MED1 — 168 ClinVar variants
All ClinVar germline MED1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 150 flagged for review →
9 Likely benign · 159 Uncertain significance
Full MED1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 150
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 118
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MED1 p.Ala1056Ser Uncertain significance Single submitter
- MED1 p.Ala1426Asp Uncertain significance Single submitter
- MED1 p.Ala25Val Uncertain significance Single submitter
- MED1 p.Ala899Thr Uncertain significance Single submitter
- MED1 p.Ala940Gly Uncertain significance Single submitter
- MED1 p.Arg1487Gln Uncertain significance Single submitter
- MED1 p.Arg249Gln Uncertain significance Single submitter
- MED1 p.Arg249Gly Uncertain significance Single submitter
- MED1 p.Arg449Gly Uncertain significance Single submitter
- MED1 p.Arg585Gln Uncertain significance Single submitter
- MED1 p.Arg808Gln Uncertain significance Single submitter
- MED1 p.Arg997Trp Uncertain significance Single submitter
- MED1 p.Asn1028Asp Uncertain significance Single submitter
- MED1 p.Asn1264Asp Uncertain significance Single submitter
- MED1 p.Asn131Thr Uncertain significance Single submitter
- MED1 p.Asn856His Uncertain significance Single submitter
- MED1 p.Asn924Lys Uncertain significance Single submitter
- MED1 p.Asp115Glu Uncertain significance Single submitter
- MED1 p.Asp1483Glu Uncertain significance Single submitter
- MED1 p.Asp861Gly Uncertain significance Single submitter
- MED1 p.Asp894Gly Uncertain significance Single submitter
- MED1 p.Asp914Asn Uncertain significance Single submitter
- MED1 p.Asp930Asn Uncertain significance Single submitter
- MED1 p.Cys324Gly Uncertain significance Single submitter
- MED1 p.Cys681Arg Uncertain significance Single submitter
- MED1 p.Gln1142His Uncertain significance Single submitter
- MED1 p.Gln119Glu Uncertain significance Single submitter
-
MED1 p.Gln371His
Uncertain significance
Single submitter
intellectual disability
- MED1 p.Glu347Lys Uncertain significance Single submitter
- MED1 p.Glu789Ala Uncertain significance Single submitter
- MED1 p.Glu9Gly Uncertain significance Single submitter
- MED1 p.Gly1139Ala Uncertain significance Single submitter
- MED1 p.Gly1150Trp Uncertain significance Single submitter
- MED1 p.Gly1230Ala Uncertain significance Single submitter
- MED1 p.Gly1446Cys Uncertain significance Single submitter
- MED1 p.Gly674Ser Uncertain significance Single submitter
- MED1 p.Gly938Ser Uncertain significance Single submitter
- MED1 p.Gly952Asp Uncertain significance Single submitter
- MED1 p.His1233Arg Uncertain significance Single submitter
- MED1 p.His1338Tyr Uncertain significance Single submitter
- MED1 p.His702Pro Uncertain significance Single submitter
- MED1 p.Ile1471Thr Uncertain significance Single submitter
- MED1 p.Ile1551Val Uncertain significance Single submitter
- MED1 p.Ile1566Thr Uncertain significance Single submitter
- MED1 p.Ile618Val Uncertain significance Single submitter
- MED1 p.Ile934Met Uncertain significance Single submitter
- MED1 p.Leu222Met Uncertain significance Single submitter
- MED1 p.Leu65Ser Uncertain significance Single submitter
- MED1 p.Leu74Ile Uncertain significance Single submitter
- MED1 p.Leu807Pro Uncertain significance Single submitter
- MED1 p.Leu906Phe Uncertain significance Single submitter
- MED1 p.Lys124Asn Uncertain significance Single submitter
- MED1 p.Lys1377Thr Uncertain significance Single submitter
- MED1 p.Lys1502Arg Uncertain significance Single submitter
- MED1 p.Lys152Glu Uncertain significance Single submitter
- MED1 p.Lys202Glu Uncertain significance Single submitter
- MED1 p.Lys235Gln Uncertain significance Single submitter
- MED1 p.Lys537Arg Uncertain significance Single submitter
- MED1 p.Lys896Arg Uncertain significance Single submitter
- MED1 p.Met1209Val Uncertain significance Single submitter
- MED1 p.Met1340Val Uncertain significance Single submitter
- MED1 p.Met253Val Uncertain significance Single submitter
- MED1 p.Met44Leu Uncertain significance Single submitter
- MED1 p.Met910Ile Uncertain significance Single submitter
- MED1 p.Met910Val Uncertain significance Single submitter
- MED1 p.Phe895Ile Uncertain significance Single submitter
- MED1 p.Pro213Ser Uncertain significance Single submitter
- MED1 p.Pro352Ala Uncertain significance Single submitter
- MED1 p.Pro435Ser Uncertain significance Single submitter
- MED1 p.Pro556Thr Uncertain significance Single submitter
- MED1 p.Pro568Leu Uncertain significance Single submitter
- MED1 p.Pro622Leu Uncertain significance Single submitter
- MED1 p.Pro696Leu Uncertain significance Single submitter
- MED1 p.Pro749Ala Uncertain significance Single submitter
- MED1 p.Pro75Ser Uncertain significance Single submitter
- MED1 p.Pro806Ser Uncertain significance Single submitter
- MED1 p.Pro849Ala Uncertain significance Single submitter
- MED1 p.Pro854Leu Uncertain significance Single submitter
- MED1 p.Pro854Ser Uncertain significance Single submitter
- MED1 p.Pro943Ala Uncertain significance Single submitter
- MED1 p.Ser1005Gly Uncertain significance Single submitter
- MED1 p.Ser1025Asn Uncertain significance Single submitter
- MED1 p.Ser1036Asn Uncertain significance Single submitter
- MED1 p.Ser1042Leu Uncertain significance Single submitter
- MED1 p.Ser1090Thr Uncertain significance Single submitter
- MED1 p.Ser1096Asn Uncertain significance Single submitter
- MED1 p.Ser1099Gly Uncertain significance Single submitter
- MED1 p.Ser1149Tyr Uncertain significance Single submitter
- MED1 p.Ser1155Phe Uncertain significance Single submitter
- MED1 p.Ser1164Asn Uncertain significance Single submitter
- MED1 p.Ser1194Phe Uncertain significance Single submitter
- MED1 p.Ser1219Phe Uncertain significance Single submitter
- MED1 p.Ser1240Asn Uncertain significance Single submitter
- MED1 p.Ser1254Leu Uncertain significance Single submitter
- MED1 p.Ser1374Tyr Uncertain significance Single submitter
- MED1 p.Ser1386Gly Uncertain significance Single submitter
- MED1 p.Ser151Phe Uncertain significance Single submitter
- MED1 p.Ser34Asn Uncertain significance Single submitter
- MED1 p.Ser853Phe Uncertain significance Single submitter
- MED1 p.Ser876Gly Uncertain significance Single submitter
- MED1 p.Ser889Asn Uncertain significance Single submitter
- MED1 p.Ser951Asn Uncertain significance Single submitter
- MED1 p.Ser984Leu Uncertain significance Single submitter
- MED1 p.Thr1267Met Uncertain significance Single submitter
- MED1 p.Thr1378Asn Uncertain significance Single submitter
- MED1 p.Thr1494Ile Uncertain significance Single submitter
- MED1 p.Thr292Ile Uncertain significance Single submitter
- MED1 p.Thr562Ala Uncertain significance Single submitter
- MED1 p.Thr617Ala Uncertain significance Single submitter
- MED1 p.Thr855Pro Uncertain significance Single submitter
- MED1 p.Thr960Ala Uncertain significance Single submitter
- MED1 p.Thr960Ser Uncertain significance Single submitter
- MED1 p.Tyr266Cys Uncertain significance Single submitter
- MED1 p.Val1384Ala Uncertain significance Single submitter
- MED1 p.Val1384Met Uncertain significance Single submitter
- MED1 p.Val1507Gly Uncertain significance Single submitter
- MED1 p.Val726Ile Uncertain significance Single submitter
-
MED1 p.Leu211Arg
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 32
The independent predictors disagree with each other — read with care.
- MED1 p.Arg1514Leu Uncertain significance Single submitter
- MED1 p.Arg1516Trp Uncertain significance Single submitter
- MED1 p.Arg41Cys Uncertain significance Single submitter
- MED1 p.Arg512Gln Uncertain significance Single submitter
- MED1 p.Arg513Lys Uncertain significance Single submitter
- MED1 p.Asn1190Lys Uncertain significance Single submitter
- MED1 p.Asn295Thr Uncertain significance Single submitter
- MED1 p.Asp1359Ala Uncertain significance Single submitter
- MED1 p.Asp1570Tyr Uncertain significance Single submitter
- MED1 p.Asp1572Gly Uncertain significance Single submitter
- MED1 p.Asp778Asn Uncertain significance Single submitter
- MED1 p.Asp884His Uncertain significance Single submitter
- MED1 p.Asp945His Uncertain significance Single submitter
- MED1 p.Glu260Gly Uncertain significance Single submitter
- MED1 p.Glu593Val Uncertain significance Single submitter
- MED1 p.Gly206Ala Uncertain significance Single submitter
- MED1 p.Gly570Arg Uncertain significance Single submitter
- MED1 p.His1497Leu Uncertain significance Single submitter
- MED1 p.Ile786Thr Uncertain significance Single submitter
- MED1 p.Leu388Pro Uncertain significance Single submitter
- MED1 p.Leu870Phe Uncertain significance Single submitter
- MED1 p.Lys1062Gln Uncertain significance Single submitter
- MED1 p.Met508Thr Uncertain significance Single submitter
- MED1 p.Phe567Leu Uncertain significance Single submitter
- MED1 p.Phe724Ile Uncertain significance Single submitter
- MED1 p.Pro1034Arg Uncertain significance Single submitter
- MED1 p.Pro1189Gln Uncertain significance Single submitter
- MED1 p.Ser1090Phe Uncertain significance Single submitter
- MED1 p.Ser1104Phe Uncertain significance Single submitter
- MED1 p.Ser1105Phe Uncertain significance Single submitter
- MED1 p.Ser616Cys Uncertain significance Single submitter
- MED1 p.Ser850Arg Uncertain significance Single submitter
All MED1 variants
Likely benign 9
- p.Gly955Ser Single submitter
- p.Ser1368= Single submitter
- p.Val265= Single submitter
- c.429-7C>T No assertion criteria intellectual disability
- p.Ala255Thr No assertion criteria intellectual disability
- p.Arg249Pro No assertion criteria MED1-related condition
- p.Pro213Leu No assertion criteria intellectual disability
- p.Ser1227Leu No assertion criteria intellectual disability
- p.Thr732Met No assertion criteria intellectual disability
Uncertain significance 159
- c.267-2A>G Single submitter
- p.Ala1056Ser Single submitter ⚠
- p.Ala1426Asp Single submitter ⚠
- p.Ala25Val Single submitter ⚠
- p.Ala899Thr Single submitter ⚠
- p.Ala940Gly Single submitter ⚠
- p.Arg1487Gln Single submitter ⚠
- p.Arg1514Leu Single submitter ⚠
- p.Arg1514Ter Single submitter
- p.Arg1516Trp Single submitter ⚠
- p.Arg249Gln Single submitter ⚠
- p.Arg249Gly Single submitter ⚠
- p.Arg41Cys Single submitter ⚠
- p.Arg449Gly Single submitter ⚠
- p.Arg512Gln Single submitter ⚠
- p.Arg513Lys Single submitter ⚠
- p.Arg585Gln Single submitter ⚠
- p.Arg585Trp Single submitter
- p.Arg768fs Single submitter
- p.Arg808Gln Single submitter ⚠
- p.Arg997Trp Single submitter ⚠
- p.Asn1028Asp Single submitter ⚠
- p.Asn1190Lys Single submitter ⚠
- p.Asn1264Asp Single submitter ⚠
- p.Asn131Thr Single submitter ⚠
- p.Asn295Thr Single submitter ⚠
- p.Asn856His Single submitter ⚠
- p.Asn924Lys Single submitter ⚠
- p.Asp115Glu Single submitter ⚠
- p.Asp1359Ala Single submitter ⚠
- p.Asp1483Glu Single submitter ⚠
- p.Asp1570Tyr Single submitter ⚠
- p.Asp1572Gly Single submitter ⚠
- p.Asp778Asn Single submitter ⚠
- p.Asp861Gly Single submitter ⚠
- p.Asp884His Single submitter ⚠
- p.Asp894Gly Single submitter ⚠
- p.Asp914Asn Single submitter ⚠
- p.Asp930Asn Single submitter ⚠
- p.Asp945His Single submitter ⚠
- p.Cys324Gly Single submitter ⚠
- p.Cys681Arg Single submitter ⚠
- p.Gln1142His Single submitter ⚠
- p.Gln119Glu Single submitter ⚠
- p.Gln371His Single submitter intellectual disability ⚠
- p.Glu260Gly Single submitter ⚠
- p.Glu347Lys Single submitter ⚠
- p.Glu593Val Single submitter ⚠
- p.Glu789Ala Single submitter ⚠
- p.Glu9Gly Single submitter ⚠
- p.Gly1139Ala Single submitter ⚠
- p.Gly1150Trp Single submitter ⚠
- p.Gly1230Ala Single submitter ⚠
- p.Gly1446Cys Single submitter ⚠
- p.Gly206Ala Single submitter ⚠
- p.Gly570Arg Single submitter ⚠
- p.Gly674Ser Single submitter ⚠
- p.Gly938Ser Single submitter ⚠
- p.Gly952Asp Single submitter ⚠
- p.His1233Arg Single submitter ⚠
- p.His1338Tyr Single submitter ⚠
- p.His1497Leu Single submitter ⚠
- p.His702Pro Single submitter ⚠
- p.Ile1471Thr Single submitter ⚠
- p.Ile1551Val Single submitter ⚠
- p.Ile1566Thr Single submitter ⚠
- p.Ile618Val Single submitter ⚠
- p.Ile786Thr Single submitter ⚠
- p.Ile934Met Single submitter ⚠
- p.Leu222Met Single submitter ⚠
- p.Leu388Pro Single submitter ⚠
- p.Leu65Ser Single submitter ⚠
- p.Leu660Pro Single submitter
- p.Leu74Ile Single submitter ⚠
- p.Leu807Pro Single submitter ⚠
- p.Leu870Phe Single submitter ⚠
- p.Leu906Phe Single submitter ⚠
- p.Lys1062Gln Single submitter ⚠
- p.Lys124Asn Single submitter ⚠
- p.Lys1377Thr Single submitter ⚠
- p.Lys1502Arg Single submitter ⚠
- p.Lys152Glu Single submitter ⚠
- p.Lys202Glu Single submitter ⚠
- p.Lys235Gln Single submitter ⚠
- p.Lys537Arg Single submitter ⚠
- p.Lys896Arg Single submitter ⚠
- p.Met1209Val Single submitter ⚠
- p.Met1340Val Single submitter ⚠
- p.Met253Val Single submitter ⚠
- p.Met44Leu Single submitter ⚠
- p.Met508Thr Single submitter ⚠
- p.Met910Ile Single submitter ⚠
- p.Met910Val Single submitter ⚠
- p.Phe567Leu Single submitter ⚠
- p.Phe724Ile Single submitter ⚠
- p.Phe895Ile Single submitter ⚠
- p.Pro1033Leu Single submitter
- p.Pro1034Arg Single submitter ⚠
- p.Pro1189Gln Single submitter ⚠
- p.Pro213Ser Single submitter ⚠
- p.Pro352Ala Single submitter ⚠
- p.Pro435Ser Single submitter ⚠
- p.Pro556Thr Single submitter ⚠
- p.Pro568Leu Single submitter ⚠
- p.Pro622Leu Single submitter ⚠
- p.Pro696Leu Single submitter ⚠
- p.Pro749Ala Single submitter ⚠
- p.Pro75Ser Single submitter ⚠
- p.Pro806Ser Single submitter ⚠
- p.Pro849Ala Single submitter ⚠
- p.Pro854Leu Single submitter ⚠
- p.Pro854Ser Single submitter ⚠
- p.Pro943Ala Single submitter ⚠
- p.Ser1005Gly Single submitter ⚠
- p.Ser1025Asn Single submitter ⚠
- p.Ser1036Asn Single submitter ⚠
- p.Ser1042Leu Single submitter ⚠
- p.Ser1090Phe Single submitter ⚠
- p.Ser1090Thr Single submitter ⚠
- p.Ser1096Asn Single submitter ⚠
- p.Ser1099Gly Single submitter ⚠
- p.Ser1104Phe Single submitter ⚠
- p.Ser1105Phe Single submitter ⚠
- p.Ser1149Tyr Single submitter ⚠
- p.Ser1155Phe Single submitter ⚠
- p.Ser1164Asn Single submitter ⚠
- p.Ser1194Phe Single submitter ⚠
- p.Ser1219Phe Single submitter ⚠
- p.Ser1240Asn Single submitter ⚠
- p.Ser1254Leu Single submitter ⚠
- p.Ser1342Phe Single submitter
- p.Ser1374Tyr Single submitter ⚠
- p.Ser1386Gly Single submitter ⚠
- p.Ser151Phe Single submitter ⚠
- p.Ser34Asn Single submitter ⚠
- p.Ser616Cys Single submitter ⚠
- p.Ser850Arg Single submitter ⚠
- p.Ser853Phe Single submitter ⚠
- p.Ser876Gly Single submitter ⚠
- p.Ser889Asn Single submitter ⚠
- p.Ser951Asn Single submitter ⚠
- p.Ser984Leu Single submitter ⚠
- p.Thr1267Met Single submitter ⚠
- p.Thr1378Asn Single submitter ⚠
- p.Thr1494Ile Single submitter ⚠
- p.Thr292Ile Single submitter ⚠
- p.Thr562Ala Single submitter ⚠
- p.Thr617Ala Single submitter ⚠
- p.Thr735Met Single submitter
- p.Thr855Pro Single submitter ⚠
- p.Thr960Ala Single submitter ⚠
- p.Thr960Ser Single submitter ⚠
- p.Tyr266Cys Single submitter ⚠
- p.Val1384Ala Single submitter ⚠
- p.Val1384Met Single submitter ⚠
- p.Val1507Gly Single submitter ⚠
- p.Val726Ile Single submitter ⚠
- p.Leu211Arg No assertion criteria prostate cancer ⚠
- p.Tyr102fs No assertion criteria MED1-related condition