Sugi Variant

Sugi Variant/MYT1

MYT1 — 205 ClinVar variants

All ClinVar germline MYT1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 125 flagged for review →

1 Likely pathogenic · 13 Benign · 5 Benign/Likely benign · 59 Likely benign · 127 Uncertain significance

Full MYT1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 125

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors lean, ClinVar uncertain 111

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 13

The independent predictors disagree with each other — read with care.

All MYT1 variants

Likely pathogenic 1

Benign 13

Benign/Likely benign 5

Likely benign 59

Uncertain significance 127