NUDCD3 — 46 ClinVar variants
All ClinVar germline NUDCD3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 45 flagged for review →
1 Likely pathogenic · 45 Uncertain significance
Full NUDCD3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 45
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- NUDCD3 p.Ala103Thr Uncertain significance Single submitter
- NUDCD3 p.Ala103Val Uncertain significance Single submitter
- NUDCD3 p.Ala159Pro Uncertain significance Single submitter
- NUDCD3 p.Ala303Thr Uncertain significance Single submitter
- NUDCD3 p.Ala5Ser Uncertain significance Single submitter
- NUDCD3 p.Ala6Val Uncertain significance Single submitter
- NUDCD3 p.Arg235His Uncertain significance Single submitter
- NUDCD3 p.Arg292Gly Uncertain significance Single submitter
- NUDCD3 p.Arg292His Uncertain significance Single submitter
- NUDCD3 p.Arg346Gln Uncertain significance Single submitter
- NUDCD3 p.Arg45His Uncertain significance Single submitter
- NUDCD3 p.Arg74His Uncertain significance Single submitter
- NUDCD3 p.Asn232Asp Uncertain significance Single submitter
- NUDCD3 p.Asp284Asn Uncertain significance Single submitter
- NUDCD3 p.Gln134His Uncertain significance Single submitter
- NUDCD3 p.Glu278Lys Uncertain significance Single submitter
- NUDCD3 p.Glu281Lys Uncertain significance Single submitter
- NUDCD3 p.Glu338Ala Uncertain significance Single submitter
- NUDCD3 p.Glu93Lys Uncertain significance Single submitter
- NUDCD3 p.Glu94Lys Uncertain significance Single submitter
- NUDCD3 p.Glu95Lys Uncertain significance Single submitter
- NUDCD3 p.Gly344Ser Uncertain significance Single submitter
- NUDCD3 p.Met238Thr Uncertain significance Single submitter
- NUDCD3 p.Met294Val Uncertain significance Single submitter
- NUDCD3 p.Phe40Leu Uncertain significance Single submitter
- NUDCD3 p.Pro165Leu Uncertain significance Single submitter
- NUDCD3 p.Pro320Leu Uncertain significance Single submitter
- NUDCD3 p.Thr121Ile Uncertain significance Single submitter
- NUDCD3 p.Tyr41Cys Uncertain significance Single submitter
- NUDCD3 p.Val113Gly Uncertain significance Single submitter
- NUDCD3 p.Val236Ile Uncertain significance Single submitter
- NUDCD3 p.Val261Ile Uncertain significance Single submitter
- NUDCD3 p.Val297Met Uncertain significance Single submitter
- NUDCD3 p.Val304Met Uncertain significance Single submitter
- NUDCD3 p.Val65Ile Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- NUDCD3 p.Arg42Leu Uncertain significance Single submitter
- NUDCD3 p.Arg74Cys Uncertain significance Single submitter
- NUDCD3 p.Asn189Ile Uncertain significance Single submitter
- NUDCD3 p.Asn22Ser Uncertain significance Single submitter
- NUDCD3 p.Glu249Gly Uncertain significance Single submitter
- NUDCD3 p.Gly357Glu Uncertain significance Single submitter
- NUDCD3 p.Gly357Trp Uncertain significance Single submitter
- NUDCD3 p.Leu13Phe Uncertain significance Single submitter
- NUDCD3 p.Leu199Met Uncertain significance Single submitter
- NUDCD3 p.Met351Thr Uncertain significance Single submitter
All NUDCD3 variants
Likely pathogenic 1
- p.His313Pro Single submitter
Uncertain significance 45
- p.Ala103Thr Single submitter ⚠
- p.Ala103Val Single submitter ⚠
- p.Ala159Pro Single submitter ⚠
- p.Ala303Thr Single submitter ⚠
- p.Ala5Ser Single submitter ⚠
- p.Ala6Val Single submitter ⚠
- p.Arg235His Single submitter ⚠
- p.Arg292Gly Single submitter ⚠
- p.Arg292His Single submitter ⚠
- p.Arg346Gln Single submitter ⚠
- p.Arg42Leu Single submitter ⚠
- p.Arg45His Single submitter ⚠
- p.Arg74Cys Single submitter ⚠
- p.Arg74His Single submitter ⚠
- p.Asn189Ile Single submitter ⚠
- p.Asn22Ser Single submitter ⚠
- p.Asn232Asp Single submitter ⚠
- p.Asp284Asn Single submitter ⚠
- p.Gln134His Single submitter ⚠
- p.Glu249Gly Single submitter ⚠
- p.Glu278Lys Single submitter ⚠
- p.Glu281Lys Single submitter ⚠
- p.Glu338Ala Single submitter ⚠
- p.Glu93Lys Single submitter ⚠
- p.Glu94Lys Single submitter ⚠
- p.Glu95Lys Single submitter ⚠
- p.Gly344Ser Single submitter ⚠
- p.Gly357Glu Single submitter ⚠
- p.Gly357Trp Single submitter ⚠
- p.Leu13Phe Single submitter ⚠
- p.Leu199Met Single submitter ⚠
- p.Met238Thr Single submitter ⚠
- p.Met294Val Single submitter ⚠
- p.Met351Thr Single submitter ⚠
- p.Phe40Leu Single submitter ⚠
- p.Pro165Leu Single submitter ⚠
- p.Pro320Leu Single submitter ⚠
- p.Thr121Ile Single submitter ⚠
- p.Tyr41Cys Single submitter ⚠
- p.Val113Gly Single submitter ⚠
- p.Val236Ile Single submitter ⚠
- p.Val261Ile Single submitter ⚠
- p.Val297Met Single submitter ⚠
- p.Val304Met Single submitter ⚠
- p.Val65Ile Single submitter ⚠