MRPL11 — 22 ClinVar variants
All ClinVar germline MRPL11 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 21 flagged for review →
22 Uncertain significance
Full MRPL11 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 21
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MRPL11 p.Ala109Val Uncertain significance Single submitter
- MRPL11 p.Arg102Gln Uncertain significance Single submitter
- MRPL11 p.Arg102Pro Uncertain significance Single submitter
- MRPL11 p.Arg122His Uncertain significance Single submitter
- MRPL11 p.Arg122Ser Uncertain significance Single submitter
- MRPL11 p.Arg149His Uncertain significance Single submitter
- MRPL11 p.Arg154His Uncertain significance Single submitter
- MRPL11 p.Asp127Asn Uncertain significance Single submitter
- MRPL11 p.Glu52Asp Uncertain significance Single submitter
- MRPL11 p.Glu98Gln Uncertain significance Single submitter
- MRPL11 p.Gly27Ser Uncertain significance Single submitter
- MRPL11 p.Ile173Thr Uncertain significance Single submitter
- MRPL11 p.Leu111Val Uncertain significance Single submitter
- MRPL11 p.Leu91Arg Uncertain significance Single submitter
- MRPL11 p.Pro85Leu Uncertain significance Single submitter
- MRPL11 p.Ser143Phe Uncertain significance Single submitter
- MRPL11 p.Val155Met Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All MRPL11 variants
Uncertain significance 22
- p.Ala109Val Single submitter ⚠
- p.Arg102Gln Single submitter ⚠
- p.Arg102Pro Single submitter ⚠
- p.Arg102Trp Single submitter ⚠
- p.Arg122His Single submitter ⚠
- p.Arg122Ser Single submitter ⚠
- p.Arg149Cys Single submitter ⚠
- p.Arg149His Single submitter ⚠
- p.Arg154Cys Single submitter ⚠
- p.Arg154His Single submitter ⚠
- p.Asp127Asn Single submitter ⚠
- p.Glu52Asp Single submitter ⚠
- p.Glu98Gln Single submitter ⚠
- p.Gly27Ser Single submitter ⚠
- p.Gly96Ala Single submitter
- p.Ile173Thr Single submitter ⚠
- p.Leu111Val Single submitter ⚠
- p.Leu91Arg Single submitter ⚠
- p.Phe167Leu Single submitter ⚠
- p.Pro85Leu Single submitter ⚠
- p.Ser143Phe Single submitter ⚠
- p.Val155Met Single submitter ⚠