MRPL9 — 42 ClinVar variants
All ClinVar germline MRPL9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
2 Benign · 4 Likely benign · 36 Uncertain significance
Full MRPL9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MRPL9 p.Ala129Thr Uncertain significance Single submitter
- MRPL9 p.Ala162Val Uncertain significance Single submitter
- MRPL9 p.Ala202Thr Uncertain significance Single submitter
- MRPL9 p.Arg171Cys Uncertain significance Single submitter
- MRPL9 p.Arg191Cys Uncertain significance Single submitter
- MRPL9 p.Arg215Gln Uncertain significance Single submitter
- MRPL9 p.Arg58Leu Uncertain significance Single submitter
- MRPL9 p.Arg89Trp Uncertain significance Single submitter
- MRPL9 p.Asn179Ser Uncertain significance Single submitter
- MRPL9 p.Glu187Asp Uncertain significance Single submitter
- MRPL9 p.Glu218Lys Uncertain significance Single submitter
- MRPL9 p.Lys181Gln Uncertain significance Single submitter
- MRPL9 p.Lys91Glu Uncertain significance Single submitter
- MRPL9 p.Met176Val Uncertain significance Single submitter
- MRPL9 p.Pro90His Uncertain significance Single submitter
- MRPL9 p.Val201Ile Uncertain significance Single submitter
- MRPL9 p.Val238Leu Uncertain significance Single submitter
- MRPL9 p.Val238Met Uncertain significance Single submitter
- MRPL9 p.Val83Leu Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- MRPL9 p.Ala132Ser Uncertain significance Single submitter
- MRPL9 p.Ala259Thr Uncertain significance Single submitter
- MRPL9 p.Arg215Trp Uncertain significance Single submitter
- MRPL9 p.Arg72Cys Uncertain significance Single submitter
- MRPL9 p.Arg75Trp Uncertain significance Single submitter
- MRPL9 p.Arg78Pro Uncertain significance Single submitter
- MRPL9 p.Gly150Arg Uncertain significance Single submitter
- MRPL9 p.Leu118Ser Uncertain significance Single submitter
- MRPL9 p.Lys61Met Uncertain significance Single submitter
- MRPL9 p.Lys87Asn Uncertain significance Single submitter
- MRPL9 p.Met176Thr Uncertain significance Single submitter
- MRPL9 p.Phe193Leu Uncertain significance Single submitter
- MRPL9 p.Phe240Leu Uncertain significance Single submitter
- MRPL9 p.Thr157Ile Uncertain significance Single submitter
- MRPL9 p.Tyr248Ser Uncertain significance Single submitter
- MRPL9 p.Val225Leu Uncertain significance Single submitter
- MRPL9 p.Val231Leu Uncertain significance Single submitter
All MRPL9 variants
Benign 2
- c.311-9A>G Single submitter
- c.589-27_589-26dup Single submitter
Likely benign 4
- c.589-10_589-5dup Single submitter
- c.589-17_589-5dup Single submitter
- p.Pro265Ser Single submitter
- p.Val199= Single submitter
Uncertain significance 36
- p.Ala129Thr Single submitter ⚠
- p.Ala132Ser Single submitter ⚠
- p.Ala162Val Single submitter ⚠
- p.Ala202Thr Single submitter ⚠
- p.Ala259Thr Single submitter ⚠
- p.Arg171Cys Single submitter ⚠
- p.Arg191Cys Single submitter ⚠
- p.Arg215Gln Single submitter ⚠
- p.Arg215Trp Single submitter ⚠
- p.Arg58Leu Single submitter ⚠
- p.Arg72Cys Single submitter ⚠
- p.Arg75Trp Single submitter ⚠
- p.Arg78Pro Single submitter ⚠
- p.Arg89Trp Single submitter ⚠
- p.Asn179Ser Single submitter ⚠
- p.Glu187Asp Single submitter ⚠
- p.Glu218Lys Single submitter ⚠
- p.Gly150Arg Single submitter ⚠
- p.Leu118Ser Single submitter ⚠
- p.Lys181Gln Single submitter ⚠
- p.Lys61Met Single submitter ⚠
- p.Lys87Asn Single submitter ⚠
- p.Lys91Glu Single submitter ⚠
- p.Met176Thr Single submitter ⚠
- p.Met176Val Single submitter ⚠
- p.Phe193Leu Single submitter ⚠
- p.Phe240Leu Single submitter ⚠
- p.Pro90His Single submitter ⚠
- p.Thr157Ile Single submitter ⚠
- p.Tyr248Ser Single submitter ⚠
- p.Val201Ile Single submitter ⚠
- p.Val225Leu Single submitter ⚠
- p.Val231Leu Single submitter ⚠
- p.Val238Leu Single submitter ⚠
- p.Val238Met Single submitter ⚠
- p.Val83Leu Single submitter ⚠