MRTO4 — 38 ClinVar variants
All ClinVar germline MRTO4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
38 Uncertain significance
Full MRTO4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MRTO4 p.Ala59Thr Uncertain significance Single submitter
- MRTO4 p.Arg126Leu Uncertain significance Single submitter
- MRTO4 p.Arg126Pro Uncertain significance Single submitter
- MRTO4 p.Arg214Ser Uncertain significance Single submitter
- MRTO4 p.Arg57Gln Uncertain significance Single submitter
- MRTO4 p.Asp123Gly Uncertain significance Single submitter
- MRTO4 p.Asp138Glu Uncertain significance Single submitter
- MRTO4 p.Gln186His Uncertain significance Single submitter
- MRTO4 p.Gln186Pro Uncertain significance Single submitter
- MRTO4 p.Gln217Arg Uncertain significance Single submitter
- MRTO4 p.Glu150Gln Uncertain significance Single submitter
- MRTO4 p.Glu196Gln Uncertain significance Single submitter
- MRTO4 p.His90Tyr Uncertain significance Single submitter
- MRTO4 p.Leu156Pro Uncertain significance Single submitter
- MRTO4 p.Leu192His Uncertain significance Single submitter
- MRTO4 p.Leu40Ile Uncertain significance Single submitter
- MRTO4 p.Leu77Phe Uncertain significance Single submitter
- MRTO4 p.Lys38Glu Uncertain significance Single submitter
- MRTO4 p.Lys3Arg Uncertain significance Single submitter
- MRTO4 p.Lys8Thr Uncertain significance Single submitter
- MRTO4 p.Met74Val Uncertain significance Single submitter
- MRTO4 p.Pro2Arg Uncertain significance Single submitter
- MRTO4 p.Trp115Ser Uncertain significance Single submitter
- MRTO4 p.Tyr206His Uncertain significance Single submitter
- MRTO4 p.Val167Ala Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- MRTO4 p.Arg107Ser Uncertain significance Single submitter
- MRTO4 p.Arg188His Uncertain significance Single submitter
- MRTO4 p.Arg79Gln Uncertain significance Single submitter
- MRTO4 p.Arg79Trp Uncertain significance Single submitter
- MRTO4 p.Asn88Lys Uncertain significance Single submitter
- MRTO4 p.Asp180Asn Uncertain significance Single submitter
- MRTO4 p.Leu26Val Uncertain significance Single submitter
- MRTO4 p.Ser229Phe Uncertain significance Single submitter
- MRTO4 p.Ser51Arg Uncertain significance Single submitter
- MRTO4 p.Tyr85His Uncertain significance Single submitter
- MRTO4 p.Val100Ala Uncertain significance Single submitter
All MRTO4 variants
Uncertain significance 38
- c.493+2T>A Single submitter
- p.Ala59Thr Single submitter ⚠
- p.Arg107Ser Single submitter ⚠
- p.Arg126Leu Single submitter ⚠
- p.Arg126Pro Single submitter ⚠
- p.Arg188His Single submitter ⚠
- p.Arg214Ser Single submitter ⚠
- p.Arg57Gln Single submitter ⚠
- p.Arg79Gln Single submitter ⚠
- p.Arg79Trp Single submitter ⚠
- p.Asn88Lys Single submitter ⚠
- p.Asp123Gly Single submitter ⚠
- p.Asp138Glu Single submitter ⚠
- p.Asp180Asn Single submitter ⚠
- p.Gln186His Single submitter ⚠
- p.Gln186Pro Single submitter ⚠
- p.Gln217Arg Single submitter ⚠
- p.Glu150Gln Single submitter ⚠
- p.Glu178Gly Single submitter
- p.Glu196Gln Single submitter ⚠
- p.His90Tyr Single submitter ⚠
- p.Leu156Pro Single submitter ⚠
- p.Leu192His Single submitter ⚠
- p.Leu26Val Single submitter ⚠
- p.Leu40Ile Single submitter ⚠
- p.Leu77Phe Single submitter ⚠
- p.Lys38Glu Single submitter ⚠
- p.Lys3Arg Single submitter ⚠
- p.Lys8Thr Single submitter ⚠
- p.Met74Val Single submitter ⚠
- p.Pro2Arg Single submitter ⚠
- p.Ser229Phe Single submitter ⚠
- p.Ser51Arg Single submitter ⚠
- p.Trp115Ser Single submitter ⚠
- p.Tyr206His Single submitter ⚠
- p.Tyr85His Single submitter ⚠
- p.Val100Ala Single submitter ⚠
- p.Val167Ala Single submitter ⚠