MYL6 — 14 ClinVar variants
All ClinVar germline MYL6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 10 flagged for review →
2 Likely benign · 12 Uncertain significance
Full MYL6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 10
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 10
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- MYL6 p.Arg110Trp Uncertain significance Single submitter
- MYL6 p.Asn80Ser Uncertain significance Single submitter
- MYL6 p.Glu47Lys Uncertain significance Single submitter
- MYL6 p.Gly117Asp Uncertain significance Single submitter
- MYL6 p.Lys63Glu Uncertain significance Single submitter
- MYL6 p.Met36Val Uncertain significance Single submitter
- MYL6 p.Phe144Ser Uncertain significance Single submitter
- MYL6 p.Thr103Pro Uncertain significance Single submitter
- MYL6 p.Val114Leu Uncertain significance Single submitter
- MYL6 p.Val129Leu Uncertain significance Single submitter
All MYL6 variants
Likely benign 2
- p.Ala143= Single submitter
- c.*16+4C>T No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
Uncertain significance 12
- p.Arg110Trp Single submitter ⚠
- p.Asn80Ser Single submitter ⚠
- p.Glu47Lys Single submitter ⚠
- p.Gly117Asp Single submitter ⚠
- p.Lys63Glu Single submitter ⚠
- p.Met36Val Single submitter ⚠
- p.Phe144Ser Single submitter ⚠
- p.Ser150Leu Single submitter
- p.Thr103Pro Single submitter ⚠
- p.Thr76Arg Single submitter
- p.Val114Leu Single submitter ⚠
- p.Val129Leu Single submitter ⚠