MRPS35 — 44 ClinVar variants
All ClinVar germline MRPS35 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →
2 Benign · 8 Likely benign · 34 Uncertain significance
Full MRPS35 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 32
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 20
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MRPS35 p.Ala136Val Uncertain significance Single submitter
- MRPS35 p.Ala168Pro Uncertain significance Single submitter
- MRPS35 p.Ala222Ser Uncertain significance Single submitter
- MRPS35 p.Ala61Asp Uncertain significance Single submitter
- MRPS35 p.Asn110Ile Uncertain significance Single submitter
- MRPS35 p.Asn279Lys Uncertain significance Single submitter
- MRPS35 p.Asp184Ala Uncertain significance Single submitter
- MRPS35 p.Glu302Gly Uncertain significance Single submitter
- MRPS35 p.Leu105Arg Uncertain significance Single submitter
- MRPS35 p.Lys280Glu Uncertain significance Single submitter
- MRPS35 p.Met97Val Uncertain significance Single submitter
- MRPS35 p.Pro116Arg Uncertain significance Single submitter
- MRPS35 p.Pro42Leu Uncertain significance Single submitter
- MRPS35 p.Pro55Ala Uncertain significance Single submitter
- MRPS35 p.Ser179Gly Uncertain significance Single submitter
- MRPS35 p.Thr227Lys Uncertain significance Single submitter
- MRPS35 p.Trp234Ser Uncertain significance Single submitter
- MRPS35 p.Val296Ile Uncertain significance Single submitter
- MRPS35 p.Val297Phe Uncertain significance Single submitter
- MRPS35 p.Val95Met Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- MRPS35 p.Arg164Gln Uncertain significance Single submitter
- MRPS35 p.Arg164Trp Uncertain significance Single submitter
- MRPS35 p.Arg197Gln Uncertain significance Single submitter
- MRPS35 p.Asn110Ser Uncertain significance Single submitter
- MRPS35 p.Cys123Ser Uncertain significance Single submitter
- MRPS35 p.Glu254Gln Uncertain significance Single submitter
- MRPS35 p.His146Arg Uncertain significance Single submitter
- MRPS35 p.Lys77Glu Uncertain significance Single submitter
- MRPS35 p.Pro54Ser Uncertain significance Single submitter
- MRPS35 p.Ser139Gly Uncertain significance Single submitter
- MRPS35 p.Ser162Cys Uncertain significance Single submitter
- MRPS35 p.Ser315Phe Uncertain significance Single submitter
All MRPS35 variants
Benign 2
- p.Gly43Arg Multiple submitters
- p.Leu319= Multiple submitters
Likely benign 8
- p.Arg215= Single submitter
- p.Arg40Gly Single submitter
- p.Asn44Ser Single submitter
- p.Ile252Val Single submitter
- p.Leu225= Single submitter
- p.Pro55= Single submitter
- p.Tyr221= Single submitter
- p.Val223= Single submitter
Uncertain significance 34
- p.Ala136Val Single submitter ⚠
- p.Ala168Pro Single submitter ⚠
- p.Ala222Ser Single submitter ⚠
- p.Ala61Asp Single submitter ⚠
- p.Arg164Gln Single submitter ⚠
- p.Arg164Trp Single submitter ⚠
- p.Arg197Gln Single submitter ⚠
- p.Asn110Ile Single submitter ⚠
- p.Asn110Ser Single submitter ⚠
- p.Asn279Lys Single submitter ⚠
- p.Asp184Ala Single submitter ⚠
- p.Asp220Asn Single submitter
- p.Cys123Ser Single submitter ⚠
- p.Glu254Gln Single submitter ⚠
- p.Glu302Gly Single submitter ⚠
- p.His146Arg Single submitter ⚠
- p.Leu105Arg Single submitter ⚠
- p.Lys280Glu Single submitter ⚠
- p.Lys77Glu Single submitter ⚠
- p.Met97Val Single submitter ⚠
- p.Pro116Arg Single submitter ⚠
- p.Pro42Leu Single submitter ⚠
- p.Pro54Ser Single submitter ⚠
- p.Pro55Ala Single submitter ⚠
- p.Pro84Thr Single submitter
- p.Ser139Gly Single submitter ⚠
- p.Ser162Cys Single submitter ⚠
- p.Ser179Gly Single submitter ⚠
- p.Ser315Phe Single submitter ⚠
- p.Thr227Lys Single submitter ⚠
- p.Trp234Ser Single submitter ⚠
- p.Val296Ile Single submitter ⚠
- p.Val297Phe Single submitter ⚠
- p.Val95Met Single submitter ⚠