Sugi Variant

Sugi Variant/MSN

MSN — 280 ClinVar variants

All ClinVar germline MSN variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 113 flagged for review →

12 Pathogenic · 7 Likely pathogenic · 10 Conflicting · 24 Benign · 10 Benign/Likely benign · 96 Likely benign · 121 Uncertain significance

Full MSN gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 113

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 6

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 83

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 24

The independent predictors disagree with each other — read with care.

All MSN variants

Pathogenic 12

Likely pathogenic 7

Conflicting classifications of pathogenicity 10

Benign 24

Benign/Likely benign 10

Likely benign 96

Uncertain significance 121