NOX3 — 93 ClinVar variants
All ClinVar germline NOX3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 85 flagged for review →
1 Benign · 4 Likely benign · 88 Uncertain significance
Full NOX3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 85
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 61
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NOX3 p.Ala106Thr Uncertain significance Single submitter
- NOX3 p.Ala119Glu Uncertain significance Single submitter
- NOX3 p.Ala141Thr Uncertain significance Single submitter
- NOX3 p.Ala247Glu Uncertain significance Single submitter
- NOX3 p.Ala318Val Uncertain significance Single submitter
- NOX3 p.Ala361Thr Uncertain significance Single submitter
- NOX3 p.Ala407Thr Uncertain significance Single submitter
- NOX3 p.Arg100Gly Uncertain significance Single submitter
- NOX3 p.Arg224Gln Uncertain significance Single submitter
- NOX3 p.Arg224Trp Uncertain significance Single submitter
- NOX3 p.Arg313Gly Uncertain significance Single submitter
- NOX3 p.Arg313His Uncertain significance Single submitter
- NOX3 p.Arg447Gly Uncertain significance Single submitter
- NOX3 p.Arg462Trp Uncertain significance Single submitter
- NOX3 p.Asn150Lys Uncertain significance Single submitter
- NOX3 p.Asn155Asp Uncertain significance Single submitter
- NOX3 p.Asn23Asp Uncertain significance Single submitter
- NOX3 p.Asp395Glu Uncertain significance Single submitter
- NOX3 p.Asp96His Uncertain significance Single submitter
- NOX3 p.Cys242Tyr Uncertain significance Single submitter
- NOX3 p.Cys280Arg Uncertain significance Single submitter
- NOX3 p.Cys443Phe Uncertain significance Single submitter
- NOX3 p.Cys65Arg Uncertain significance Single submitter
- NOX3 p.Gln136Arg Uncertain significance Single submitter
- NOX3 p.Gln259Lys Uncertain significance Single submitter
- NOX3 p.Gln321Lys Uncertain significance Single submitter
- NOX3 p.Gln326Arg Uncertain significance Single submitter
- NOX3 p.Gln545Arg Uncertain significance Single submitter
- NOX3 p.Glu365Asp Uncertain significance Single submitter
- NOX3 p.Glu460Lys Uncertain significance Single submitter
- NOX3 p.Gly174Val Uncertain significance Single submitter
- NOX3 p.Gly21Glu Uncertain significance Single submitter
- NOX3 p.Gly371Arg Uncertain significance Single submitter
- NOX3 p.Gly371Val Uncertain significance Single submitter
- NOX3 p.Gly390Glu Uncertain significance Single submitter
- NOX3 p.Gly558Ser Uncertain significance Single submitter
- NOX3 p.His220Gln Uncertain significance Single submitter
- NOX3 p.His549Tyr Uncertain significance Single submitter
- NOX3 p.Ile14Met Uncertain significance Single submitter
- NOX3 p.Ile284Phe Uncertain significance Single submitter
- NOX3 p.Ile46Val Uncertain significance Single submitter
- NOX3 p.Leu20Gln Uncertain significance Single submitter
- NOX3 p.Leu340Phe Uncertain significance Single submitter
- NOX3 p.Leu374Phe Uncertain significance Single submitter
- NOX3 p.Leu432Met Uncertain significance Single submitter
- NOX3 p.Lys468Arg Uncertain significance Single submitter
- NOX3 p.Met310Arg Uncertain significance Single submitter
- NOX3 p.Met547Thr Uncertain significance Single submitter
- NOX3 p.Met66Leu Uncertain significance Single submitter
- NOX3 p.Phe194Leu Uncertain significance Single submitter
- NOX3 p.Pro149Ser Uncertain significance Single submitter
- NOX3 p.Ser266Leu Uncertain significance Single submitter
- NOX3 p.Ser350Arg Uncertain significance Single submitter
- NOX3 p.Ser426Arg Uncertain significance Single submitter
- NOX3 p.Ser528Arg Uncertain significance Single submitter
- NOX3 p.Thr164Ile Uncertain significance Single submitter
- NOX3 p.Thr412Ala Uncertain significance Single submitter
- NOX3 p.Trp204Leu Uncertain significance Single submitter
- NOX3 p.Trp33Leu Uncertain significance Single submitter
- NOX3 p.Tyr42His Uncertain significance Single submitter
- NOX3 p.Val293Ile Uncertain significance Single submitter
Predictors split 24
The independent predictors disagree with each other — read with care.
- NOX3 p.Ala343Val Uncertain significance Single submitter
- NOX3 p.Ala58Ser Uncertain significance Single submitter
- NOX3 p.Arg158Trp Uncertain significance Single submitter
- NOX3 p.Arg245Cys Uncertain significance Single submitter
- NOX3 p.Arg55Gln Uncertain significance Single submitter
- NOX3 p.Cys86Tyr Uncertain significance Single submitter
- NOX3 p.Gln505Arg Uncertain significance Single submitter
- NOX3 p.Gly10Asp Uncertain significance Single submitter
- NOX3 p.Gly177Ser Uncertain significance Single submitter
- NOX3 p.Gly314Ala Uncertain significance Single submitter
- NOX3 p.Gly368Trp Uncertain significance Single submitter
- NOX3 p.His301Tyr Uncertain significance Single submitter
- NOX3 p.Ile187Thr Uncertain significance Single submitter
- NOX3 p.Ile442Met Uncertain significance Single submitter
- NOX3 p.Phe367Ser Uncertain significance Single submitter
- NOX3 p.Pro156Ser Uncertain significance Single submitter
- NOX3 p.Pro256Ser Uncertain significance Single submitter
- NOX3 p.Pro274Ser Uncertain significance Single submitter
- NOX3 p.Ser143Phe Uncertain significance Single submitter
- NOX3 p.Ser18Pro Uncertain significance Single submitter
- NOX3 p.Ser541Leu Uncertain significance Single submitter
- NOX3 p.Val293Ala Uncertain significance Single submitter
- NOX3 p.Val351Met Uncertain significance Single submitter
- NOX3 p.Val532Met Uncertain significance Single submitter
All NOX3 variants
Benign 1
- p.Gly531= Single submitter
Likely benign 4
- p.Arg462Gln Single submitter
- p.Glu365Lys Single submitter
- p.Leu324Phe Single submitter
- p.Thr222Met Single submitter
Uncertain significance 88
- p.Ala106Thr Single submitter ⚠
- p.Ala119Glu Single submitter ⚠
- p.Ala141Thr Single submitter ⚠
- p.Ala247Glu Single submitter ⚠
- p.Ala318Val Single submitter ⚠
- p.Ala343Val Single submitter ⚠
- p.Ala361Thr Single submitter ⚠
- p.Ala407Thr Single submitter ⚠
- p.Ala58Ser Single submitter ⚠
- p.Arg100Gly Single submitter ⚠
- p.Arg158Trp Single submitter ⚠
- p.Arg224Gln Single submitter ⚠
- p.Arg224Trp Single submitter ⚠
- p.Arg245Cys Single submitter ⚠
- p.Arg313Gly Single submitter ⚠
- p.Arg313His Single submitter ⚠
- p.Arg447Gly Single submitter ⚠
- p.Arg462Trp Single submitter ⚠
- p.Arg55Gln Single submitter ⚠
- p.Asn150Lys Single submitter ⚠
- p.Asn155Asp Single submitter ⚠
- p.Asn23Asp Single submitter ⚠
- p.Asp395Glu Single submitter ⚠
- p.Asp96His Single submitter ⚠
- p.Cys242Tyr Single submitter ⚠
- p.Cys280Arg Single submitter ⚠
- p.Cys443Phe Single submitter ⚠
- p.Cys65Arg Single submitter ⚠
- p.Cys86Tyr Single submitter ⚠
- p.Gln136Arg Single submitter ⚠
- p.Gln259Lys Single submitter ⚠
- p.Gln321Lys Single submitter ⚠
- p.Gln326Arg Single submitter ⚠
- p.Gln505Arg Single submitter ⚠
- p.Gln545Arg Single submitter ⚠
- p.Glu365Asp Single submitter ⚠
- p.Glu460Lys Single submitter ⚠
- p.Gly10Asp Single submitter ⚠
- p.Gly174Val Single submitter ⚠
- p.Gly177Ser Single submitter ⚠
- p.Gly21Glu Single submitter ⚠
- p.Gly314Ala Single submitter ⚠
- p.Gly368Trp Single submitter ⚠
- p.Gly371Arg Single submitter ⚠
- p.Gly371Val Single submitter ⚠
- p.Gly390Glu Single submitter ⚠
- p.Gly558Ser Single submitter ⚠
- p.His220Gln Single submitter ⚠
- p.His301Tyr Single submitter ⚠
- p.His549Tyr Single submitter ⚠
- p.Ile14Met Single submitter ⚠
- p.Ile187Thr Single submitter ⚠
- p.Ile284Phe Single submitter ⚠
- p.Ile442Met Single submitter ⚠
- p.Ile46Val Single submitter ⚠
- p.Leu20Gln Single submitter ⚠
- p.Leu340Phe Single submitter ⚠
- p.Leu374Phe Single submitter ⚠
- p.Leu432Met Single submitter ⚠
- p.Lys468Arg Single submitter ⚠
- p.Met310Arg Single submitter ⚠
- p.Met463Ile Single submitter
- p.Met547Thr Single submitter ⚠
- p.Met66Leu Single submitter ⚠
- p.Phe194Leu Single submitter ⚠
- p.Phe367Ser Single submitter ⚠
- p.Pro149Ser Single submitter ⚠
- p.Pro156Ser Single submitter ⚠
- p.Pro256Ser Single submitter ⚠
- p.Pro274Ser Single submitter ⚠
- p.Ser143Phe Single submitter ⚠
- p.Ser18Pro Single submitter ⚠
- p.Ser266Leu Single submitter ⚠
- p.Ser350Arg Single submitter ⚠
- p.Ser426Arg Single submitter ⚠
- p.Ser528Arg Single submitter ⚠
- p.Ser541Leu Single submitter ⚠
- p.Ser57Pro Single submitter
- p.Ser73Asn Single submitter
- p.Thr164Ile Single submitter ⚠
- p.Thr412Ala Single submitter ⚠
- p.Trp204Leu Single submitter ⚠
- p.Trp33Leu Single submitter ⚠
- p.Tyr42His Single submitter ⚠
- p.Val293Ala Single submitter ⚠
- p.Val293Ile Single submitter ⚠
- p.Val351Met Single submitter ⚠
- p.Val532Met Single submitter ⚠