MGST1 — 25 ClinVar variants
All ClinVar germline MGST1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 19 flagged for review →
3 Likely benign · 22 Uncertain significance
Full MGST1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 19
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MGST1 p.Arg114Gln Uncertain significance Single submitter
- MGST1 p.Arg68Lys Uncertain significance Single submitter
- MGST1 p.Arg73Cys Uncertain significance Single submitter
- MGST1 p.Asp79Tyr Uncertain significance Single submitter
- MGST1 p.Gln6Arg Uncertain significance Single submitter
- MGST1 p.Gly137Arg Uncertain significance Single submitter
- MGST1 p.Gly97Cys Uncertain significance Single submitter
- MGST1 p.His106Arg Uncertain significance Single submitter
- MGST1 p.Leu63Val Uncertain significance Single submitter
- MGST1 p.Leu91Phe Uncertain significance Single submitter
- MGST1 p.Lys42Arg Uncertain significance Single submitter
- MGST1 p.Lys60Glu Uncertain significance Single submitter
- MGST1 p.Pro124Ser Uncertain significance Single submitter
- MGST1 p.Thr32Ser Uncertain significance Single submitter
- MGST1 p.Thr40Ala Uncertain significance Single submitter
- MGST1 p.Tyr138Cys Uncertain significance Single submitter
- MGST1 p.Val111Ala Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All MGST1 variants
Likely benign 3
- p.Ala35= Single submitter
- p.Pro100Leu Single submitter
- p.Val136Ile Single submitter
Uncertain significance 22
- p.Ala120Val Single submitter
- p.Arg114Gln Single submitter ⚠
- p.Arg41Ile Single submitter ⚠
- p.Arg68Lys Single submitter ⚠
- p.Arg73Cys Single submitter ⚠
- p.Arg73His Single submitter
- p.Asp79Tyr Single submitter ⚠
- p.Gln6Arg Single submitter ⚠
- p.Gly137Arg Single submitter ⚠
- p.Gly88Glu Single submitter ⚠
- p.Gly97Cys Single submitter ⚠
- p.His106Arg Single submitter ⚠
- p.Leu63Val Single submitter ⚠
- p.Leu91Phe Single submitter ⚠
- p.Lys42Arg Single submitter ⚠
- p.Lys60Glu Single submitter ⚠
- p.Met144Val Single submitter
- p.Pro124Ser Single submitter ⚠
- p.Thr32Ser Single submitter ⚠
- p.Thr40Ala Single submitter ⚠
- p.Tyr138Cys Single submitter ⚠
- p.Val111Ala Single submitter ⚠