NIT2 — 33 ClinVar variants
All ClinVar germline NIT2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
1 Likely benign · 32 Uncertain significance
Full NIT2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NIT2 p.Ala209Val Uncertain significance Single submitter
- NIT2 p.Ala51Gly Uncertain significance Single submitter
- NIT2 p.Ala51Val Uncertain significance Single submitter
- NIT2 p.Arg157Gln Uncertain significance Single submitter
- NIT2 p.Arg195Trp Uncertain significance Single submitter
- NIT2 p.Arg255Cys Uncertain significance Single submitter
- NIT2 p.Asp155Gly Uncertain significance Single submitter
- NIT2 p.Cys170Phe Uncertain significance Single submitter
- NIT2 p.Cys44Tyr Uncertain significance Single submitter
- NIT2 p.Gln67His Uncertain significance Single submitter
- NIT2 p.Glu128Gly Uncertain significance Single submitter
- NIT2 p.His221Pro Uncertain significance Single submitter
- NIT2 p.Ile118Phe Uncertain significance Single submitter
- NIT2 p.Ile16Val Uncertain significance Single submitter
- NIT2 p.Ile85Val Uncertain significance Single submitter
- NIT2 p.Leu161Ile Uncertain significance Single submitter
- NIT2 p.Met156Thr Uncertain significance Single submitter
- NIT2 p.Phe27Ser Uncertain significance Single submitter
- NIT2 p.Pro134Leu Uncertain significance Single submitter
- NIT2 p.Pro86Ser Uncertain significance Single submitter
- NIT2 p.Ser47Phe Uncertain significance Single submitter
- NIT2 p.Ser84Ala Uncertain significance Single submitter
- NIT2 p.Thr237Ser Uncertain significance Single submitter
- NIT2 p.Val120Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- NIT2 p.Arg23Cys Uncertain significance Single submitter
- NIT2 p.Arg29Trp Uncertain significance Single submitter
- NIT2 p.Asp136Gly Uncertain significance Single submitter
- NIT2 p.Leu6Phe Uncertain significance Single submitter
- NIT2 p.Thr96Ala Uncertain significance Single submitter
- NIT2 p.Tyr110Ser Uncertain significance Single submitter
- NIT2 p.Val260Ala Uncertain significance Single submitter
All NIT2 variants
Likely benign 1
- p.Thr2Ala Single submitter
Uncertain significance 32
- p.Ala209Val Single submitter ⚠
- p.Ala51Gly Single submitter ⚠
- p.Ala51Val Single submitter ⚠
- p.Arg157Gln Single submitter ⚠
- p.Arg195Trp Single submitter ⚠
- p.Arg210Trp Single submitter
- p.Arg23Cys Single submitter ⚠
- p.Arg255Cys Single submitter ⚠
- p.Arg29Trp Single submitter ⚠
- p.Asp136Gly Single submitter ⚠
- p.Asp155Gly Single submitter ⚠
- p.Cys170Phe Single submitter ⚠
- p.Cys44Tyr Single submitter ⚠
- p.Gln67His Single submitter ⚠
- p.Glu128Gly Single submitter ⚠
- p.His221Pro Single submitter ⚠
- p.Ile118Phe Single submitter ⚠
- p.Ile16Val Single submitter ⚠
- p.Ile85Val Single submitter ⚠
- p.Leu161Ile Single submitter ⚠
- p.Leu6Phe Single submitter ⚠
- p.Met156Thr Single submitter ⚠
- p.Phe27Ser Single submitter ⚠
- p.Pro134Leu Single submitter ⚠
- p.Pro86Ser Single submitter ⚠
- p.Ser47Phe Single submitter ⚠
- p.Ser84Ala Single submitter ⚠
- p.Thr237Ser Single submitter ⚠
- p.Thr96Ala Single submitter ⚠
- p.Tyr110Ser Single submitter ⚠
- p.Val120Ile Single submitter ⚠
- p.Val260Ala Single submitter ⚠