Sugi Variant

Sugi Variant/MCTP2

MCTP2 — 227 ClinVar variants

All ClinVar germline MCTP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 157 flagged for review →

1 Conflicting · 18 Benign · 39 Likely benign · 169 Uncertain significance

Full MCTP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 157

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 126

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 30

The independent predictors disagree with each other — read with care.

All MCTP2 variants

Conflicting classifications of pathogenicity 1

Benign 18

Likely benign 39

Uncertain significance 169