Sugi Variant

Sugi Variant/MYOC

MYOC — 328 ClinVar variants

All ClinVar germline MYOC variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 151 flagged for review →

14 Pathogenic · 35 Likely pathogenic · 22 Benign · 53 Likely benign · 204 Uncertain significance

Full MYOC gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 151

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 5

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors lean, ClinVar uncertain 96

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 50

The independent predictors disagree with each other — read with care.

All MYOC variants

Pathogenic 14

Likely pathogenic 35

Benign 22

Likely benign 53

Uncertain significance 204