MRPS9 — 55 ClinVar variants
All ClinVar germline MRPS9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 50 flagged for review →
4 Likely benign · 51 Uncertain significance
Full MRPS9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 50
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 39
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MRPS9 p.Ala11Val Uncertain significance Single submitter
- MRPS9 p.Ala236Ser Uncertain significance Single submitter
- MRPS9 p.Ala281Val Uncertain significance Single submitter
- MRPS9 p.Ala339Thr Uncertain significance Single submitter
- MRPS9 p.Arg145Pro Uncertain significance Single submitter
- MRPS9 p.Arg243Ser Uncertain significance Single submitter
- MRPS9 p.Arg276Gly Uncertain significance Single submitter
- MRPS9 p.Arg375Cys Uncertain significance Single submitter
- MRPS9 p.Asn82Ser Uncertain significance Single submitter
- MRPS9 p.Asp164Ala Uncertain significance Single submitter
- MRPS9 p.Asp299Asn Uncertain significance Single submitter
- MRPS9 p.Asp309Gly Uncertain significance Single submitter
- MRPS9 p.Gln28Glu Uncertain significance Single submitter
- MRPS9 p.Gln39Pro Uncertain significance Single submitter
- MRPS9 p.Glu204Val Uncertain significance Single submitter
- MRPS9 p.Glu226Lys Uncertain significance Single submitter
- MRPS9 p.Glu358Lys Uncertain significance Single submitter
- MRPS9 p.Glu67Asp Uncertain significance Single submitter
- MRPS9 p.Gly234Asp Uncertain significance Single submitter
- MRPS9 p.Gly9Ser Uncertain significance Single submitter
- MRPS9 p.His288Arg Uncertain significance Single submitter
- MRPS9 p.Ile222Val Uncertain significance Single submitter
- MRPS9 p.Ile83Thr Uncertain significance Single submitter
- MRPS9 p.Leu185Phe Uncertain significance Single submitter
- MRPS9 p.Lys202Glu Uncertain significance Single submitter
- MRPS9 p.Lys253Ile Uncertain significance Single submitter
- MRPS9 p.Pro128Ala Uncertain significance Single submitter
- MRPS9 p.Ser333Leu Uncertain significance Single submitter
- MRPS9 p.Thr191Ser Uncertain significance Single submitter
- MRPS9 p.Thr230Ser Uncertain significance Single submitter
- MRPS9 p.Thr307Arg Uncertain significance Single submitter
- MRPS9 p.Trp140Cys Uncertain significance Single submitter
- MRPS9 p.Trp363Arg Uncertain significance Single submitter
- MRPS9 p.Trp363Leu Uncertain significance Single submitter
- MRPS9 p.Tyr152Cys Uncertain significance Single submitter
- MRPS9 p.Tyr262His Uncertain significance Single submitter
- MRPS9 p.Val194Met Uncertain significance Single submitter
- MRPS9 p.Val241Leu Uncertain significance Single submitter
- MRPS9 p.Val6Met Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- MRPS9 p.Arg245Gln Likely benign Single submitter
- MRPS9 p.Asn90Ser Uncertain significance Single submitter
- MRPS9 p.Asp164Val Uncertain significance Single submitter
- MRPS9 p.Glu360Lys Uncertain significance Single submitter
- MRPS9 p.Gly144Ser Uncertain significance Single submitter
- MRPS9 p.Met162Ile Uncertain significance Single submitter
- MRPS9 p.Tyr149Asp Uncertain significance Single submitter
- MRPS9 p.Tyr149Cys Uncertain significance Single submitter
- MRPS9 p.Val210Gly Uncertain significance Single submitter
- MRPS9 p.Val328Met Uncertain significance Single submitter
- MRPS9 p.Val6Glu Uncertain significance Single submitter
All MRPS9 variants
Likely benign 4
- p.Arg245Gln Single submitter ⚠
- p.Glu237= Single submitter
- p.His175Arg Single submitter
- p.Ser231= Single submitter
Uncertain significance 51
- p.Ala11Val Single submitter ⚠
- p.Ala236Ser Single submitter ⚠
- p.Ala281Val Single submitter ⚠
- p.Ala339Thr Single submitter ⚠
- p.Arg145Pro Single submitter ⚠
- p.Arg243Ser Single submitter ⚠
- p.Arg276Gly Single submitter ⚠
- p.Arg375Cys Single submitter ⚠
- p.Asn82Ser Single submitter ⚠
- p.Asn90Ser Single submitter ⚠
- p.Asp164Ala Single submitter ⚠
- p.Asp164Val Single submitter ⚠
- p.Asp299Asn Single submitter ⚠
- p.Asp309Gly Single submitter ⚠
- p.Gln28Glu Single submitter ⚠
- p.Gln39Pro Single submitter ⚠
- p.Glu204Val Single submitter ⚠
- p.Glu226Lys Single submitter ⚠
- p.Glu358Lys Single submitter ⚠
- p.Glu360Lys Single submitter ⚠
- p.Glu362Lys Single submitter
- p.Glu67Asp Single submitter ⚠
- p.Gly144Ser Single submitter ⚠
- p.Gly234Asp Single submitter ⚠
- p.Gly9Ser Single submitter ⚠
- p.His288Arg Single submitter ⚠
- p.Ile222Val Single submitter ⚠
- p.Ile83Thr Single submitter ⚠
- p.Leu185Phe Single submitter ⚠
- p.Lys202Glu Single submitter ⚠
- p.Lys253Ile Single submitter ⚠
- p.Met162Ile Single submitter ⚠
- p.Pro128Ala Single submitter ⚠
- p.Ser333Leu Single submitter ⚠
- p.Thr191Ser Single submitter ⚠
- p.Thr230Ser Single submitter ⚠
- p.Thr307Arg Single submitter ⚠
- p.Thr392Met Single submitter
- p.Trp140Cys Single submitter ⚠
- p.Trp363Arg Single submitter ⚠
- p.Trp363Leu Single submitter ⚠
- p.Tyr149Asp Single submitter ⚠
- p.Tyr149Cys Single submitter ⚠
- p.Tyr152Cys Single submitter ⚠
- p.Tyr262His Single submitter ⚠
- p.Val194Met Single submitter ⚠
- p.Val210Gly Single submitter ⚠
- p.Val241Leu Single submitter ⚠
- p.Val328Met Single submitter ⚠
- p.Val6Glu Single submitter ⚠
- p.Val6Met Single submitter ⚠