MYC — 24 ClinVar variants
All ClinVar germline MYC variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 11 flagged for review →
4 Pathogenic · 5 Benign · 2 Benign/Likely benign · 2 Likely benign · 11 Uncertain significance
Full MYC gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 11
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors vs ClinVar 2
ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.
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MYC p.Asn101Thr
Pathogenic
No assertion criteria
Burkitt lymphoma
-
MYC p.Glu54Asp
Pathogenic
No assertion criteria
Burkitt lymphoma
Predictors lean, ClinVar uncertain 8
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
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MYC p.Asn26Ser
Uncertain significance
Multiple submitters
classic Hodgkin lymphoma
- MYC p.Ala224Val Uncertain significance Single submitter
- MYC p.Ala230Ser Uncertain significance Single submitter
- MYC p.Glu137Gln Uncertain significance Single submitter
- MYC p.Glu272Lys Uncertain significance Single submitter
- MYC p.Gly182Ser Uncertain significance Single submitter
- MYC p.Ile410Val Uncertain significance Single submitter
- MYC p.Ser303Arg Uncertain significance Single submitter
Predictors split 1
The independent predictors disagree with each other — read with care.
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MYC p.Pro72Ser
Pathogenic
No assertion criteria
Burkitt lymphoma
All MYC variants
Pathogenic 4
- p.Thr73Ala Single submitter
- p.Asn101Thr No assertion criteria Burkitt lymphoma ⚠
- p.Glu54Asp No assertion criteria Burkitt lymphoma ⚠
- p.Pro72Ser No assertion criteria Burkitt lymphoma ⚠
Benign 5
- p.Gln48= Multiple submitters
- c.30+600C>T Single submitter
- c.31-172G>A Single submitter
- c.-96C>T Single submitter
- p.Pro246= No assertion criteria MYC-related disorder
Benign/Likely benign 2
- p.Phe22Leu Multiple submitters
- p.Ser362Phe Multiple submitters
Uncertain significance 11
- p.Asn26Ser Multiple submitters classic Hodgkin lymphoma ⚠
- c.30+4A>T Single submitter
- p.Ala224Val Single submitter ⚠
- p.Ala230Ser Single submitter ⚠
- p.Asp433His Single submitter
- p.Glu137Gln Single submitter ⚠
- p.Glu272Lys Single submitter ⚠
- p.Gly182Ser Single submitter ⚠
- p.Ile410Val Single submitter ⚠
- p.Ser303Arg Single submitter ⚠
- p.Val160Ile Single submitter primary ovarian failure