MKNK2 — 63 ClinVar variants
All ClinVar germline MKNK2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 57 flagged for review →
2 Likely benign · 61 Uncertain significance
Full MKNK2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 57
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 47
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MKNK2 p.Ala25Val Uncertain significance Single submitter
- MKNK2 p.Ala360Ser Uncertain significance Single submitter
- MKNK2 p.Ala372Thr Uncertain significance Single submitter
- MKNK2 p.Ala372Val Uncertain significance Single submitter
- MKNK2 p.Ala397Val Uncertain significance Single submitter
- MKNK2 p.Ala419Glu Uncertain significance Single submitter
- MKNK2 p.Ala419Val Uncertain significance Single submitter
- MKNK2 p.Ala44Thr Uncertain significance Single submitter
- MKNK2 p.Ala451Thr Uncertain significance Single submitter
- MKNK2 p.Ala465Thr Uncertain significance Single submitter
- MKNK2 p.Ala94Asp Uncertain significance Single submitter
- MKNK2 p.Arg123Trp Uncertain significance Single submitter
- MKNK2 p.Arg140Ser Uncertain significance Single submitter
- MKNK2 p.Arg447Leu Uncertain significance Single submitter
- MKNK2 p.Arg447Trp Uncertain significance Single submitter
- MKNK2 p.Arg45Cys Uncertain significance Single submitter
- MKNK2 p.Asn236His Uncertain significance Single submitter
- MKNK2 p.Asp29His Uncertain significance Single submitter
- MKNK2 p.Asp463Val Uncertain significance Single submitter
- MKNK2 p.Cys101Tyr Uncertain significance Single submitter
- MKNK2 p.Cys371Tyr Uncertain significance Single submitter
- MKNK2 p.Gln315Pro Uncertain significance Single submitter
- MKNK2 p.Glu129Lys Uncertain significance Single submitter
- MKNK2 p.Glu23Gln Uncertain significance Single submitter
- MKNK2 p.Glu417Lys Uncertain significance Single submitter
- MKNK2 p.Gly291Ala Uncertain significance Single submitter
- MKNK2 p.Gly34Arg Uncertain significance Single submitter
- MKNK2 p.Gly422Asp Uncertain significance Single submitter
- MKNK2 p.Gly63Val Uncertain significance Single submitter
- MKNK2 p.Leu168Pro Uncertain significance Single submitter
- MKNK2 p.Leu28Pro Uncertain significance Single submitter
- MKNK2 p.Leu9Ile Uncertain significance Single submitter
- MKNK2 p.Leu9Pro Uncertain significance Single submitter
- MKNK2 p.Lys354Gln Uncertain significance Single submitter
- MKNK2 p.Phe148Leu Uncertain significance Single submitter
- MKNK2 p.Phe26Cys Uncertain significance Single submitter
- MKNK2 p.Phe26Ser Uncertain significance Single submitter
- MKNK2 p.Phe26Val Uncertain significance Single submitter
- MKNK2 p.Pro330Ser Uncertain significance Single submitter
- MKNK2 p.Pro378Ala Uncertain significance Single submitter
- MKNK2 p.Pro57Leu Uncertain significance Single submitter
- MKNK2 p.Ser15Leu Uncertain significance Single submitter
- MKNK2 p.Ser280Asn Uncertain significance Single submitter
- MKNK2 p.Val142Ile Uncertain significance Single submitter
- MKNK2 p.Val382Ala Uncertain significance Single submitter
- MKNK2 p.Val425Ile Uncertain significance Single submitter
- MKNK2 p.Val458Leu Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- MKNK2 p.Arg14Pro Uncertain significance Single submitter
- MKNK2 p.Arg175Trp Uncertain significance Single submitter
- MKNK2 p.Arg68Cys Uncertain significance Single submitter
- MKNK2 p.His336Tyr Uncertain significance Single submitter
- MKNK2 p.Phe127Leu Uncertain significance Single submitter
- MKNK2 p.Phe16Leu Uncertain significance Single submitter
- MKNK2 p.Phe22Leu Uncertain significance Single submitter
- MKNK2 p.Pro241Ala Uncertain significance Single submitter
- MKNK2 p.Ser240Pro Uncertain significance Single submitter
- MKNK2 p.Thr72Ile Uncertain significance Single submitter
All MKNK2 variants
Likely benign 2
- p.Ala50Thr Single submitter
- p.Asn386= Single submitter
Uncertain significance 61
- p.Ala25Val Single submitter ⚠
- p.Ala360Ser Single submitter ⚠
- p.Ala372Thr Single submitter ⚠
- p.Ala372Val Single submitter ⚠
- p.Ala397Val Single submitter ⚠
- p.Ala419Glu Single submitter ⚠
- p.Ala419Val Single submitter ⚠
- p.Ala445Val Single submitter
- p.Ala44Thr Single submitter ⚠
- p.Ala451Thr Single submitter ⚠
- p.Ala465Thr Single submitter ⚠
- p.Ala94Asp Single submitter ⚠
- p.Arg123Trp Single submitter ⚠
- p.Arg140Ser Single submitter ⚠
- p.Arg14Pro Single submitter ⚠
- p.Arg175Trp Single submitter ⚠
- p.Arg351His Single submitter
- p.Arg447Leu Single submitter ⚠
- p.Arg447Trp Single submitter ⚠
- p.Arg45Cys Single submitter ⚠
- p.Arg68Cys Single submitter ⚠
- p.Asn236His Single submitter ⚠
- p.Asp29His Single submitter ⚠
- p.Asp463Val Single submitter ⚠
- p.Cys101Tyr Single submitter ⚠
- p.Cys371Tyr Single submitter ⚠
- p.Gln315Pro Single submitter ⚠
- p.Glu129Lys Single submitter ⚠
- p.Glu23Gln Single submitter ⚠
- p.Glu417Lys Single submitter ⚠
- p.Gly291Ala Single submitter ⚠
- p.Gly34Arg Single submitter ⚠
- p.Gly422Asp Single submitter ⚠
- p.Gly63Val Single submitter ⚠
- p.His172Asp Single submitter
- p.His336Tyr Single submitter ⚠
- p.Leu168Pro Single submitter ⚠
- p.Leu28Pro Single submitter ⚠
- p.Leu363Val Single submitter
- p.Leu9Ile Single submitter ⚠
- p.Leu9Pro Single submitter ⚠
- p.Lys354Gln Single submitter ⚠
- p.Phe127Leu Single submitter ⚠
- p.Phe148Leu Single submitter ⚠
- p.Phe16Leu Single submitter ⚠
- p.Phe22Leu Single submitter ⚠
- p.Phe26Cys Single submitter ⚠
- p.Phe26Ser Single submitter ⚠
- p.Phe26Val Single submitter ⚠
- p.Pro241Ala Single submitter ⚠
- p.Pro330Ser Single submitter ⚠
- p.Pro378Ala Single submitter ⚠
- p.Pro57Leu Single submitter ⚠
- p.Ser15Leu Single submitter ⚠
- p.Ser240Pro Single submitter ⚠
- p.Ser280Asn Single submitter ⚠
- p.Thr72Ile Single submitter ⚠
- p.Val142Ile Single submitter ⚠
- p.Val382Ala Single submitter ⚠
- p.Val425Ile Single submitter ⚠
- p.Val458Leu Single submitter ⚠