NAPA — 42 ClinVar variants
All ClinVar germline NAPA variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 38 flagged for review →
1 Likely benign · 41 Uncertain significance
Full NAPA gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 38
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NAPA p.Ala202Thr Uncertain significance Single submitter
- NAPA p.Ala210Gly Uncertain significance Single submitter
- NAPA p.Ala46Thr Uncertain significance Single submitter
- NAPA p.Ala64Thr Uncertain significance Single submitter
- NAPA p.Ala68Ser Uncertain significance Single submitter
- NAPA p.Ala95Asp Uncertain significance Single submitter
- NAPA p.Arg116Gln Uncertain significance Single submitter
- NAPA p.Arg239Gln Uncertain significance Single submitter
- NAPA p.Arg239Trp Uncertain significance Single submitter
- NAPA p.Arg271Gln Uncertain significance Single submitter
- NAPA p.Asn23Lys Uncertain significance Single submitter
- NAPA p.Asp293Tyr Uncertain significance Single submitter
- NAPA p.Glu252Lys Uncertain significance Single submitter
- NAPA p.His124Arg Uncertain significance Single submitter
- NAPA p.Ile108Val Uncertain significance Single submitter
- NAPA p.Leu13Pro Uncertain significance Single submitter
- NAPA p.Lys153Arg Uncertain significance Single submitter
- NAPA p.Lys203Arg Uncertain significance Single submitter
- NAPA p.Met114Thr Uncertain significance Single submitter
- NAPA p.Met51Val Uncertain significance Single submitter
- NAPA p.Phe235Leu Uncertain significance Single submitter
- NAPA p.Thr278Ile Uncertain significance Single submitter
- NAPA p.Tyr111Cys Uncertain significance Single submitter
- NAPA p.Tyr205Asp Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- NAPA p.Ala172Thr Uncertain significance Single submitter
- NAPA p.Arg295Cys Uncertain significance Single submitter
- NAPA p.Asn90Ile Uncertain significance Single submitter
- NAPA p.Asp194Asn Uncertain significance Single submitter
- NAPA p.Asp80Asn Uncertain significance Single submitter
- NAPA p.Asp96Asn Uncertain significance Single submitter
- NAPA p.Glu261Lys Uncertain significance Single submitter
- NAPA p.Glu43Lys Uncertain significance Single submitter
- NAPA p.Ile130Leu Uncertain significance Single submitter
- NAPA p.Leu198Phe Uncertain significance Single submitter
- NAPA p.Phe206Leu Uncertain significance Single submitter
- NAPA p.Phe28Leu Uncertain significance Single submitter
- NAPA p.Ser195Arg Uncertain significance Single submitter
- NAPA p.Ser262Leu Uncertain significance Single submitter
All NAPA variants
Likely benign 1
- p.Asp87= Single submitter
Uncertain significance 41
- p.Ala172Thr Single submitter ⚠
- p.Ala202Thr Single submitter ⚠
- p.Ala210Gly Single submitter ⚠
- p.Ala46Thr Single submitter ⚠
- p.Ala64Thr Single submitter ⚠
- p.Ala68Ser Single submitter ⚠
- p.Ala91Thr Single submitter
- p.Ala95Asp Single submitter ⚠
- p.Arg116Gln Single submitter ⚠
- p.Arg239Gln Single submitter ⚠
- p.Arg239Trp Single submitter ⚠
- p.Arg271Gln Single submitter ⚠
- p.Arg295Cys Single submitter ⚠
- p.Asn23Lys Single submitter ⚠
- p.Asn90Ile Single submitter ⚠
- p.Asp194Asn Single submitter ⚠
- p.Asp293Asn Single submitter
- p.Asp293Tyr Single submitter ⚠
- p.Asp80Asn Single submitter ⚠
- p.Asp96Asn Single submitter ⚠
- p.Glu252Lys Single submitter ⚠
- p.Glu261Lys Single submitter ⚠
- p.Glu43Lys Single submitter ⚠
- p.His124Arg Single submitter ⚠
- p.Ile108Val Single submitter ⚠
- p.Ile130Leu Single submitter ⚠
- p.Leu13Pro Single submitter ⚠
- p.Leu198Phe Single submitter ⚠
- p.Lys153Arg Single submitter ⚠
- p.Lys203Arg Single submitter ⚠
- p.Met114Thr Single submitter ⚠
- p.Met51Val Single submitter ⚠
- p.Phe206Leu Single submitter ⚠
- p.Phe206Tyr Single submitter
- p.Phe235Leu Single submitter ⚠
- p.Phe28Leu Single submitter ⚠
- p.Ser195Arg Single submitter ⚠
- p.Ser262Leu Single submitter ⚠
- p.Thr278Ile Single submitter ⚠
- p.Tyr111Cys Single submitter ⚠
- p.Tyr205Asp Single submitter ⚠