METTL3 — 37 ClinVar variants
All ClinVar germline METTL3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 37 flagged for review →
37 Uncertain significance
Full METTL3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 37
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- METTL3 p.Ala191Val Uncertain significance Single submitter
- METTL3 p.Ala41Val Uncertain significance Single submitter
- METTL3 p.Ala73Pro Uncertain significance Single submitter
- METTL3 p.Arg179His Uncertain significance Single submitter
- METTL3 p.Arg292Gln Uncertain significance Single submitter
- METTL3 p.Arg36Gln Uncertain significance Single submitter
- METTL3 p.Arg47His Uncertain significance Single submitter
- METTL3 p.Asn230Ser Uncertain significance Single submitter
- METTL3 p.Asp114Asn Uncertain significance Single submitter
- METTL3 p.Asp138Glu Uncertain significance Single submitter
- METTL3 p.Asp183Val Uncertain significance Single submitter
- METTL3 p.Gln28Glu Uncertain significance Single submitter
- METTL3 p.Glu71Asp Uncertain significance Single submitter
- METTL3 p.Glu71Gln Uncertain significance Single submitter
- METTL3 p.Gly361Ala Uncertain significance Single submitter
- METTL3 p.Gly60Cys Uncertain significance Single submitter
- METTL3 p.His216Asn Uncertain significance Single submitter
- METTL3 p.His84Arg Uncertain significance Single submitter
- METTL3 p.Leu353Val Uncertain significance Single submitter
- METTL3 p.Leu72Ser Uncertain significance Single submitter
- METTL3 p.Lys296Arg Uncertain significance Single submitter
- METTL3 p.Pro209Ser Uncertain significance Single submitter
- METTL3 p.Pro61Ser Uncertain significance Single submitter
- METTL3 p.Ser184Leu Uncertain significance Single submitter
- METTL3 p.Thr143Ile Uncertain significance Single submitter
- METTL3 p.Thr146Ile Uncertain significance Single submitter
- METTL3 p.Thr186Ile Uncertain significance Single submitter
- METTL3 p.Thr252Ala Uncertain significance Single submitter
- METTL3 p.Thr348Met Uncertain significance Single submitter
- METTL3 p.Thr54Asn Uncertain significance Single submitter
- METTL3 p.Thr54Ser Uncertain significance Single submitter
- METTL3 p.Val383Ile Uncertain significance Single submitter
- METTL3 p.Val421Ile Uncertain significance Single submitter
- METTL3 p.Val562Ala Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All METTL3 variants
Uncertain significance 37
- p.Ala191Val Single submitter ⚠
- p.Ala41Val Single submitter ⚠
- p.Ala73Pro Single submitter ⚠
- p.Arg179His Single submitter ⚠
- p.Arg265Cys Single submitter ⚠
- p.Arg292Gln Single submitter ⚠
- p.Arg36Gln Single submitter ⚠
- p.Arg47His Single submitter ⚠
- p.Arg564Gln Single submitter ⚠
- p.Asn230Ser Single submitter ⚠
- p.Asp114Asn Single submitter ⚠
- p.Asp138Glu Single submitter ⚠
- p.Asp183Val Single submitter ⚠
- p.Gln28Glu Single submitter ⚠
- p.Glu71Asp Single submitter ⚠
- p.Glu71Gln Single submitter ⚠
- p.Gly361Ala Single submitter ⚠
- p.Gly60Cys Single submitter ⚠
- p.His216Asn Single submitter ⚠
- p.His84Arg Single submitter ⚠
- p.Leu353Val Single submitter ⚠
- p.Leu72Ser Single submitter ⚠
- p.Lys296Arg Single submitter ⚠
- p.Pro209Ser Single submitter ⚠
- p.Pro61Ser Single submitter ⚠
- p.Ser17Phe Single submitter ⚠
- p.Ser184Leu Single submitter ⚠
- p.Thr143Ile Single submitter ⚠
- p.Thr146Ile Single submitter ⚠
- p.Thr186Ile Single submitter ⚠
- p.Thr252Ala Single submitter ⚠
- p.Thr348Met Single submitter ⚠
- p.Thr54Asn Single submitter ⚠
- p.Thr54Ser Single submitter ⚠
- p.Val383Ile Single submitter ⚠
- p.Val421Ile Single submitter ⚠
- p.Val562Ala Single submitter ⚠