NMT2 — 59 ClinVar variants
All ClinVar germline NMT2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 57 flagged for review →
1 Likely benign · 58 Uncertain significance
Full NMT2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 57
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 46
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NMT2 p.Ala103Thr Uncertain significance Single submitter
- NMT2 p.Ala262Pro Uncertain significance Single submitter
- NMT2 p.Ala285Thr Uncertain significance Single submitter
- NMT2 p.Ala285Val Uncertain significance Single submitter
- NMT2 p.Ala420Thr Uncertain significance Single submitter
- NMT2 p.Ala440Val Uncertain significance Single submitter
- NMT2 p.Arg148Cys Uncertain significance Single submitter
- NMT2 p.Arg148His Uncertain significance Single submitter
- NMT2 p.Arg191Gln Uncertain significance Single submitter
- NMT2 p.Arg260Gln Uncertain significance Single submitter
- NMT2 p.Arg352Gln Uncertain significance Single submitter
- NMT2 p.Asp143Glu Uncertain significance Single submitter
- NMT2 p.Asp164Asn Uncertain significance Single submitter
- NMT2 p.Asp185Asn Uncertain significance Single submitter
- NMT2 p.Asp185Val Uncertain significance Single submitter
- NMT2 p.Asp369Glu Uncertain significance Single submitter
- NMT2 p.Asp435Glu Uncertain significance Single submitter
- NMT2 p.Asp489His Uncertain significance Single submitter
- NMT2 p.Asp93Val Uncertain significance Single submitter
- NMT2 p.Glu169Gln Uncertain significance Single submitter
- NMT2 p.Glu310Lys Uncertain significance Single submitter
- NMT2 p.Glu430Asp Uncertain significance Single submitter
- NMT2 p.Glu430Gln Uncertain significance Single submitter
- NMT2 p.Glu74Asp Uncertain significance Single submitter
- NMT2 p.Gly41Val Uncertain significance Single submitter
- NMT2 p.His411Tyr Uncertain significance Single submitter
- NMT2 p.His428Tyr Uncertain significance Single submitter
- NMT2 p.Ile348Thr Uncertain significance Single submitter
- NMT2 p.Ile442Val Uncertain significance Single submitter
- NMT2 p.Ile471Val Uncertain significance Single submitter
- NMT2 p.Lys468Gln Uncertain significance Single submitter
- NMT2 p.Met244Ile Uncertain significance Single submitter
- NMT2 p.Met343Thr Uncertain significance Single submitter
- NMT2 p.Met410Thr Uncertain significance Single submitter
- NMT2 p.Pro126Leu Uncertain significance Single submitter
- NMT2 p.Ser102Pro Uncertain significance Single submitter
- NMT2 p.Ser38Asn Uncertain significance Single submitter
- NMT2 p.Ser81Leu Uncertain significance Single submitter
- NMT2 p.Thr284Ile Uncertain significance Single submitter
- NMT2 p.Trp212Cys Uncertain significance Single submitter
- NMT2 p.Trp212Leu Uncertain significance Single submitter
- NMT2 p.Tyr175His Uncertain significance Single submitter
- NMT2 p.Val225Ala Uncertain significance Single submitter
- NMT2 p.Val288Ile Uncertain significance Single submitter
- NMT2 p.Val334Phe Uncertain significance Single submitter
- NMT2 p.Val496Ala Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- NMT2 p.Ala139Thr Uncertain significance Single submitter
- NMT2 p.Arg380Gln Likely benign Single submitter
- NMT2 p.Asn234Asp Uncertain significance Single submitter
- NMT2 p.Asn453Asp Uncertain significance Single submitter
- NMT2 p.Asn453Ser Uncertain significance Single submitter
- NMT2 p.Gln156Arg Uncertain significance Single submitter
- NMT2 p.Glu246Asp Uncertain significance Single submitter
- NMT2 p.Lys243Asn Uncertain significance Single submitter
- NMT2 p.Met244Leu Uncertain significance Single submitter
- NMT2 p.Pro413Leu Uncertain significance Single submitter
- NMT2 p.Thr397Ser Uncertain significance Single submitter
All NMT2 variants
Likely benign 1
- p.Arg380Gln Single submitter ⚠
Uncertain significance 58
- p.Ala103Thr Single submitter ⚠
- p.Ala139Thr Single submitter ⚠
- p.Ala233Thr Single submitter
- p.Ala262Pro Single submitter ⚠
- p.Ala285Thr Single submitter ⚠
- p.Ala285Val Single submitter ⚠
- p.Ala420Thr Single submitter ⚠
- p.Ala440Val Single submitter ⚠
- p.Arg148Cys Single submitter ⚠
- p.Arg148His Single submitter ⚠
- p.Arg191Gln Single submitter ⚠
- p.Arg260Gln Single submitter ⚠
- p.Arg352Gln Single submitter ⚠
- p.Asn234Asp Single submitter ⚠
- p.Asn453Asp Single submitter ⚠
- p.Asn453Ser Single submitter ⚠
- p.Asp143Glu Single submitter ⚠
- p.Asp164Asn Single submitter ⚠
- p.Asp185Asn Single submitter ⚠
- p.Asp185Val Single submitter ⚠
- p.Asp369Glu Single submitter ⚠
- p.Asp435Glu Single submitter ⚠
- p.Asp489His Single submitter ⚠
- p.Asp93Val Single submitter ⚠
- p.Gln156Arg Single submitter ⚠
- p.Glu169Gln Single submitter ⚠
- p.Glu246Asp Single submitter ⚠
- p.Glu310Lys Single submitter ⚠
- p.Glu430Asp Single submitter ⚠
- p.Glu430Gln Single submitter ⚠
- p.Glu74Asp Single submitter ⚠
- p.Gly41Val Single submitter ⚠
- p.His411Tyr Single submitter ⚠
- p.His428Tyr Single submitter ⚠
- p.Ile348Thr Single submitter ⚠
- p.Ile442Val Single submitter ⚠
- p.Ile471Val Single submitter ⚠
- p.Lys243Asn Single submitter ⚠
- p.Lys468Gln Single submitter ⚠
- p.Met244Ile Single submitter ⚠
- p.Met244Leu Single submitter ⚠
- p.Met343Thr Single submitter ⚠
- p.Met410Thr Single submitter ⚠
- p.Pro126Leu Single submitter ⚠
- p.Pro413Leu Single submitter ⚠
- p.Ser102Pro Single submitter ⚠
- p.Ser38Asn Single submitter ⚠
- p.Ser81Leu Single submitter ⚠
- p.Thr284Ile Single submitter ⚠
- p.Thr397Ser Single submitter ⚠
- p.Trp212Cys Single submitter ⚠
- p.Trp212Leu Single submitter ⚠
- p.Tyr175His Single submitter ⚠
- p.Val183Ile Single submitter
- p.Val225Ala Single submitter ⚠
- p.Val288Ile Single submitter ⚠
- p.Val334Phe Single submitter ⚠
- p.Val496Ala Single submitter ⚠