MRPL38 — 69 ClinVar variants
All ClinVar germline MRPL38 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 62 flagged for review →
4 Likely benign · 65 Uncertain significance
Full MRPL38 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 62
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 46
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MRPL38 p.Ala109Ser Uncertain significance Single submitter
- MRPL38 p.Ala123Thr Uncertain significance Single submitter
- MRPL38 p.Arg106Gln Uncertain significance Single submitter
- MRPL38 p.Arg106Trp Uncertain significance Single submitter
- MRPL38 p.Arg170Gln Uncertain significance Single submitter
- MRPL38 p.Arg261Gln Uncertain significance Single submitter
- MRPL38 p.Arg322Cys Uncertain significance Single submitter
- MRPL38 p.Arg322His Uncertain significance Single submitter
- MRPL38 p.Arg346Gln Uncertain significance Single submitter
- MRPL38 p.Arg356Cys Uncertain significance Single submitter
- MRPL38 p.Arg356His Uncertain significance Single submitter
- MRPL38 p.Arg360Gln Uncertain significance Single submitter
- MRPL38 p.Arg364His Uncertain significance Single submitter
- MRPL38 p.Arg368Gln Uncertain significance Single submitter
- MRPL38 p.Arg368Trp Uncertain significance Single submitter
- MRPL38 p.Arg52Trp Uncertain significance Single submitter
- MRPL38 p.Arg58Trp Uncertain significance Single submitter
- MRPL38 p.Arg99Gln Uncertain significance Single submitter
- MRPL38 p.Asn44Lys Uncertain significance Single submitter
- MRPL38 p.Asp160Tyr Uncertain significance Single submitter
- MRPL38 p.Asp39Asn Uncertain significance Single submitter
- MRPL38 p.Cys321Arg Uncertain significance Single submitter
- MRPL38 p.Gln102Lys Uncertain significance Single submitter
- MRPL38 p.Gln108His Uncertain significance Single submitter
- MRPL38 p.Glu112Lys Uncertain significance Single submitter
- MRPL38 p.Glu118Gln Uncertain significance Single submitter
- MRPL38 p.Glu120Gly Uncertain significance Single submitter
- MRPL38 p.Glu197Lys Uncertain significance Single submitter
- MRPL38 p.Glu227Lys Uncertain significance Single submitter
- MRPL38 p.His332Gln Uncertain significance Single submitter
- MRPL38 p.His351Tyr Uncertain significance Single submitter
- MRPL38 p.His373Tyr Uncertain significance Single submitter
- MRPL38 p.Ile110Val Uncertain significance Single submitter
- MRPL38 p.Ile88Thr Uncertain significance Single submitter
- MRPL38 p.Leu255Phe Uncertain significance Single submitter
- MRPL38 p.Lys148Gln Uncertain significance Single submitter
- MRPL38 p.Phe167Leu Uncertain significance Single submitter
- MRPL38 p.Phe273Leu Uncertain significance Single submitter
- MRPL38 p.Pro253Arg Uncertain significance Single submitter
- MRPL38 p.Pro253Ser Uncertain significance Single submitter
- MRPL38 p.Pro257His Uncertain significance Single submitter
- MRPL38 p.Pro278Leu Uncertain significance Single submitter
- MRPL38 p.Pro95Leu Uncertain significance Single submitter
- MRPL38 p.Thr196Ala Uncertain significance Single submitter
- MRPL38 p.Tyr254Cys Uncertain significance Single submitter
- MRPL38 p.Tyr377Cys Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- MRPL38 p.Arg124His Uncertain significance Single submitter
- MRPL38 p.Arg136Trp Uncertain significance Single submitter
- MRPL38 p.Arg244Trp Uncertain significance Single submitter
- MRPL38 p.Arg286Cys Uncertain significance Single submitter
- MRPL38 p.Arg338Trp Uncertain significance Single submitter
- MRPL38 p.Arg346Trp Uncertain significance Single submitter
- MRPL38 p.Asp280Glu Uncertain significance Single submitter
- MRPL38 p.Glu138Lys Uncertain significance Single submitter
- MRPL38 p.Glu247Gly Uncertain significance Single submitter
- MRPL38 p.Gly144Ser Uncertain significance Single submitter
- MRPL38 p.Gly242Asp Uncertain significance Single submitter
- MRPL38 p.Pro257Leu Uncertain significance Single submitter
- MRPL38 p.Thr215Met Uncertain significance Single submitter
- MRPL38 p.Thr310Pro Uncertain significance Single submitter
- MRPL38 p.Tyr206Cys Uncertain significance Single submitter
- MRPL38 p.Tyr51His Uncertain significance Single submitter
All MRPL38 variants
Likely benign 4
- p.Ala285Thr Single submitter
- p.Arg121Gln Single submitter
- p.Leu255= Single submitter
- p.Thr196= Single submitter
Uncertain significance 65
- p.Ala109Ser Single submitter ⚠
- p.Ala123Thr Single submitter ⚠
- p.Arg106Gln Single submitter ⚠
- p.Arg106Trp Single submitter ⚠
- p.Arg124His Single submitter ⚠
- p.Arg136Trp Single submitter ⚠
- p.Arg170Gln Single submitter ⚠
- p.Arg244Trp Single submitter ⚠
- p.Arg261Gln Single submitter ⚠
- p.Arg286Cys Single submitter ⚠
- p.Arg322Cys Single submitter ⚠
- p.Arg322His Single submitter ⚠
- p.Arg338Trp Single submitter ⚠
- p.Arg346Gln Single submitter ⚠
- p.Arg346Trp Single submitter ⚠
- p.Arg356Cys Single submitter ⚠
- p.Arg356His Single submitter ⚠
- p.Arg360Gln Single submitter ⚠
- p.Arg364His Single submitter ⚠
- p.Arg368Gln Single submitter ⚠
- p.Arg368Trp Single submitter ⚠
- p.Arg52Trp Single submitter ⚠
- p.Arg58Trp Single submitter ⚠
- p.Arg99Gln Single submitter ⚠
- p.Asn44Lys Single submitter ⚠
- p.Asp160Tyr Single submitter ⚠
- p.Asp280Glu Single submitter ⚠
- p.Asp39Asn Single submitter ⚠
- p.Cys321Arg Single submitter ⚠
- p.Gln102Lys Single submitter ⚠
- p.Gln108His Single submitter ⚠
- p.Gln308Pro Single submitter
- p.Glu112Lys Single submitter ⚠
- p.Glu118Gln Single submitter ⚠
- p.Glu120Gly Single submitter ⚠
- p.Glu138Lys Single submitter ⚠
- p.Glu197Lys Single submitter ⚠
- p.Glu227Lys Single submitter ⚠
- p.Glu247Gly Single submitter ⚠
- p.Gly144Ser Single submitter ⚠
- p.Gly242Asp Single submitter ⚠
- p.His332Asn Single submitter
- p.His332Gln Single submitter ⚠
- p.His351Tyr Single submitter ⚠
- p.His373Tyr Single submitter ⚠
- p.Ile110Val Single submitter ⚠
- p.Ile88Thr Single submitter ⚠
- p.Leu255Phe Single submitter ⚠
- p.Lys148Gln Single submitter ⚠
- p.Phe167Leu Single submitter ⚠
- p.Phe273Leu Single submitter ⚠
- p.Pro253Arg Single submitter ⚠
- p.Pro253Ser Single submitter ⚠
- p.Pro257His Single submitter ⚠
- p.Pro257Leu Single submitter ⚠
- p.Pro278Leu Single submitter ⚠
- p.Pro362Ser Single submitter
- p.Pro95Leu Single submitter ⚠
- p.Thr196Ala Single submitter ⚠
- p.Thr215Met Single submitter ⚠
- p.Thr310Pro Single submitter ⚠
- p.Tyr206Cys Single submitter ⚠
- p.Tyr254Cys Single submitter ⚠
- p.Tyr377Cys Single submitter ⚠
- p.Tyr51His Single submitter ⚠