MGST3 — 21 ClinVar variants
All ClinVar germline MGST3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 19 flagged for review →
2 Likely benign · 19 Uncertain significance
Full MGST3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 19
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MGST3 p.Ala92Pro Uncertain significance Single submitter
- MGST3 p.Arg84Cys Uncertain significance Single submitter
- MGST3 p.Arg84His Uncertain significance Single submitter
- MGST3 p.Arg97Gln Uncertain significance Single submitter
- MGST3 p.Asn28Ser Uncertain significance Single submitter
- MGST3 p.Gly96Ala Uncertain significance Single submitter
- MGST3 p.His82Tyr Uncertain significance Single submitter
- MGST3 p.Ile85Thr Uncertain significance Single submitter
- MGST3 p.Leu125Phe Uncertain significance Single submitter
- MGST3 p.Lys37Arg Uncertain significance Single submitter
- MGST3 p.Phe71Val Uncertain significance Single submitter
- MGST3 p.Pro70Ser Uncertain significance Single submitter
- MGST3 p.Tyr36Cys Uncertain significance Single submitter
- MGST3 p.Tyr81Cys Uncertain significance Single submitter
- MGST3 p.Tyr81Ser Uncertain significance Single submitter
- MGST3 p.Val95Ile Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All MGST3 variants
Likely benign 2
- p.Ile85Val Single submitter
- p.Val126Met Single submitter
Uncertain significance 19
- p.Ala92Pro Single submitter ⚠
- p.Arg84Cys Single submitter ⚠
- p.Arg84His Single submitter ⚠
- p.Arg97Gln Single submitter ⚠
- p.Asn28Ser Single submitter ⚠
- p.Gly138Asp Single submitter ⚠
- p.Gly96Ala Single submitter ⚠
- p.His82Tyr Single submitter ⚠
- p.Ile85Thr Single submitter ⚠
- p.Leu125Phe Single submitter ⚠
- p.Leu65Met Single submitter ⚠
- p.Leu72Phe Single submitter ⚠
- p.Lys37Arg Single submitter ⚠
- p.Phe71Val Single submitter ⚠
- p.Pro70Ser Single submitter ⚠
- p.Tyr36Cys Single submitter ⚠
- p.Tyr81Cys Single submitter ⚠
- p.Tyr81Ser Single submitter ⚠
- p.Val95Ile Single submitter ⚠