MRPL37 — 51 ClinVar variants
All ClinVar germline MRPL37 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 43 flagged for review →
1 Likely benign · 50 Uncertain significance
Full MRPL37 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 43
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MRPL37 p.Ala321Asp Uncertain significance Single submitter
- MRPL37 p.Ala71Glu Uncertain significance Single submitter
- MRPL37 p.Arg162Cys Uncertain significance Single submitter
- MRPL37 p.Arg229Gln Uncertain significance Single submitter
- MRPL37 p.Arg303Cys Uncertain significance Single submitter
- MRPL37 p.Arg303His Uncertain significance Single submitter
- MRPL37 p.Arg310Trp Uncertain significance Single submitter
- MRPL37 p.Asn145His Uncertain significance Single submitter
- MRPL37 p.Asp264Asn Uncertain significance Single submitter
- MRPL37 p.Glu148Gly Uncertain significance Single submitter
- MRPL37 p.Glu281Asp Uncertain significance Single submitter
- MRPL37 p.Gly116Asp Uncertain significance Single submitter
- MRPL37 p.His353Tyr Uncertain significance Single submitter
- MRPL37 p.Ile129Thr Uncertain significance Single submitter
- MRPL37 p.Ile259Val Uncertain significance Single submitter
- MRPL37 p.Ile263Val Uncertain significance Single submitter
- MRPL37 p.Leu155Val Uncertain significance Single submitter
- MRPL37 p.Leu236Pro Uncertain significance Single submitter
- MRPL37 p.Lys189Ile Uncertain significance Single submitter
- MRPL37 p.Lys296Glu Uncertain significance Single submitter
- MRPL37 p.Phe107Ser Uncertain significance Single submitter
- MRPL37 p.Pro286Ser Uncertain significance Single submitter
- MRPL37 p.Pro288Ser Uncertain significance Single submitter
- MRPL37 p.Pro77Leu Uncertain significance Single submitter
- MRPL37 p.Ser260Thr Uncertain significance Single submitter
- MRPL37 p.Thr208Met Uncertain significance Single submitter
- MRPL37 p.Thr277Ile Uncertain significance Single submitter
- MRPL37 p.Tyr257Cys Uncertain significance Single submitter
- MRPL37 p.Tyr283Cys Uncertain significance Single submitter
- MRPL37 p.Tyr329His Uncertain significance Single submitter
- MRPL37 p.Tyr82Cys Uncertain significance Single submitter
- MRPL37 p.Val154Ile Uncertain significance Single submitter
- MRPL37 p.Val181Met Uncertain significance Single submitter
- MRPL37 p.Val345Ala Uncertain significance Single submitter
- MRPL37 p.Val376Met Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- MRPL37 p.Ala211Val Uncertain significance Single submitter
- MRPL37 p.Ala321Ser Uncertain significance Single submitter
- MRPL37 p.Arg326Trp Uncertain significance Single submitter
- MRPL37 p.His420Tyr Uncertain significance Single submitter
- MRPL37 p.Pro143Leu Uncertain significance Single submitter
- MRPL37 p.Pro92Arg Uncertain significance Single submitter
- MRPL37 p.Ser231Arg Uncertain significance Single submitter
- MRPL37 p.Val340Met Uncertain significance Single submitter
All MRPL37 variants
Likely benign 1
- p.Leu293Phe Single submitter
Uncertain significance 50
- p.Ala211Val Single submitter ⚠
- p.Ala321Asp Single submitter ⚠
- p.Ala321Ser Single submitter ⚠
- p.Ala71Glu Single submitter ⚠
- p.Arg162Cys Single submitter ⚠
- p.Arg229Gln Single submitter ⚠
- p.Arg303Cys Single submitter ⚠
- p.Arg303His Single submitter ⚠
- p.Arg310Trp Single submitter ⚠
- p.Arg326Trp Single submitter ⚠
- p.Asn145His Single submitter ⚠
- p.Asp264Asn Single submitter ⚠
- p.Glu148Gly Single submitter ⚠
- p.Glu281Asp Single submitter ⚠
- p.Gly116Asp Single submitter ⚠
- p.His353Tyr Single submitter ⚠
- p.His420Arg Single submitter
- p.His420Leu Single submitter
- p.His420Tyr Single submitter ⚠
- p.Ile129Thr Single submitter ⚠
- p.Ile259Val Single submitter ⚠
- p.Ile263Val Single submitter ⚠
- p.Leu114Pro Single submitter
- p.Leu155Val Single submitter ⚠
- p.Leu236Pro Single submitter ⚠
- p.Leu336Phe Single submitter
- p.Lys189Ile Single submitter ⚠
- p.Lys296Glu Single submitter ⚠
- p.Phe107Ser Single submitter ⚠
- p.Pro143Leu Single submitter ⚠
- p.Pro286Ser Single submitter ⚠
- p.Pro288Ser Single submitter ⚠
- p.Pro68Arg Single submitter
- p.Pro77Leu Single submitter ⚠
- p.Pro92Arg Single submitter ⚠
- p.Ser231Arg Single submitter ⚠
- p.Ser260Thr Single submitter ⚠
- p.Thr208Met Single submitter ⚠
- p.Thr277Ile Single submitter ⚠
- p.Tyr257Cys Single submitter ⚠
- p.Tyr283Cys Single submitter ⚠
- p.Tyr285His Single submitter
- p.Tyr329His Single submitter ⚠
- p.Tyr82Cys Single submitter ⚠
- p.Val154Ile Single submitter ⚠
- p.Val181Met Single submitter ⚠
- p.Val340Met Single submitter ⚠
- p.Val345Ala Single submitter ⚠
- p.Val345Met Single submitter
- p.Val376Met Single submitter ⚠