lys Single submitter ⚠
- p.Glu400Lys Single submitter ⚠
- p.Glu428Gly Single submitter ⚠
- p.Glu435Asp Single submitter ⚠
- p.Gly107Ser Single submitter ⚠
- p.Gly214Ala Single submitter ⚠
- p.Gly214Arg Single submitter ⚠
- p.Gly220Ser Single submitter
- p.Gly22Arg Single submitter ⚠
- p.Gly22Trp Single submitter ⚠
- p.Gly246Ser Single submitter ⚠
- p.Gly351Ser Single submitter ⚠
- p.Gly357Ala Single submitter ⚠
- p.Gly360Ser Single submitter ⚠
- p.Gly432Glu Single submitter ⚠
- p.Gly471Val Single submitter ⚠
- p.Gly477Ser Single submitter ⚠
- p.Gly509Asp Single submitter ⚠
- p.Gly513Cys Single submitter ⚠
- p.Gly526Arg Single submitter
- p.Gly534Asp Single submitter ⚠
- p.Gly541Glu Single submitter ⚠
- p.His193Tyr Single submitter ⚠
- p.His225Tyr Single submitter ⚠
- p.His367Gln Single submitter ⚠
- p.His369Gln Single submitter ⚠
- p.Leu162Gln Single submitter ⚠
- p.Leu285Pro Single submitter ⚠
- p.Leu419Pro Single submitter ⚠
- p.Leu63Ile Single submitter ⚠
- p.Leu77Arg Single submitter ⚠
- p.Leu99Pro Single submitter ⚠
- p.Lys43Glu Single submitter ⚠
- p.Met201Leu Single submitter ⚠
- p.Met201Val Single submitter ⚠
- p.Met95Ile Single submitter ⚠
- p.Phe48Ile Single submitter ⚠
- p.Phe48Ser Single submitter ⚠
- p.Pro166Ala Single submitter ⚠
- p.Pro235Leu Single submitter ⚠
- p.Pro289Leu Single submitter
- p.Pro382Ala Single submitter ⚠
- p.Pro411Ser Single submitter ⚠
- p.Pro437Ser Single submitter ⚠
- p.Pro453Ala Single submitter ⚠
- p.Pro453Ser Single submitter ⚠
- p.Pro493Leu Single submitter ⚠
- p.Ser222Thr Single submitter ⚠
- p.Ser353Leu Single submitter ⚠
- p.Ser364Asn Single submitter ⚠
- p.Ser442Pro Single submitter ⚠
- p.Ser531Leu Single submitter ⚠
- p.Thr223Ile Single submitter
- p.Thr273Ile Single submitter ⚠
- p.Thr440Ser Single submitter ⚠
- p.Thr504Ile Single submitter ⚠
- p.Thr504Ser Single submitter ⚠
- p.Tyr24His Single submitter ⚠
- p.Val102Ala Single submitter
- p.Val114Met Single submitter ⚠
- p.Val134Met Single submitter ⚠
- p.Val151Leu Single submitter ⚠
- p.Val151Met Single submitter ⚠
- p.Val174Met Single submitter ⚠
- p.Val178Met Single submitter ⚠
- p.Val199fs Single submitter
- p.Val304Met Single submitter ⚠
- p.Val332Gly Single submitter ⚠
- p.Val39Met Single submitter ⚠
- p.Val79Leu Single submitter
- p.Val79Met Single submitter ⚠