NOXO1 — 96 ClinVar variants
All ClinVar germline NOXO1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 83 flagged for review →
9 Likely benign · 87 Uncertain significance
Full NOXO1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 83
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 71
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NOXO1 c.223+1G>C Uncertain significance Single submitter
- NOXO1 p.Ala208Ser Uncertain significance Single submitter
- NOXO1 p.Ala218Glu Uncertain significance Single submitter
- NOXO1 p.Ala242Thr Uncertain significance Single submitter
- NOXO1 p.Ala248Thr Uncertain significance Single submitter
- NOXO1 p.Ala278Val Uncertain significance Single submitter
- NOXO1 p.Ala293Thr Uncertain significance Single submitter
- NOXO1 p.Ala307Val Uncertain significance Single submitter
- NOXO1 p.Ala346Pro Uncertain significance Single submitter
- NOXO1 p.Ala346Thr Uncertain significance Single submitter
- NOXO1 p.Arg164Cys Uncertain significance Single submitter
- NOXO1 p.Arg177Gly Uncertain significance Single submitter
- NOXO1 p.Arg205Trp Uncertain significance Single submitter
- NOXO1 p.Arg224Leu Uncertain significance Single submitter
- NOXO1 p.Arg224Trp Uncertain significance Single submitter
- NOXO1 p.Arg241His Uncertain significance Single submitter
- NOXO1 p.Arg241Leu Uncertain significance Single submitter
- NOXO1 p.Arg258His Uncertain significance Single submitter
- NOXO1 p.Arg267Leu Uncertain significance Single submitter
- NOXO1 p.Arg277Leu Uncertain significance Single submitter
- NOXO1 p.Arg345Lys Uncertain significance Single submitter
- NOXO1 p.Arg353His Uncertain significance Single submitter
- NOXO1 p.Arg39Ser Uncertain significance Single submitter
- NOXO1 p.Arg5Gln Uncertain significance Single submitter
- NOXO1 p.Arg81Gly Uncertain significance Single submitter
- NOXO1 p.Arg84Gly Uncertain significance Single submitter
- NOXO1 p.Asp188His Uncertain significance Single submitter
- NOXO1 p.Asp35Glu Uncertain significance Single submitter
- NOXO1 p.Cys170Gly Uncertain significance Single submitter
- NOXO1 p.Cys238Ser Uncertain significance Single submitter
- NOXO1 p.Cys360Gly Uncertain significance Single submitter
- NOXO1 p.Gln184Leu Uncertain significance Single submitter
- NOXO1 p.Gln222Pro Uncertain significance Single submitter
- NOXO1 p.Gln47His Uncertain significance Single submitter
- NOXO1 p.Glu142Gly Uncertain significance Single submitter
- NOXO1 p.Glu143Gln Uncertain significance Single submitter
- NOXO1 p.Glu250Lys Uncertain significance Single submitter
- NOXO1 p.Gly133Ser Uncertain significance Single submitter
- NOXO1 p.Gly312Asp Uncertain significance Single submitter
- NOXO1 p.Gly355Asp Uncertain significance Single submitter
- NOXO1 p.Gly61Ser Uncertain significance Single submitter
- NOXO1 p.Gly88Ser Uncertain significance Single submitter
- NOXO1 p.Leu347Arg Uncertain significance Single submitter
- NOXO1 p.Leu78Gln Uncertain significance Single submitter
- NOXO1 p.Leu89Met Uncertain significance Single submitter
- NOXO1 p.Lys19Asn Uncertain significance Single submitter
- NOXO1 p.Phe118Cys Uncertain significance Single submitter
- NOXO1 p.Phe118Leu Uncertain significance Single submitter
- NOXO1 p.Pro128Ser Uncertain significance Single submitter
- NOXO1 p.Pro145Ser Uncertain significance Single submitter
- NOXO1 p.Pro178Thr Uncertain significance Single submitter
- NOXO1 p.Pro194Leu Uncertain significance Single submitter
- NOXO1 p.Pro324Arg Uncertain significance Single submitter
- NOXO1 p.Pro324Leu Uncertain significance Single submitter
- NOXO1 p.Pro77Ala Uncertain significance Single submitter
- NOXO1 p.Pro7Ser Uncertain significance Single submitter
- NOXO1 p.Ser240Cys Uncertain significance Single submitter
- NOXO1 p.Thr140Ile Uncertain significance Single submitter
- NOXO1 p.Thr171Asn Uncertain significance Single submitter
- NOXO1 p.Thr23Ala Uncertain significance Single submitter
- NOXO1 p.Thr23Met Uncertain significance Single submitter
- NOXO1 p.Thr328Ile Uncertain significance Single submitter
- NOXO1 p.Thr85Met Uncertain significance Single submitter
- NOXO1 p.Tyr243Asp Uncertain significance Single submitter
- NOXO1 p.Tyr274His Uncertain significance Single submitter
- NOXO1 p.Val109Leu Uncertain significance Single submitter
- NOXO1 p.Val136Leu Uncertain significance Single submitter
- NOXO1 p.Val28Met Uncertain significance Single submitter
- NOXO1 p.Val58Gly Uncertain significance Single submitter
- NOXO1 p.Val69Ala Uncertain significance Single submitter
- NOXO1 p.Val69Ile Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- NOXO1 p.Ala208Val Uncertain significance Single submitter
- NOXO1 p.Ala257Thr Uncertain significance Single submitter
- NOXO1 p.Arg108Leu Uncertain significance Single submitter
- NOXO1 p.Asp249Val Uncertain significance Single submitter
- NOXO1 p.Gly256Ala Uncertain significance Single submitter
- NOXO1 p.Ile335Thr Uncertain significance Single submitter
- NOXO1 p.Leu52Ile Uncertain significance Single submitter
- NOXO1 p.Phe169Cys Uncertain significance Single submitter
- NOXO1 p.Pro330His Uncertain significance Single submitter
- NOXO1 p.Ser112Arg Uncertain significance Single submitter
- NOXO1 p.Ser134Arg Uncertain significance Single submitter
- NOXO1 p.Trp269Leu Uncertain significance Single submitter
All NOXO1 variants
Likely benign 9
- p.Arg29His Single submitter
- p.Arg349Gln Single submitter
- p.Arg39His Single submitter
- p.Asp305Asn Single submitter
- p.Pro357Ser Single submitter
- p.Ser86Gly Single submitter
- p.Thr114Ala Single submitter
- p.Val342Ile Single submitter
- p.Leu262= No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
Uncertain significance 87
- c.223+1G>C Single submitter ⚠
- p.Ala208Ser Single submitter ⚠
- p.Ala208Val Single submitter ⚠
- p.Ala218Glu Single submitter ⚠
- p.Ala242Thr Single submitter ⚠
- p.Ala248Thr Single submitter ⚠
- p.Ala257Thr Single submitter ⚠
- p.Ala278Val Single submitter ⚠
- p.Ala293Thr Single submitter ⚠
- p.Ala307Val Single submitter ⚠
- p.Ala346Pro Single submitter ⚠
- p.Ala346Thr Single submitter ⚠
- p.Ala60Thr Single submitter
- p.Arg108Leu Single submitter ⚠
- p.Arg164Cys Single submitter ⚠
- p.Arg177Gly Single submitter ⚠
- p.Arg205Trp Single submitter ⚠
- p.Arg224Leu Single submitter ⚠
- p.Arg224Trp Single submitter ⚠
- p.Arg241His Single submitter ⚠
- p.Arg241Leu Single submitter ⚠
- p.Arg258His Single submitter ⚠
- p.Arg267Leu Single submitter ⚠
- p.Arg277Leu Single submitter ⚠
- p.Arg345Lys Single submitter ⚠
- p.Arg353His Single submitter ⚠
- p.Arg39Ser Single submitter ⚠
- p.Arg5Gln Single submitter ⚠
- p.Arg81Gly Single submitter ⚠
- p.Arg84Gly Single submitter ⚠
- p.Asp188His Single submitter ⚠
- p.Asp249Val Single submitter ⚠
- p.Asp35Glu Single submitter ⚠
- p.Cys170Gly Single submitter ⚠
- p.Cys238Ser Single submitter ⚠
- p.Cys360Gly Single submitter ⚠
- p.Gln184Leu Single submitter ⚠
- p.Gln222Pro Single submitter ⚠
- p.Gln47His Single submitter ⚠
- p.Glu142Gly Single submitter ⚠
- p.Glu143Gln Single submitter ⚠
- p.Glu250Lys Single submitter ⚠
- p.Gly133Ser Single submitter ⚠
- p.Gly256Ala Single submitter ⚠
- p.Gly279Ser Single submitter
- p.Gly312Asp Single submitter ⚠
- p.Gly355Asp Single submitter ⚠
- p.Gly61Ser Single submitter ⚠
- p.Gly88Ser Single submitter ⚠
- p.Ile335Thr Single submitter ⚠
- p.Leu347Arg Single submitter ⚠
- p.Leu52Ile Single submitter ⚠
- p.Leu78Gln Single submitter ⚠
- p.Leu89Met Single submitter ⚠
- p.Lys19Asn Single submitter ⚠
- p.Phe118Cys Single submitter ⚠
- p.Phe118Leu Single submitter ⚠
- p.Phe169Cys Single submitter ⚠
- p.Pro128Ser Single submitter ⚠
- p.Pro145Ser Single submitter ⚠
- p.Pro178Thr Single submitter ⚠
- p.Pro194Leu Single submitter ⚠
- p.Pro324Arg Single submitter ⚠
- p.Pro324Leu Single submitter ⚠
- p.Pro330His Single submitter ⚠
- p.Pro77Ala Single submitter ⚠
- p.Pro7Ser Single submitter ⚠
- p.Ser112Arg Single submitter ⚠
- p.Ser134Arg Single submitter ⚠
- p.Ser240Cys Single submitter ⚠
- p.Thr140Ile Single submitter ⚠
- p.Thr171Asn Single submitter ⚠
- p.Thr23Ala Single submitter ⚠
- p.Thr23Met Single submitter ⚠
- p.Thr328Ile Single submitter ⚠
- p.Thr85Met Single submitter ⚠
- p.Trp269Leu Single submitter ⚠
- p.Tyr243Asp Single submitter ⚠
- p.Tyr274His Single submitter ⚠
- p.Val109Leu Single submitter ⚠
- p.Val136Leu Single submitter ⚠
- p.Val189Met Single submitter
- p.Val261Leu Single submitter
- p.Val28Met Single submitter ⚠
- p.Val58Gly Single submitter ⚠
- p.Val69Ala Single submitter ⚠
- p.Val69Ile Single submitter ⚠