Sugi Variant

Sugi Variant/MLH3

MLH3 — 3320 ClinVar variants

All ClinVar germline MLH3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 1954 flagged for review →

79 Pathogenic · 2 Pathogenic/Likely pathogenic · 10 Likely pathogenic · 165 Conflicting · 51 Benign · 208 Benign/Likely benign · 689 Likely benign · 2116 Uncertain significance

Full MLH3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 1954

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 88

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 1615

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 1615

Predictors split 251

The independent predictors disagree with each other — read with care. · showing the 150 best-reviewed of 251

All MLH3 variants

Pathogenic 79

Pathogenic/Likely pathogenic 2

  • p.Ala42fs Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Gly1319fs Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7

Likely pathogenic 10

  • p.Ile328fs Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • c.3571-1G>A Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ala577fs Single submitter
  • p.Gln24Ter Single submitter
  • p.Met1Thr Single submitter
  • p.Phe1150fs Single submitter
  • p.Ser287fs Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ser424fs Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Thr706fs Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Val934fs Single submitter endometrial carcinoma

Conflicting classifications of pathogenicity 165

  • c.3380-2A>G Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3465+14A>G Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3465+3G>A Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3571-1G>T Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3644-5T>C Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3716-1G>A Single submitter
  • c.3716-4A>G Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3827+1G>C Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3828-5T>C Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3988-1G>A Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.-3A>G Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.-4T>G Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.*2058G>T Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ala1076Thr Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ala1201= Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ala132Thr Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ala142Ser Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ala539Thr Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg1046Gln Single submitter colorectal cancer ⚠
  • p.Arg1098fs Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Arg1115Gln Single submitter endometrial carcinoma ⚠
  • p.Arg1333Ter Single submitter MLH3-related disorder
  • p.Arg1430His Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg1440Thr Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg210Ter Single submitter endometrial carcinoma
  • p.Arg257Lys Single submitter ovarian cancer ⚠
  • p.Arg297Trp Single submitter endometrial carcinoma ⚠
  • p.Arg381His Single submitter endometrial carcinoma ⚠
  • p.Arg546Ile Single submitter colorectal cancer ⚠
  • p.Arg600Gln Single submitter endometrial carcinoma ⚠
  • p.Arg600Ter Single submitter endometrial carcinoma
  • p.Arg647Cys Single submitter endometrial carcinoma ⚠
  • p.Arg647His Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg742Cys Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg742His Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg797Cys Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg895His Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg93Gly Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg93Ter Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asn1007Ser Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asn1038fs Single submitter MLH3-related disorder
  • p.Asn1147Ile Single submitter Hereditary cancer ⚠
  • p.Asn291Lys Single submitter endometrial carcinoma ⚠
  • p.Asn389Ser Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asn434fs Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asn436Asp Single submitter colorectal cancer ⚠
  • p.Asn540Tyr Single submitter colorectal cancer ⚠
  • p.Asn594Asp Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asn674fs Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asn674Lys Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asn897_Glu898delinsLysTer Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asn932fs Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asn932Ser Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asn975Asp Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asp1049Asn Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asp136fs Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asp206fs Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asp375= Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asp385His Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asp726Gly Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Cys590Ter Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Gln1123Ter Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Gln1245Ter Single submitter endometrial carcinoma
  • p.Gln1375Glu Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gln200Ter Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Gln341fs Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Gln513fs Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Gln698Arg Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gln760Ter Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Gln82Ter Single submitter colorectal cancer
  • p.Glu1035Lys Single submitter colorectal cancer ⚠
  • p.Glu1036_Ser1037insTer Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Glu1136Lys Single submitter ovarian cancer ⚠
  • p.Glu1213Lys Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Glu1451Lys Single submitter colorectal cancer ⚠
  • p.Glu28Ter Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Glu301Val Single submitter colorectal cancer ⚠
  • p.Glu559fs Single submitter colorectal cancer
  • p.Glu586fs Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Glu828Ter Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Glu848fs Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Gly1163Asp Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gly1184Glu Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gly1344= Single submitter endometrial carcinoma
  • p.Gly667Ala Single submitter colorectal cancer ⚠
  • p.Gly777Glu Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gly981Ser Single submitter Colorectal cancer, non-polyposis ⚠
  • p.His296fs Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ile1238Thr Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ile397del Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ile988Met Single submitter endometrial carcinoma ⚠
  • p.Ile995Thr Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Leu1052fs Single submitter MLH3-related disorder
  • p.Leu1192= Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu1259Ile Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Leu1259Val Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Leu1339Phe Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Leu252_Phe253insTer Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu497Ser Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Leu733Val Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Leu791= Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu856Phe Single submitter endometrial carcinoma ⚠
  • p.Lys113Arg Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Lys1183Arg Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Lys122Arg Single submitter endometrial carcinoma ⚠
  • p.Lys1413= Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Lys263Ter Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Lys412Glu Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Lys602Ter Single submitter MLH3-related disorder
  • p.Lys929Glu Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Lys949Thr Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Met1204Val Single submitter ovarian cancer ⚠
  • p.Met507Ile Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Met809Val Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Phe120Ser Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Phe390Ile Single submitter endometrial carcinoma ⚠
  • p.Phe50Tyr Single submitter Hereditary cancer ⚠
  • p.Phe627Leu Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Phe830Leu Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Phe832Leu Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Pro1008Leu Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Pro1262Ser Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Pro515fs Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Pro551Ser Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Pro715Ser Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Pro718Ser Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ser1134Gly Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ser1135= Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ser1188Ter Single submitter MLH3-related disorder
  • p.Ser1249Phe Single submitter colorectal cancer ⚠
  • p.Ser141= Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ser384= Single submitter endometrial carcinoma
  • p.Ser408Ter Single submitter colorectal cancer
  • p.Ser451Asn Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ser463Arg Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ser626Leu Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ser663fs Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ser711Pro Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ser727Asn Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ser812Asn Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ser812Thr Single submitter MLH3-related disorder ⚠
  • p.Ser940Phe Single submitter ovarian cancer ⚠
  • p.Ser946= Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Thr1128= Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Thr1420Ala Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Thr558Ala Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Thr661Ile Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Thr713fs Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Thr730Ile Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Thr968fs Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Thr980fs Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Trp1044Ter Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Trp528Arg Single submitter endometrial carcinoma ⚠
  • p.Trp719fs Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Tyr1241= Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Tyr1278= Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Tyr238Ser Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Tyr443Cys Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Tyr720Ter Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Tyr974Cys Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Val723Ile Single submitter colorectal cancer ⚠
  • p.Val741Ile Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Val786Ile Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Val934Ile Single submitter colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Val971Ile Single submitter endometrial carcinoma ⚠

Benign 51

Benign/Likely benign 208

  • c.3280+14A>T Multiple submitters colorectal cancer
  • c.3570+29AT[10] Multiple submitters
  • c.3644-13C>T Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • c.3827+11C>T Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • c.3987+15C>T Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • c.3987+7C>A Multiple submitters endometrial carcinoma
  • c.4011+15T>G Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • c.4091-22_4091-20del Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • c.4242+13C>G Multiple submitters endometrial carcinoma
  • c.4243-37_4243-1dup Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • c.-204G>A Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • c.*2965C>T Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • c.*3148A>G Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ala1114= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ala1169= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ala1358= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ala1365= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ala1428= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ala18= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ala243= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ala30= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ala42= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ala478= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ala557= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ala98= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Arg1098= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Arg174= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Arg44= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Arg797= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asn1314= Multiple submitters endometrial carcinoma
  • p.Asn1369= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asn248= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asn255= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asn283= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asn309= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asn369= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asn436= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asn776= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asn86= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asn956= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asn958= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asn975Ser Multiple submitters endometrial carcinoma
  • p.Asp1043= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asp1073Asn Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asp1105= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asp1105Glu Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asp136= Multiple submitters colorectal cancer
  • p.Asp1370= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asp1438= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asp206= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asp269= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asp334= Multiple submitters endometrial carcinoma
  • p.Asp385= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asp726= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asp802= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asp918= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Cys1378= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Cys279= Multiple submitters colorectal cancer
  • p.Cys339= Multiple submitters endometrial carcinoma
  • p.Cys920= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Gln1100= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Gln24= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Gln289= Multiple submitters endometrial carcinoma
  • p.Gln523= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Gln760= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Glu1242= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Glu169= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Glu275= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Glu316= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Glu455= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Glu580= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Glu624Gln Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Glu85= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Glu928= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Glu95= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Gly1163= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Gly1212= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Gly1216= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Gly143= Multiple submitters endometrial carcinoma
  • p.Gly607= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Gly777= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Gly91= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.His1225= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.His1395= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.His265= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.His494= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.His722= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.His811= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ile1200= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ile740= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ile935= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ile988= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu1082= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu1176= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu1203= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu123= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu1254= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu1255= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu13= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu130= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu1349= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu1351= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu1357= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu1380= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu1409= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu1419= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu166= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu178= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu180= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu189= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu201= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu252= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu258= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu271= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu272= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu751= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu798= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu853= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu858= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu880= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu972= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Lys1253= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Lys170= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Lys222= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Lys231Gln Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Lys3Arg Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Lys414= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Lys469= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Lys664= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Lys77= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Phe1067= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Phe1150= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Phe120= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Phe1391= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Phe596= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Phe642= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Pro1008= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Pro1112= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Pro1262= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Pro1292= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Pro1398= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Pro156= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Pro500= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Pro653= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Pro687= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Pro831= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Pro844Leu Multiple submitters hereditary neoplastic syndrome
  • p.Pro973= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ser1037= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ser110= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ser1104= Multiple submitters endometrial carcinoma
  • p.Ser1137= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ser1140= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ser1385= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ser15= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ser20= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ser287= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ser445= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ser464= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ser510= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ser531= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ser576= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ser587= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ser605= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ser649= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ser666= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ser80= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ser812= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ser816= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ser827= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ser845Gly Multiple submitters endometrial carcinoma
  • p.Ser849= Multiple submitters endometrial carcinoma
  • p.Ser902= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ser966Pro Multiple submitters endometrial carcinoma
  • p.Thr1039= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Thr1062= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Thr1066= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Thr1083= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Thr1084= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Thr1258= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Thr1342= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Thr286= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Thr326= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Thr532= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Thr579= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Thr661= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Thr677= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Thr692= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Thr75= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Thr780= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Thr889= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Thr942Ile Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Thr980= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Tyr245= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Tyr303= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Tyr598= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Tyr630= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Tyr681= Multiple submitters endometrial carcinoma
  • p.Tyr720Cys Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Val1222= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Val420Ile Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Val54= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Val741Phe Multiple submitters endometrial carcinoma
  • p.Val778= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Val786= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Val81= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Val9= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Val979= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7

Likely benign 689

Showing the top 300 by review status; the full set is in the sitemap.

  • c.3280+10T>C Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • c.3280+19T>C Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • c.3280+8C>T Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • c.3280+9G>A Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • c.3281-7T>C Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • c.3281-8A>G Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • c.3379+40C>T Multiple submitters
  • c.3465+4G>A Multiple submitters
  • c.3570+9T>C Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • c.3571-9G>C Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • c.3643+16A>G Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • c.3644-20C>T Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • c.3644-6A>G Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • c.3716-10C>T Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • c.3716-16A>C Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • c.3828-15A>C Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • c.3988-14C>G Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • c.4012-16C>T Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • c.4090+10del Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • c.4091-13G>C Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • c.4242+5A>G Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • c.4243-16T>C Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • c.*1896A>G Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ala1028= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ala1226= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ala177= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Arg1029= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Arg1317= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Arg1320= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Arg295= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Arg676= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Arg759= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asn32= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asn419= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asn629= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asn99= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asp1049= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asp1073= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asp427= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asp731= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asp769= Multiple submitters
  • p.Asp815= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Gln1360= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Gln639Lys Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Gln82= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Gln841= Multiple submitters
  • p.Glu1025= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Glu1166= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Glu1213= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Glu1229= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Glu134= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Glu232= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Glu493= Multiple submitters
  • p.Glu799= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Gly1003= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Gly1364= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Gly195= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Gly370= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Gly536= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Gly60= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Gly891= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Gly981= Multiple submitters
  • p.His1173= Multiple submitters
  • p.His182= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.His625= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu1005= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu1259= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu1275= Multiple submitters colorectal cancer
  • p.Leu1306= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu1431= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu1443= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu603= Multiple submitters
  • p.Leu710= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu922= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Leu987= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Lys486= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Lys552= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Lys703= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Lys805= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Lys854= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Lys868= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Lys881= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Lys926= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Met162Val Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Phe1102= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Pro1417= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Pro281= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Pro456= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Pro515= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Pro788Thr Multiple submitters endometrial carcinoma
  • p.Ser1023= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ser1134= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ser1442= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ser188= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ser468= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ser521= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ser660= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ser817Gly Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ser883= Multiple submitters
  • p.Thr1132= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Thr1322= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Thr1352= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Thr147= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Thr49= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Thr570= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Thr713= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Thr937= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Thr942= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Tyr73= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Val1133= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Val1290= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Val41= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Val612= Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • c.3280+14A>G Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3280+18A>C Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3280+18A>G Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3280+20G>A Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3280+48T>A Single submitter
  • c.3281-10T>C Single submitter
  • c.3281-35G>T Single submitter
  • c.3281-4T>C Single submitter
  • c.3281-8A>T Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3379+20C>G Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3380-10T>A Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3380-12C>T Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3380-14C>G Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3380-17G>A Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3465+14A>C Single submitter
  • c.3465+15G>A Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3465+36_3465+37dup Single submitter
  • c.3465+37dup Single submitter
  • c.3465+37T>C Single submitter
  • c.3465+38C>T Single submitter
  • c.3465+50C>A Single submitter
  • c.3465+9G>A Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3466-25A>G Single submitter
  • c.3466-27C>A Single submitter
  • c.3466-4C>T Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3466-5T>C Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3466-8C>T Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3570+27_3570+28insT Single submitter
  • c.3570+27_3570+28insTAT Single submitter
  • c.3570+27_3570+28insTATAT Single submitter
  • c.3570+27_3570+28insTATATAT Single submitter
  • c.3570+27_3570+28insTATATATAT Single submitter
  • c.3570+27_3570+28insTATATATATAT Single submitter
  • c.3570+29AT[7] Single submitter
  • c.3570+29AT[8] Single submitter
  • c.3570+30_3570+31insATTATAT Single submitter
  • c.3571-15T>C Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3571-16T>C Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3571-26G>T Single submitter
  • c.3571-9G>A Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3643+10G>A Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3643+19C>T Single submitter
  • c.3643+25G>A Single submitter
  • c.3643+33A>G Single submitter
  • c.3643+44T>C Single submitter
  • c.3643+6_3643+12del Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3643+8T>C Single submitter
  • c.3644-12T>A Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3644-16A>G Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3644-17A>C Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3644-25A>G Single submitter
  • c.3644-43G>A Single submitter
  • c.3644-7C>T Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3644-8T>C Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3715+10T>C Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3715+16C>T Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3715+18G>A Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3715+7A>T Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3715+8T>A Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3716-16A>G Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3716-19T>C Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3716-39C>T Single submitter
  • c.3827+13A>G Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3827+19A>T Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3827+39A>G Single submitter
  • c.3827+7A>G Single submitter
  • c.3827+9del Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3828-20A>G Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3828-24del Single submitter
  • c.3828-24dup Single submitter
  • c.3987+12C>A Single submitter
  • c.3987+45A>C Single submitter
  • c.3987+8A>G Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3988-19T>C Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3988-20A>T Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.3988-34G>A Single submitter
  • c.3988-9G>A Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.4011+10T>C Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.4011+12C>G Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.4011+17T>C Single submitter
  • c.4011+46A>G Single submitter
  • c.4012-15G>A Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.4012-15G>C Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.4012-18A>G Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.4090+18G>A Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.4090+39_4090+61del Single submitter
  • c.4090+7C>G Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.4091-13_4091-10del Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.4091-21T>A Single submitter
  • c.4091-39A>G Single submitter
  • c.4091-6A>T Single submitter
  • c.4242+14dup Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.4242+17C>T Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.4242+28G>C Single submitter
  • c.4242+40T>C Single submitter
  • c.4243-10C>A Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.4243-15T>G Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.4243-4A>G Single submitter
  • c.-133C>G Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.*1237A>G Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.*1347T>G Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.*1767G>A Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.*2174C>T Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.*2407T>C Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.*2590T>C Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.*3140C>T Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • c.*33del Single submitter
  • p.Ala1012= Single submitter
  • p.Ala1030Thr Single submitter
  • p.Ala106= Single submitter
  • p.Ala1069= Single submitter
  • p.Ala1086= Single submitter
  • p.Ala1227= Single submitter
  • p.Ala1246= Single submitter
  • p.Ala129= Single submitter
  • p.Ala132= Single submitter
  • p.Ala1394= Single submitter
  • p.Ala1404= Single submitter
  • p.Ala140Pro Single submitter
  • p.Ala1426= Single submitter
  • p.Ala36= Single submitter
  • p.Ala38= Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ala393= Single submitter
  • p.Ala438= Single submitter
  • p.Ala568= Single submitter
  • p.Ala577= Single submitter
  • p.Ala659= Single submitter
  • p.Ala696Thr Single submitter
  • p.Ala821= Single submitter
  • p.Ala874= Single submitter
  • p.Ala941= Single submitter
  • p.Ala990= Single submitter
  • p.Arg1046= Single submitter
  • p.Arg1113= Single submitter
  • p.Arg1118= Single submitter
  • p.Arg1126= Single submitter
  • p.Arg1230= Single submitter
  • p.Arg1232= Single submitter
  • p.Arg1251= Single submitter
  • p.Arg1333= Single submitter
  • p.Arg1430= Single submitter
  • p.Arg172= Single submitter
  • p.Arg273= Single submitter
  • p.Arg288= Single submitter
  • p.Arg297= Single submitter
  • p.Arg387= Single submitter
  • p.Arg387Lys Single submitter
  • p.Arg592= Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Arg592Gly Single submitter
  • p.Arg593= Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Arg600= Single submitter
  • p.Arg645= Single submitter
  • p.Arg676Lys Single submitter
  • p.Arg72= Single submitter
  • p.Arg728= Single submitter
  • p.Arg847= Single submitter
  • p.Arg879= Single submitter
  • p.Arg88= Single submitter
  • p.Arg885Lys Single submitter
  • p.Arg93= Single submitter
  • p.Asn1007= Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asn1017= Single submitter
  • p.Asn1038= Single submitter
  • p.Asn1059= Single submitter
  • p.Asn1093= Single submitter
  • p.Asn1125= Single submitter
  • p.Asn1211= Single submitter
  • p.Asn1418= Single submitter
  • p.Asn150= Single submitter
  • p.Asn191= Single submitter
  • p.Asn246= Single submitter
  • p.Asn389= Single submitter
  • p.Asn484= Single submitter
  • p.Asn57= Single submitter
  • p.Asn671= Single submitter
  • p.Asn674= Single submitter
  • p.Asn71Lys Single submitter
  • p.Asn725= Single submitter
  • p.Asn781Ser Single submitter
  • p.Asn826= Single submitter
  • p.Asn826Asp Single submitter colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asn860= Single submitter
  • p.Asn924= Single submitter
  • p.Asn924Lys Single submitter
  • p.Asn950= Single submitter
  • p.Asn958Ser Single submitter
  • p.Asp1011= Single submitter

Uncertain significance 2116

Showing the top 300 by review status; the full set is in the sitemap.

  • c.3280+4A>G Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • c.3379+4A>G Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • c.3643+2T>C Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • c.3643+4A>C Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • c.3643+5G>A Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • c.4090+2T>C Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • c.4091-2A>C Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ala1012Val Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ala1069Asp Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ala1069Val Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ala1116Gly Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ala1151Pro Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ala1151Ser Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ala11Thr Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ala1201Thr Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ala1214Thr Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ala1226Thr Multiple submitters colorectal cancer ⚠
  • p.Ala1227Val Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ala1394Thr Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ala1426Ser Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ala1426Val Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ala142Val Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ala177Thr Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ala243Gly Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ala243Val Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ala324Gly Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ala410Gly Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ala417Ser Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ala42Thr Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Ala438Glu Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ala438Val Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ala478Thr Multiple submitters endometrial carcinoma ⚠
  • p.Ala557Thr Multiple submitters MLH3-related disorder ⚠
  • p.Ala557Val Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ala568Thr Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ala96Thr Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg1046Trp Multiple submitters endometrial carcinoma ⚠
  • p.Arg1054Gly Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg1098Gly Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg1098Ser Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Arg1115Pro Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg1126Thr Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg1152Cys Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg1152His Multiple submitters colorectal cancer ⚠
  • p.Arg1180Gly Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg1180His Multiple submitters endometrial carcinoma ⚠
  • p.Arg1230Cys Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg1230His Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg1232Cys Multiple submitters colorectal cancer ⚠
  • p.Arg1232His Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg1251Gln Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg1251Trp Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg1317Gln Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg1317Trp Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg1320Ile Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg1333fs Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Arg1333Gln Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg1379Cys Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg1379His Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg1397Lys Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg139Gly Multiple submitters colorectal cancer ⚠
  • p.Arg1423Cys Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg1423His Multiple submitters colorectal cancer ⚠
  • p.Arg1430Cys Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg1430fs Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Arg14Cys Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg14His Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg159Lys Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg210Gln Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg288Ser Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg295Gln Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg297Gln Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg381Cys Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg381Leu Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg387Trp Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg413Ser Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg593Lys Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg593Ser Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg637Cys Multiple submitters ⚠
  • p.Arg637His Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg676Gly Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg721Gly Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg721Lys Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg72Gly Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Arg72His Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg742Gly Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg879Ile Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg895Cys Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg906Thr Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Arg93Gln Multiple submitters endometrial carcinoma ⚠
  • p.Asn1007Lys Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asn1125Ser Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asn1174del Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asn1174Thr Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asn1197His Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asn1217Ser Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asn1281Ser Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asn1314Ser Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asn1418Ser Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asn150Ser Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asn246del Multiple submitters endometrial carcinoma
  • p.Asn248Ser Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asn283Ser Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asn291Tyr Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asn395Asp Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asn434Asp Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asn436Ser Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asn460Lys Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asn540Ser Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asn57Ser Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asn589Ser Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asn594Ser Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asn629Thr Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asn725Lys Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asn725Ser Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asn776Ile Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asn860Tyr Multiple submitters ⚠
  • p.Asn901Asp Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asn901Ser Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asn925Lys Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asn948His Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asn950Lys Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asn962Lys Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asp1015Glu Multiple submitters endometrial carcinoma ⚠
  • p.Asp102Asn Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asp102Gly Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asp1043His Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asp1081Glu Multiple submitters endometrial carcinoma ⚠
  • p.Asp1081His Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asp1088Gly Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asp1105Asn Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asp1127Tyr Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asp1130Asn Multiple submitters endometrial carcinoma ⚠
  • p.Asp1130Gly Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asp1146Asn Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asp1159His Multiple submitters endometrial carcinoma ⚠
  • p.Asp1159Tyr Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asp1223Gly Multiple submitters ⚠
  • p.Asp1296Gly Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asp192Tyr Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asp206Gly Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asp269Gly Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asp318Val Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asp361Glu Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asp361Gly Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Asp361Val Multiple submitters colorectal cancer ⚠
  • p.Asp385Ala Multiple submitters endometrial carcinoma ⚠
  • p.Asp385Asn Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asp462Asn Multiple submitters MLH3-related disorder ⚠
  • p.Asp56Gly Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asp657Val Multiple submitters ⚠
  • p.Asp65His Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asp731Gly Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asp815Glu Multiple submitters ⚠
  • p.Asp815His Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asp815Val Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asp835Asn Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asp837Tyr Multiple submitters ⚠
  • p.Asp918Gly Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asp918Tyr Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asp983Tyr Multiple submitters ⚠
  • p.Asp985Ala Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asp985Asn Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Asp985Gly Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Cys1041Phe Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Cys133Gly Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Cys161Arg Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Cys208Arg Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Cys208Tyr Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Cys320Gly Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Cys339Arg Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Cys394Tyr Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Cys40Tyr Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Cys4Arg Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Cys590Trp Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Cys804Tyr Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Cys920Arg Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Cys963Gly Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gln1045Arg Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gln1096His Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gln1123Pro Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gln1190Lys Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gln1193Arg Multiple submitters endometrial carcinoma ⚠
  • p.Gln1244Pro Multiple submitters MLH3-related disorder ⚠
  • p.Gln1247Arg Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gln1247Leu Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gln1335His Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Gln1388Arg Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gln1388Leu Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gln1392Arg Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gln1392His Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gln1441Ter Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Gln1445fs Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Gln173His Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gln213Pro Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gln221Arg Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gln24Arg Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gln24Glu Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gln289His Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gln350Pro Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Gln459His Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gln523Lys Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gln563Arg Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gln639Arg Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gln785His Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Glu1010Gly Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Glu1234Lys Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Glu1242Lys Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Glu1264Asp Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Glu1264Lys Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Glu1288Ala Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Glu1312Ala Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Glu1312Gly Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Glu1330Lys Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7
  • p.Glu1334Gly Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Glu1376Gly Multiple submitters ⚠
  • p.Glu1412Gln Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Glu1451Gln Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Glu167Gly Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Glu234Asp Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Glu242Lys Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Glu275Asp Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Glu316Gln Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Glu322Gln Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Glu322Gly Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Glu356Ala Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Glu37Gly Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Glu386Lys Multiple submitters endometrial carcinoma ⚠
  • p.Glu418Gly Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Glu444Gln Multiple submitters endometrial carcinoma ⚠
  • p.Glu485Gln Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Glu48Lys Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Glu520Asp Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Glu580Gly Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Glu684Asp Multiple submitters endometrial carcinoma ⚠
  • p.Glu771Asp Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Glu799Gln Multiple submitters endometrial carcinoma ⚠
  • p.Glu828Gly Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Glu828Lys Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Glu855Asp Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Glu867Gly Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Glu884Lys Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Glu931Asp Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Glu95Lys Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gly1014Ser Multiple submitters ⚠
  • p.Gly1018Glu Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gly1018Val Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gly1094Arg Multiple submitters
  • p.Gly1184Arg Multiple submitters endometrial carcinoma ⚠
  • p.Gly1250Ser Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gly1250Val Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gly1286Asp Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gly1286Ser Multiple submitters ⚠
  • p.Gly1343Arg Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gly1347Arg Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gly1371Asp Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gly1396Arg Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gly1396Trp Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gly143Arg Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gly16Asp Multiple submitters ⚠
  • p.Gly370Ala Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gly370Arg Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gly370Cys Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gly536Ser Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gly634Ala Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gly643Glu Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gly700Cys Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gly752Arg Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gly752Glu Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gly882Asp Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gly882Cys Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gly933Asp Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gly94Glu Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Gly996Arg Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.His1363Arg Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.His1395Asp Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.His487Tyr Multiple submitters Astrocytoma IDH-mutant ⚠
  • p.His494Arg Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.His494Tyr Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.His517Tyr Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.His575Arg Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.His611Asn Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.His611Tyr Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.His648Arg Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.His722Arg Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.His722Tyr Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.His79Arg Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.His79Leu Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.His811Arg Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ile100Thr Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ile109Val Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ile1231Arg Multiple submitters MLH3-related disorder ⚠
  • p.Ile1238Val Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ile1265Val Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ile1327Thr Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ile1327Val Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ile1366Thr Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ile175Thr Multiple submitters ⚠
  • p.Ile185Val Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠
  • p.Ile226Lys Multiple submitters colorectal cancer, hereditary nonpolyposis, type 7 ⚠