NEU4 — 135 ClinVar variants
All ClinVar germline NEU4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 120 flagged for review →
7 Likely benign · 128 Uncertain significance
Full NEU4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 120
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 99
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NEU4 p.Ala128Ser Uncertain significance Single submitter
- NEU4 p.Ala139Ser Uncertain significance Single submitter
- NEU4 p.Ala139Thr Uncertain significance Single submitter
- NEU4 p.Ala150Thr Uncertain significance Single submitter
- NEU4 p.Ala158Thr Uncertain significance Single submitter
- NEU4 p.Ala176Pro Uncertain significance Single submitter
- NEU4 p.Ala176Thr Uncertain significance Single submitter
- NEU4 p.Ala287Thr Uncertain significance Single submitter
- NEU4 p.Ala321Val Uncertain significance Single submitter
- NEU4 p.Ala370Pro Uncertain significance Single submitter
- NEU4 p.Ala423Val Uncertain significance Single submitter
- NEU4 p.Ala428Val Uncertain significance Single submitter
- NEU4 p.Ala62Ser Uncertain significance Single submitter
- NEU4 p.Ala78Val Uncertain significance Single submitter
- NEU4 p.Ala93Pro Uncertain significance Single submitter
- NEU4 p.Arg123His Uncertain significance Single submitter
- NEU4 p.Arg130Cys Uncertain significance Single submitter
- NEU4 p.Arg140Gln Uncertain significance Single submitter
- NEU4 p.Arg140Pro Uncertain significance Single submitter
- NEU4 p.Arg171Cys Uncertain significance Single submitter
- NEU4 p.Arg171Pro Uncertain significance Single submitter
- NEU4 p.Arg17Lys Uncertain significance Single submitter
- NEU4 p.Arg184Gln Uncertain significance Single submitter
- NEU4 p.Arg192Gln Uncertain significance Single submitter
- NEU4 p.Arg207Cys Uncertain significance Single submitter
- NEU4 p.Arg210Cys Uncertain significance Single submitter
- NEU4 p.Arg219His Uncertain significance Single submitter
- NEU4 p.Arg23Cys Uncertain significance Single submitter
- NEU4 p.Arg248Cys Uncertain significance Single submitter
- NEU4 p.Arg248His Uncertain significance Single submitter
- NEU4 p.Arg265Cys Uncertain significance Single submitter
- NEU4 p.Arg265His Uncertain significance Single submitter
- NEU4 p.Arg292Gln Uncertain significance Single submitter
- NEU4 p.Arg292Trp Uncertain significance Single submitter
- NEU4 p.Arg340Trp Uncertain significance Single submitter
- NEU4 p.Arg386His Uncertain significance Single submitter
- NEU4 p.Arg395His Uncertain significance Single submitter
- NEU4 p.Arg43Gln Uncertain significance Single submitter
- NEU4 p.Arg458Ser Uncertain significance Single submitter
- NEU4 p.Arg478Gln Uncertain significance Single submitter
- NEU4 p.Arg478Trp Uncertain significance Single submitter
- NEU4 p.Arg83Leu Uncertain significance Single submitter
- NEU4 p.Asp204Glu Uncertain significance Single submitter
- NEU4 p.Asp421Asn Uncertain significance Single submitter
- NEU4 p.Gln152Lys Uncertain significance Single submitter
- NEU4 p.Gln42Arg Uncertain significance Single submitter
- NEU4 p.Glu16Gly Uncertain significance Single submitter
- NEU4 p.Glu256Lys Uncertain significance Single submitter
- NEU4 p.Glu271Lys Uncertain significance Single submitter
- NEU4 p.Glu440Gln Uncertain significance Single submitter
- NEU4 p.Gly118Glu Uncertain significance Single submitter
- NEU4 p.Gly133Ser Uncertain significance Single submitter
- NEU4 p.Gly164Cys Uncertain significance Single submitter
- NEU4 p.Gly213Ser Uncertain significance Single submitter
- NEU4 p.Gly230Ser Uncertain significance Single submitter
- NEU4 p.Gly331Ser Uncertain significance Single submitter
- NEU4 p.Gly431Arg Uncertain significance Single submitter
- NEU4 p.Gly431Glu Uncertain significance Single submitter
- NEU4 p.Gly442Arg Uncertain significance Single submitter
- NEU4 p.Gly59Ser Uncertain significance Single submitter
- NEU4 p.Gly63Arg Uncertain significance Single submitter
- NEU4 p.His382Gln Uncertain significance Single submitter
- NEU4 p.Ile280Val Uncertain significance Single submitter
- NEU4 p.Leu106Val Uncertain significance Single submitter
- NEU4 p.Leu12Pro Uncertain significance Single submitter
- NEU4 p.Leu142Ile Uncertain significance Single submitter
- NEU4 p.Leu172Val Uncertain significance Single submitter
- NEU4 p.Leu252Val Uncertain significance Single submitter
- NEU4 p.Phe236Ser Uncertain significance Single submitter
- NEU4 p.Phe368Ser Uncertain significance Single submitter
- NEU4 p.Pro25Arg Uncertain significance Single submitter
- NEU4 p.Pro262Leu Uncertain significance Single submitter
- NEU4 p.Pro29Ser Uncertain significance Single submitter
- NEU4 p.Pro307Leu Uncertain significance Single submitter
- NEU4 p.Pro349Leu Uncertain significance Single submitter
- NEU4 p.Pro365Ser Uncertain significance Single submitter
- NEU4 p.Pro427Leu Uncertain significance Single submitter
- NEU4 p.Pro427Ser Uncertain significance Single submitter
- NEU4 p.Pro468Ala Uncertain significance Single submitter
- NEU4 p.Pro468Leu Uncertain significance Single submitter
- NEU4 p.Pro470Leu Uncertain significance Single submitter
- NEU4 p.Pro477Thr Uncertain significance Single submitter
- NEU4 p.Pro87Ala Uncertain significance Single submitter
- NEU4 p.Pro89Ser Uncertain significance Single submitter
- NEU4 p.Ser194Gly Uncertain significance Single submitter
- NEU4 p.Ser253Gly Uncertain significance Single submitter
- NEU4 p.Ser335Gly Uncertain significance Single submitter
- NEU4 p.Thr117Met Uncertain significance Single submitter
- NEU4 p.Thr258Ser Uncertain significance Single submitter
- NEU4 p.Trp482Cys Uncertain significance Single submitter
- NEU4 p.Trp482Leu Uncertain significance Single submitter
- NEU4 p.Tyr22His Uncertain significance Single submitter
- NEU4 p.Val113Met Uncertain significance Single submitter
- NEU4 p.Val151Met Uncertain significance Single submitter
- NEU4 p.Val165Met Uncertain significance Single submitter
- NEU4 p.Val24Met Uncertain significance Single submitter
- NEU4 p.Val298Ala Uncertain significance Single submitter
- NEU4 p.Val464Met Uncertain significance Single submitter
- NEU4 p.Val73Leu Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- NEU4 p.Arg140Trp Uncertain significance Single submitter
- NEU4 p.Arg458Cys Uncertain significance Single submitter
- NEU4 p.Arg9Trp Uncertain significance Single submitter
- NEU4 p.Asp203Asn Uncertain significance Single submitter
- NEU4 p.Cys223Ser Uncertain significance Single submitter
- NEU4 p.Gly234Ser Uncertain significance Single submitter
- NEU4 p.Gly426Arg Uncertain significance Single submitter
- NEU4 p.Gly431Trp Uncertain significance Single submitter
- NEU4 p.His50Tyr Uncertain significance Single submitter
- NEU4 p.Met392Val Uncertain significance Single submitter
- NEU4 p.Phe198Leu Uncertain significance Single submitter
- NEU4 p.Pro403Leu Uncertain significance Single submitter
- NEU4 p.Ser135Leu Uncertain significance Single submitter
- NEU4 p.Ser268Phe Uncertain significance Single submitter
- NEU4 p.Ser26Leu Uncertain significance Single submitter
- NEU4 p.Thr109Met Uncertain significance Single submitter
- NEU4 p.Thr35Pro Uncertain significance Single submitter
- NEU4 p.Thr60Met Uncertain significance Single submitter
- NEU4 p.Trp410Cys Uncertain significance Single submitter
- NEU4 p.Val30Met Uncertain significance Single submitter
- NEU4 p.Val73Met Uncertain significance Single submitter
All NEU4 variants
Likely benign 7
- p.Ala150= Single submitter
- p.Arg210His Single submitter
- p.Arg404His Single submitter
- p.Arg5His Single submitter
- p.Glu144Lys Single submitter
- p.Gly432Ala Single submitter
- p.Ile280= Single submitter
Uncertain significance 128
- c.-4+2162G>A Single submitter
- p.Ala128Ser Single submitter ⚠
- p.Ala139Ser Single submitter ⚠
- p.Ala139Thr Single submitter ⚠
- p.Ala150Thr Single submitter ⚠
- p.Ala158Thr Single submitter ⚠
- p.Ala176Pro Single submitter ⚠
- p.Ala176Thr Single submitter ⚠
- p.Ala285Asp Single submitter
- p.Ala287Thr Single submitter ⚠
- p.Ala321Val Single submitter ⚠
- p.Ala370Pro Single submitter ⚠
- p.Ala423Val Single submitter ⚠
- p.Ala428Val Single submitter ⚠
- p.Ala62Ser Single submitter ⚠
- p.Ala78Val Single submitter ⚠
- p.Ala93Pro Single submitter ⚠
- p.Arg123Cys Single submitter
- p.Arg123His Single submitter ⚠
- p.Arg130Cys Single submitter ⚠
- p.Arg140Gln Single submitter ⚠
- p.Arg140Pro Single submitter ⚠
- p.Arg140Trp Single submitter ⚠
- p.Arg171Cys Single submitter ⚠
- p.Arg171Pro Single submitter ⚠
- p.Arg17Lys Single submitter ⚠
- p.Arg184Gln Single submitter ⚠
- p.Arg192Gln Single submitter ⚠
- p.Arg207Cys Single submitter ⚠
- p.Arg210Cys Single submitter ⚠
- p.Arg219His Single submitter ⚠
- p.Arg23Cys Single submitter ⚠
- p.Arg248Cys Single submitter ⚠
- p.Arg248His Single submitter ⚠
- p.Arg265Cys Single submitter ⚠
- p.Arg265His Single submitter ⚠
- p.Arg292Gln Single submitter ⚠
- p.Arg292Trp Single submitter ⚠
- p.Arg340Trp Single submitter ⚠
- p.Arg386His Single submitter ⚠
- p.Arg395His Single submitter ⚠
- p.Arg43Gln Single submitter ⚠
- p.Arg458Cys Single submitter ⚠
- p.Arg458Ser Single submitter ⚠
- p.Arg478Gln Single submitter ⚠
- p.Arg478Trp Single submitter ⚠
- p.Arg83Leu Single submitter ⚠
- p.Arg9Trp Single submitter ⚠
- p.Asp203Asn Single submitter ⚠
- p.Asp204Glu Single submitter ⚠
- p.Asp421Asn Single submitter ⚠
- p.Cys126Arg Single submitter
- p.Cys223Ser Single submitter ⚠
- p.Cys453Arg Single submitter
- p.Gln152Lys Single submitter ⚠
- p.Gln42Arg Single submitter ⚠
- p.Glu16Gly Single submitter ⚠
- p.Glu256Lys Single submitter ⚠
- p.Glu271Lys Single submitter ⚠
- p.Glu440Gln Single submitter ⚠
- p.Gly118Glu Single submitter ⚠
- p.Gly133Ser Single submitter ⚠
- p.Gly164Cys Single submitter ⚠
- p.Gly213Ser Single submitter ⚠
- p.Gly230Ser Single submitter ⚠
- p.Gly234Ser Single submitter ⚠
- p.Gly331Ser Single submitter ⚠
- p.Gly426Arg Single submitter ⚠
- p.Gly431Arg Single submitter ⚠
- p.Gly431Glu Single submitter ⚠
- p.Gly431Trp Single submitter ⚠
- p.Gly442Arg Single submitter ⚠
- p.Gly59Ser Single submitter ⚠
- p.Gly63Arg Single submitter ⚠
- p.His382Gln Single submitter ⚠
- p.His50Tyr Single submitter ⚠
- p.Ile280Val Single submitter ⚠
- p.Ile412Met Single submitter
- p.Leu106Val Single submitter ⚠
- p.Leu12Pro Single submitter ⚠
- p.Leu142Ile Single submitter ⚠
- p.Leu172Val Single submitter ⚠
- p.Leu252Val Single submitter ⚠
- p.Met392Val Single submitter ⚠
- p.Phe198Leu Single submitter ⚠
- p.Phe236Ser Single submitter ⚠
- p.Phe368Ser Single submitter ⚠
- p.Pro25Arg Single submitter ⚠
- p.Pro262Leu Single submitter ⚠
- p.Pro29Ser Single submitter ⚠
- p.Pro307Leu Single submitter ⚠
- p.Pro349Leu Single submitter ⚠
- p.Pro365Ser Single submitter ⚠
- p.Pro400Leu Single submitter
- p.Pro403Leu Single submitter ⚠
- p.Pro427Leu Single submitter ⚠
- p.Pro427Ser Single submitter ⚠
- p.Pro468Ala Single submitter ⚠
- p.Pro468Leu Single submitter ⚠
- p.Pro470Leu Single submitter ⚠
- p.Pro477Thr Single submitter ⚠
- p.Pro87Ala Single submitter ⚠
- p.Pro89Ser Single submitter ⚠
- p.Ser135Leu Single submitter ⚠
- p.Ser194Gly Single submitter ⚠
- p.Ser253Gly Single submitter ⚠
- p.Ser268Phe Single submitter ⚠
- p.Ser26Leu Single submitter ⚠
- p.Ser335Gly Single submitter ⚠
- p.Thr109Met Single submitter ⚠
- p.Thr117Met Single submitter ⚠
- p.Thr258Ser Single submitter ⚠
- p.Thr35Pro Single submitter ⚠
- p.Thr60Met Single submitter ⚠
- p.Trp410Cys Single submitter ⚠
- p.Trp482Cys Single submitter ⚠
- p.Trp482Leu Single submitter ⚠
- p.Tyr22His Single submitter ⚠
- p.Val113Met Single submitter ⚠
- p.Val151Met Single submitter ⚠
- p.Val165Ala Single submitter
- p.Val165Met Single submitter ⚠
- p.Val24Met Single submitter ⚠
- p.Val298Ala Single submitter ⚠
- p.Val30Met Single submitter ⚠
- p.Val464Met Single submitter ⚠
- p.Val73Leu Single submitter ⚠
- p.Val73Met Single submitter ⚠