MPST — 52 ClinVar variants
All ClinVar germline MPST variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 45 flagged for review →
2 Likely benign · 50 Uncertain significance
Full MPST gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 45
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MPST p.Ala103Glu Uncertain significance Single submitter
- MPST p.Ala130Val Uncertain significance Single submitter
- MPST p.Ala33Val Uncertain significance Single submitter
- MPST p.Ala39Val Uncertain significance Single submitter
- MPST p.Ala45Ser Uncertain significance Single submitter
- MPST p.Ala77Val Uncertain significance Single submitter
- MPST p.Arg153Ser Uncertain significance Single submitter
- MPST p.Arg157His Uncertain significance Single submitter
- MPST p.Arg204Leu Uncertain significance Single submitter
- MPST p.Arg210His Uncertain significance Single submitter
- MPST p.Arg88Ser Uncertain significance Single submitter
- MPST p.Asp87His Uncertain significance Single submitter
- MPST p.Gln34His Uncertain significance Single submitter
- MPST p.Gln34Lys Uncertain significance Single submitter
- MPST p.Glu173Asp Uncertain significance Single submitter
- MPST p.Glu255Lys Uncertain significance Single submitter
- MPST p.Gly110Ala Uncertain significance Single submitter
- MPST p.Gly294Ser Uncertain significance Single submitter
- MPST p.Gly98Arg Uncertain significance Single submitter
- MPST p.His116Asp Uncertain significance Single submitter
- MPST p.His251Asn Uncertain significance Single submitter
- MPST p.Lys244Arg Uncertain significance Single submitter
- MPST p.Met301Leu Uncertain significance Single submitter
- MPST p.Pro180Ser Uncertain significance Single submitter
- MPST p.Pro24Leu Uncertain significance Single submitter
- MPST p.Pro287Ser Uncertain significance Single submitter
- MPST p.Thr212Ile Uncertain significance Single submitter
- MPST p.Val133Ile Uncertain significance Single submitter
- MPST p.Val229Leu Uncertain significance Single submitter
- MPST p.Val272Ile Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- MPST p.Arg196Trp Uncertain significance Single submitter
- MPST p.Arg302His Uncertain significance Single submitter
- MPST p.Arg72His Uncertain significance Single submitter
- MPST p.Gln50Pro Uncertain significance Single submitter
- MPST p.Glu306Lys Uncertain significance Single submitter
- MPST p.Glu70Gln Uncertain significance Single submitter
- MPST p.Glu70Lys Uncertain significance Single submitter
- MPST p.Gly207Ser Uncertain significance Single submitter
- MPST p.Gly285Ser Uncertain significance Single submitter
- MPST p.Leu61Pro Uncertain significance Single submitter
- MPST p.Phe140Leu Uncertain significance Single submitter
- MPST p.Pro226Thr Uncertain significance Single submitter
- MPST p.Ser164Tyr Uncertain significance Single submitter
- MPST p.Ser195Pro Uncertain significance Single submitter
- MPST p.Tyr292Phe Uncertain significance Single submitter
All MPST variants
Likely benign 2
- p.Asp307Glu Single submitter
- p.Gly76Val No assertion criteria MPST-related disorder
Uncertain significance 50
- p.Ala103Glu Single submitter ⚠
- p.Ala130Val Single submitter ⚠
- p.Ala19Ser Single submitter
- p.Ala303Val Single submitter
- p.Ala33Val Single submitter ⚠
- p.Ala39Val Single submitter ⚠
- p.Ala45Ser Single submitter ⚠
- p.Ala77Val Single submitter ⚠
- p.Arg153Ser Single submitter ⚠
- p.Arg157His Single submitter ⚠
- p.Arg196Trp Single submitter ⚠
- p.Arg204Leu Single submitter ⚠
- p.Arg210His Single submitter ⚠
- p.Arg302Cys Single submitter
- p.Arg302His Single submitter ⚠
- p.Arg72His Single submitter ⚠
- p.Arg88Ser Single submitter ⚠
- p.Asp87His Single submitter ⚠
- p.Asp93Val Single submitter
- p.Gln34His Single submitter ⚠
- p.Gln34Lys Single submitter ⚠
- p.Gln50Pro Single submitter ⚠
- p.Glu173Asp Single submitter ⚠
- p.Glu255Lys Single submitter ⚠
- p.Glu306Lys Single submitter ⚠
- p.Glu70Gln Single submitter ⚠
- p.Glu70Lys Single submitter ⚠
- p.Gly110Ala Single submitter ⚠
- p.Gly207Ser Single submitter ⚠
- p.Gly285Ser Single submitter ⚠
- p.Gly294Ser Single submitter ⚠
- p.Gly98Arg Single submitter ⚠
- p.His116Asp Single submitter ⚠
- p.His251Asn Single submitter ⚠
- p.Ile74Met Single submitter
- p.Leu61Pro Single submitter ⚠
- p.Lys244Arg Single submitter ⚠
- p.Met301Leu Single submitter ⚠
- p.Phe140Leu Single submitter ⚠
- p.Pro180Ser Single submitter ⚠
- p.Pro226Thr Single submitter ⚠
- p.Pro24Leu Single submitter ⚠
- p.Pro287Ser Single submitter ⚠
- p.Ser164Tyr Single submitter ⚠
- p.Ser195Pro Single submitter ⚠
- p.Thr212Ile Single submitter ⚠
- p.Tyr292Phe Single submitter ⚠
- p.Val133Ile Single submitter ⚠
- p.Val229Leu Single submitter ⚠
- p.Val272Ile Single submitter ⚠