NDUFB1 — 8 ClinVar variants
All ClinVar germline NDUFB1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 6 flagged for review →
8 Uncertain significance
Full NDUFB1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 6
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 3
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 3
The independent predictors disagree with each other — read with care.
All NDUFB1 variants
Uncertain significance 8
- c.-11C>T Single submitter
- c.-36C>T Single submitter
- p.Arg34Trp Single submitter ⚠
- p.Arg39Gln Single submitter ⚠
- p.Arg39Pro Single submitter ⚠
- p.Asp10Tyr Single submitter ⚠
- p.Lys41Glu Single submitter ⚠
- p.Pro51Ala Single submitter ⚠