MLXIP — 33 ClinVar variants
All ClinVar germline MLXIP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
33 Uncertain significance
Full MLXIP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MLXIP p.Ala203Val Uncertain significance Single submitter
- MLXIP p.Ala488Thr Uncertain significance Single submitter
- MLXIP p.Arg550Thr Uncertain significance Single submitter
- MLXIP p.Asn572Asp Uncertain significance Single submitter
- MLXIP p.Asn703Ser Uncertain significance Single submitter
- MLXIP p.Asp158Asn Uncertain significance Single submitter
- MLXIP p.Asp158Tyr Uncertain significance Single submitter
- MLXIP p.Gln533Lys Uncertain significance Single submitter
- MLXIP p.Gln770Leu Uncertain significance Single submitter
- MLXIP p.Gly476Arg Uncertain significance Single submitter
- MLXIP p.Gly522Arg Uncertain significance Single submitter
- MLXIP p.Gly635Ala Uncertain significance Single submitter
- MLXIP p.Gly668Ser Uncertain significance Single submitter
- MLXIP p.Gly66Ser Uncertain significance Single submitter
- MLXIP p.Gly676Trp Uncertain significance Single submitter
- MLXIP p.Gly685Glu Uncertain significance Single submitter
- MLXIP p.Lys209Arg Uncertain significance Single submitter
- MLXIP p.Pro439Ser Uncertain significance Single submitter
- MLXIP p.Pro520Ser Uncertain significance Single submitter
- MLXIP p.Pro527Ser Uncertain significance Single submitter
- MLXIP p.Pro620Ser Uncertain significance Single submitter
- MLXIP p.Pro670Leu Uncertain significance Single submitter
- MLXIP p.Ser646Phe Uncertain significance Single submitter
- MLXIP p.Ser651Asn Uncertain significance Single submitter
- MLXIP p.Ser744Asn Uncertain significance Single submitter
- MLXIP p.Thr673Ile Uncertain significance Single submitter
- MLXIP p.Tyr174Cys Uncertain significance Single submitter
- MLXIP p.Val528Ile Uncertain significance Single submitter
- MLXIP p.Val587Leu Uncertain significance Single submitter
- MLXIP p.Val587Met Uncertain significance Single submitter
Predictors split 1
The independent predictors disagree with each other — read with care.
All MLXIP variants
Uncertain significance 33
- c.2385-2A>G Single submitter
- p.Ala203Val Single submitter ⚠
- p.Ala488Thr Single submitter ⚠
- p.Arg550Thr Single submitter ⚠
- p.Asn572Asp Single submitter ⚠
- p.Asn703Ser Single submitter ⚠
- p.Asp158Asn Single submitter ⚠
- p.Asp158Tyr Single submitter ⚠
- p.Gln533Lys Single submitter ⚠
- p.Gln770Leu Single submitter ⚠
- p.Gly476Arg Single submitter ⚠
- p.Gly522Arg Single submitter ⚠
- p.Gly635Ala Single submitter ⚠
- p.Gly668Ser Single submitter ⚠
- p.Gly66Ser Single submitter ⚠
- p.Gly676Trp Single submitter ⚠
- p.Gly685Glu Single submitter ⚠
- p.Leu492= Single submitter
- p.Lys209Arg Single submitter ⚠
- p.Pro439Ser Single submitter ⚠
- p.Pro520Ser Single submitter ⚠
- p.Pro527Ser Single submitter ⚠
- p.Pro620Ser Single submitter ⚠
- p.Pro670Leu Single submitter ⚠
- p.Ser646Phe Single submitter ⚠
- p.Ser651Asn Single submitter ⚠
- p.Ser744Asn Single submitter ⚠
- p.Ser79Asn Single submitter ⚠
- p.Thr673Ile Single submitter ⚠
- p.Tyr174Cys Single submitter ⚠
- p.Val528Ile Single submitter ⚠
- p.Val587Leu Single submitter ⚠
- p.Val587Met Single submitter ⚠