MRPL19 — 40 ClinVar variants
All ClinVar germline MRPL19 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
4 Likely benign · 36 Uncertain significance
Full MRPL19 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MRPL19 p.Ala288Val Uncertain significance Single submitter
- MRPL19 p.Arg118His Uncertain significance Single submitter
- MRPL19 p.Arg235His Uncertain significance Single submitter
- MRPL19 p.Arg271Lys Uncertain significance Single submitter
- MRPL19 p.Arg42Gly Uncertain significance Single submitter
- MRPL19 p.Asn237Asp Uncertain significance Single submitter
- MRPL19 p.Asn239Ser Uncertain significance Single submitter
- MRPL19 p.Asp274Glu Uncertain significance Single submitter
- MRPL19 p.Gln252Leu Uncertain significance Single submitter
- MRPL19 p.Glu180Lys Uncertain significance Single submitter
- MRPL19 p.Glu272Gln Uncertain significance Single submitter
- MRPL19 p.Glu50Gln Uncertain significance Single submitter
- MRPL19 p.Glu70Gln Uncertain significance Single submitter
- MRPL19 p.Gly157Ala Uncertain significance Single submitter
- MRPL19 p.Ile278Ser Uncertain significance Single submitter
- MRPL19 p.Leu106Phe Uncertain significance Single submitter
- MRPL19 p.Leu117Val Uncertain significance Single submitter
- MRPL19 p.Leu179Ser Uncertain significance Single submitter
- MRPL19 p.Lys205Gln Uncertain significance Single submitter
- MRPL19 p.Lys290Arg Uncertain significance Single submitter
- MRPL19 p.Lys65Arg Uncertain significance Single submitter
- MRPL19 p.Met254Thr Uncertain significance Single submitter
- MRPL19 p.Pro226Thr Uncertain significance Single submitter
- MRPL19 p.Pro58Leu Uncertain significance Single submitter
- MRPL19 p.Pro71Ser Uncertain significance Single submitter
- MRPL19 p.Ser289Leu Uncertain significance Single submitter
- MRPL19 p.Val113Ile Uncertain significance Single submitter
- MRPL19 p.Val119Ile Uncertain significance Single submitter
- MRPL19 p.Val41Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- MRPL19 p.Arg182Trp Uncertain significance Single submitter
- MRPL19 p.Arg232Cys Uncertain significance Single submitter
- MRPL19 p.Arg232His Uncertain significance Single submitter
- MRPL19 p.Pro124Thr Uncertain significance Single submitter
- MRPL19 p.Pro216Thr Uncertain significance Single submitter
- MRPL19 p.Trp260Cys Uncertain significance Single submitter
- MRPL19 p.Tyr112Cys Uncertain significance Single submitter
All MRPL19 variants
Likely benign 4
- c.658-9C>A Multiple submitters
- c.658-9C>T Single submitter
- p.Arg291Lys Single submitter
- p.Phe200= Single submitter
Uncertain significance 36
- p.Ala288Val Single submitter ⚠
- p.Arg118His Single submitter ⚠
- p.Arg182Trp Single submitter ⚠
- p.Arg232Cys Single submitter ⚠
- p.Arg232His Single submitter ⚠
- p.Arg235His Single submitter ⚠
- p.Arg271Lys Single submitter ⚠
- p.Arg42Gly Single submitter ⚠
- p.Asn237Asp Single submitter ⚠
- p.Asn239Ser Single submitter ⚠
- p.Asp274Glu Single submitter ⚠
- p.Gln252Leu Single submitter ⚠
- p.Glu180Lys Single submitter ⚠
- p.Glu272Gln Single submitter ⚠
- p.Glu50Gln Single submitter ⚠
- p.Glu70Gln Single submitter ⚠
- p.Gly157Ala Single submitter ⚠
- p.Ile278Ser Single submitter ⚠
- p.Leu106Phe Single submitter ⚠
- p.Leu117Val Single submitter ⚠
- p.Leu179Ser Single submitter ⚠
- p.Lys205Gln Single submitter ⚠
- p.Lys290Arg Single submitter ⚠
- p.Lys65Arg Single submitter ⚠
- p.Met254Thr Single submitter ⚠
- p.Pro124Thr Single submitter ⚠
- p.Pro216Thr Single submitter ⚠
- p.Pro226Thr Single submitter ⚠
- p.Pro58Leu Single submitter ⚠
- p.Pro71Ser Single submitter ⚠
- p.Ser289Leu Single submitter ⚠
- p.Trp260Cys Single submitter ⚠
- p.Tyr112Cys Single submitter ⚠
- p.Val113Ile Single submitter ⚠
- p.Val119Ile Single submitter ⚠
- p.Val41Ile Single submitter ⚠