MMP16 — 49 ClinVar variants
All ClinVar germline MMP16 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
3 Benign · 1 Likely benign · 45 Uncertain significance
Full MMP16 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 38
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MMP16 p.Arg117Gln Uncertain significance Single submitter
- MMP16 p.Arg310His Uncertain significance Single submitter
- MMP16 p.Arg327Gln Uncertain significance Single submitter
- MMP16 p.Arg354His Uncertain significance Single submitter
- MMP16 p.Arg355His Uncertain significance Single submitter
- MMP16 p.Arg538Gly Uncertain significance Single submitter
- MMP16 p.Asn275Lys Uncertain significance Single submitter
- MMP16 p.Asn280Asp Uncertain significance Single submitter
- MMP16 p.Asn409Ser Uncertain significance Single submitter
- MMP16 p.Gln77Pro Uncertain significance Single submitter
- MMP16 p.Glu495Val Uncertain significance Single submitter
- MMP16 p.Gly337Arg Uncertain significance Single submitter
- MMP16 p.Gly591Ala Uncertain significance Single submitter
- MMP16 p.His114Arg Uncertain significance Single submitter
- MMP16 p.His17Asn Uncertain significance Single submitter
- MMP16 p.His437Arg Uncertain significance Single submitter
- MMP16 p.His543Tyr Uncertain significance Single submitter
- MMP16 p.Ile296Ser Uncertain significance Single submitter
- MMP16 p.Leu26Trp Uncertain significance Single submitter
- MMP16 p.Leu430Phe Uncertain significance Single submitter
- MMP16 p.Leu73Val Uncertain significance Single submitter
- MMP16 p.Lys112Gln Uncertain significance Single submitter
- MMP16 p.Lys150Gln Uncertain significance Single submitter
- MMP16 p.Lys319Glu Uncertain significance Single submitter
- MMP16 p.Lys505Arg Uncertain significance Single submitter
- MMP16 p.Lys590Arg Uncertain significance Single submitter
- MMP16 p.Lys97Arg Uncertain significance Single submitter
- MMP16 p.Met357Leu Uncertain significance Single submitter
- MMP16 p.Pro297Ala Uncertain significance Single submitter
- MMP16 p.Pro474Leu Uncertain significance Single submitter
- MMP16 p.Pro99Leu Uncertain significance Single submitter
- MMP16 p.Ser391Asn Uncertain significance Single submitter
- MMP16 p.Ser399Gly Uncertain significance Single submitter
- MMP16 p.Thr107Ile Uncertain significance Single submitter
- MMP16 p.Thr418Ala Uncertain significance Single submitter
- MMP16 p.Thr536Ile Uncertain significance Single submitter
- MMP16 p.Thr561Pro Uncertain significance Single submitter
- MMP16 p.Val404Leu Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- MMP16 p.Arg369Lys Uncertain significance Single submitter
- MMP16 p.Arg386Trp Uncertain significance Single submitter
- MMP16 p.Gly401Arg Uncertain significance Single submitter
- MMP16 p.Gly433Ala Uncertain significance Single submitter
- MMP16 p.Tyr80Cys Uncertain significance Single submitter
- MMP16 p.Val517Ile Uncertain significance Single submitter
All MMP16 variants
Benign 3
- c.*2392G>A Multiple submitters
- p.Tyr377= Single submitter
- p.Val34= Single submitter
Likely benign 1
- c.282-6_282-4del Single submitter
Uncertain significance 45
- p.Arg117Gln Single submitter ⚠
- p.Arg310His Single submitter ⚠
- p.Arg327Gln Single submitter ⚠
- p.Arg354His Single submitter ⚠
- p.Arg355His Single submitter ⚠
- p.Arg367Ter Single submitter
- p.Arg369Lys Single submitter ⚠
- p.Arg386Trp Single submitter ⚠
- p.Arg538Gly Single submitter ⚠
- p.Asn275Lys Single submitter ⚠
- p.Asn280Asp Single submitter ⚠
- p.Asn409Ser Single submitter ⚠
- p.Gln77Pro Single submitter ⚠
- p.Glu495Val Single submitter ⚠
- p.Gly337Arg Single submitter ⚠
- p.Gly401Arg Single submitter ⚠
- p.Gly433Ala Single submitter ⚠
- p.Gly591Ala Single submitter ⚠
- p.His114Arg Single submitter ⚠
- p.His17Asn Single submitter ⚠
- p.His437Arg Single submitter ⚠
- p.His543Tyr Single submitter ⚠
- p.Ile296Ser Single submitter ⚠
- p.Leu26Trp Single submitter ⚠
- p.Leu430Phe Single submitter ⚠
- p.Leu73Val Single submitter ⚠
- p.Lys112Gln Single submitter ⚠
- p.Lys150Gln Single submitter ⚠
- p.Lys319Glu Single submitter ⚠
- p.Lys505Arg Single submitter ⚠
- p.Lys590Arg Single submitter ⚠
- p.Lys97Arg Single submitter ⚠
- p.Met357Leu Single submitter ⚠
- p.Pro297Ala Single submitter ⚠
- p.Pro474Leu Single submitter ⚠
- p.Pro99Leu Single submitter ⚠
- p.Ser391Asn Single submitter ⚠
- p.Ser399Gly Single submitter ⚠
- p.Thr107Ile Single submitter ⚠
- p.Thr418Ala Single submitter ⚠
- p.Thr536Ile Single submitter ⚠
- p.Thr561Pro Single submitter ⚠
- p.Tyr80Cys Single submitter ⚠
- p.Val404Leu Single submitter ⚠
- p.Val517Ile Single submitter ⚠