MYADM — 46 ClinVar variants
All ClinVar germline MYADM variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
1 Likely benign · 45 Uncertain significance
Full MYADM gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MYADM p.Ala297Val Uncertain significance Single submitter
- MYADM p.Ala306Thr Uncertain significance Single submitter
- MYADM p.Ala306Val Uncertain significance Single submitter
- MYADM p.Arg161Gln Uncertain significance Single submitter
- MYADM p.Arg40Cys Uncertain significance Single submitter
- MYADM p.Asn195Asp Uncertain significance Single submitter
- MYADM p.Cys185Arg Uncertain significance Single submitter
- MYADM p.Gly131Ser Uncertain significance Single submitter
- MYADM p.His130Arg Uncertain significance Single submitter
- MYADM p.Ile119Val Uncertain significance Single submitter
- MYADM p.Ile82Met Uncertain significance Single submitter
- MYADM p.Leu114Pro Uncertain significance Single submitter
- MYADM p.Leu176Pro Uncertain significance Single submitter
- MYADM p.Leu240Val Uncertain significance Single submitter
- MYADM p.Leu250Phe Uncertain significance Single submitter
- MYADM p.Leu87Val Uncertain significance Single submitter
- MYADM p.Lys266Asn Uncertain significance Single submitter
- MYADM p.Phe188Val Uncertain significance Single submitter
- MYADM p.Phe214Leu Uncertain significance Single submitter
- MYADM p.Pro23Thr Uncertain significance Single submitter
- MYADM p.Ser18Leu Uncertain significance Single submitter
- MYADM p.Thr61Met Uncertain significance Single submitter
- MYADM p.Tyr285Phe Uncertain significance Single submitter
- MYADM p.Tyr307Ser Uncertain significance Single submitter
- MYADM p.Val231Leu Uncertain significance Single submitter
- MYADM p.Val248Ile Uncertain significance Single submitter
- MYADM p.Val49Met Uncertain significance Single submitter
- MYADM p.Val85Met Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- MYADM p.Ala137Thr Uncertain significance Single submitter
- MYADM p.Ala147Val Uncertain significance Single submitter
- MYADM p.Ala152Pro Uncertain significance Single submitter
- MYADM p.Ala217Val Uncertain significance Single submitter
- MYADM p.Arg132Cys Uncertain significance Single submitter
- MYADM p.Arg161Trp Uncertain significance Single submitter
- MYADM p.Arg7Cys Uncertain significance Single submitter
- MYADM p.Arg99Cys Uncertain significance Single submitter
- MYADM p.Cys145Tyr Uncertain significance Single submitter
- MYADM p.Gly242Glu Uncertain significance Single submitter
- MYADM p.Phe101Leu Uncertain significance Single submitter
- MYADM p.Pro102His Uncertain significance Single submitter
- MYADM p.Thr71Ile Uncertain significance Single submitter
- MYADM p.Tyr210Phe Uncertain significance Single submitter
- MYADM p.Tyr261Ser Uncertain significance Single submitter
- MYADM p.Tyr285Cys Uncertain significance Single submitter
All MYADM variants
Likely benign 1
- p.Arg281His Single submitter
Uncertain significance 45
- p.Ala137Thr Single submitter ⚠
- p.Ala147Val Single submitter ⚠
- p.Ala152Pro Single submitter ⚠
- p.Ala217Val Single submitter ⚠
- p.Ala297Val Single submitter ⚠
- p.Ala306Thr Single submitter ⚠
- p.Ala306Val Single submitter ⚠
- p.Arg132Cys Single submitter ⚠
- p.Arg161Gln Single submitter ⚠
- p.Arg161Trp Single submitter ⚠
- p.Arg40Cys Single submitter ⚠
- p.Arg7Cys Single submitter ⚠
- p.Arg99Cys Single submitter ⚠
- p.Asn195Asp Single submitter ⚠
- p.Cys145Tyr Single submitter ⚠
- p.Cys185Arg Single submitter ⚠
- p.Gly131Ser Single submitter ⚠
- p.Gly242Glu Single submitter ⚠
- p.Gly89Arg Single submitter
- p.His130Arg Single submitter ⚠
- p.Ile119Val Single submitter ⚠
- p.Ile82Met Single submitter ⚠
- p.Leu114Pro Single submitter ⚠
- p.Leu176Pro Single submitter ⚠
- p.Leu240Val Single submitter ⚠
- p.Leu250Phe Single submitter ⚠
- p.Leu87Val Single submitter ⚠
- p.Lys266Asn Single submitter ⚠
- p.Phe101Leu Single submitter ⚠
- p.Phe188Val Single submitter ⚠
- p.Phe214Leu Single submitter ⚠
- p.Pro102His Single submitter ⚠
- p.Pro23Thr Single submitter ⚠
- p.Ser18Leu Single submitter ⚠
- p.Thr61Met Single submitter ⚠
- p.Thr71Ile Single submitter ⚠
- p.Tyr210Phe Single submitter ⚠
- p.Tyr261Ser Single submitter ⚠
- p.Tyr285Cys Single submitter ⚠
- p.Tyr285Phe Single submitter ⚠
- p.Tyr307Ser Single submitter ⚠
- p.Val231Leu Single submitter ⚠
- p.Val248Ile Single submitter ⚠
- p.Val49Met Single submitter ⚠
- p.Val85Met Single submitter ⚠