MLEC — 20 ClinVar variants
All ClinVar germline MLEC variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 16 flagged for review →
2 Benign · 18 Uncertain significance
Full MLEC gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 16
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 12
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MLEC p.Ala13Val Uncertain significance Single submitter
- MLEC p.Ala25Thr Uncertain significance Single submitter
- MLEC p.Ala25Val Uncertain significance Single submitter
- MLEC p.Ala39Val Uncertain significance Single submitter
- MLEC p.Arg259Cys Uncertain significance Single submitter
- MLEC p.Glu237Asp Uncertain significance Single submitter
- MLEC p.Gly32Arg Uncertain significance Single submitter
- MLEC p.Gly38Ser Uncertain significance Single submitter
- MLEC p.Lys190Gln Uncertain significance Single submitter
- MLEC p.Pro23Gln Uncertain significance Single submitter
- MLEC p.Pro284Ser Uncertain significance Single submitter
- MLEC p.Val148Ile Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All MLEC variants
Benign 2
- c.414+28C>T Multiple submitters
- c.236-2968C>T Single submitter
Uncertain significance 18
- p.Ala13Val Single submitter ⚠
- p.Ala25Thr Single submitter ⚠
- p.Ala25Val Single submitter ⚠
- p.Ala39Val Single submitter ⚠
- p.Arg259Cys Single submitter ⚠
- p.Asp217Gly Single submitter
- p.Glu107Gly Single submitter
- p.Glu236Lys Single submitter ⚠
- p.Glu237Asp Single submitter ⚠
- p.Gly32Arg Single submitter ⚠
- p.Gly38Ser Single submitter ⚠
- p.Lys190Gln Single submitter ⚠
- p.Met171Thr Single submitter ⚠
- p.Pro225Leu Single submitter ⚠
- p.Pro23Gln Single submitter ⚠
- p.Pro284Ser Single submitter ⚠
- p.Ser269Gly Single submitter ⚠
- p.Val148Ile Single submitter ⚠