NXT2 — 6 ClinVar variants
All ClinVar germline NXT2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 2 flagged for review →
1 Likely pathogenic · 2 Likely benign · 3 Uncertain significance
Full NXT2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 2
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 2
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
All NXT2 variants
Likely pathogenic 1
- p.Asp64Ter Single submitter male infertility
Likely benign 2
- p.Gly15Arg Single submitter
- p.Asn124Ser No assertion criteria NXT2-related condition
Uncertain significance 3
- p.Ala118Ser Single submitter ⚠
- p.Ala35Ser Single submitter male infertility ⚠
- p.Ser20Cys Single submitter