NDUFB2 — 11 ClinVar variants
All ClinVar germline NDUFB2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 10 flagged for review →
11 Uncertain significance
Full NDUFB2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 10
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NDUFB2 p.Arg52Lys Uncertain significance Single submitter
- NDUFB2 p.Asp103Gly Uncertain significance Single submitter
- NDUFB2 p.Glu79Gln Uncertain significance Single submitter
- NDUFB2 p.Gly35Ser Uncertain significance Single submitter
- NDUFB2 p.Trp92Arg Uncertain significance Single submitter
- NDUFB2 p.Tyr44Cys Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All NDUFB2 variants
Uncertain significance 11
- p.Arg43Gln Single submitter ⚠
- p.Arg52Lys Single submitter ⚠
- p.Asp103Gly Single submitter ⚠
- p.Asp103His Single submitter ⚠
- p.Gln54His Single submitter ⚠
- p.Glu79Gln Single submitter ⚠
- p.Gly35Ser Single submitter ⚠
- p.Pro42Leu Single submitter ⚠
- p.Ter106Trp Single submitter
- p.Trp92Arg Single submitter ⚠
- p.Tyr44Cys Single submitter ⚠