OGG1 — 55 ClinVar variants
All ClinVar germline OGG1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 37 flagged for review →
2 Benign · 11 Likely benign · 42 Uncertain significance
Full OGG1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 37
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- OGG1 p.Ala21Ser Uncertain significance Single submitter
- OGG1 p.Ala334Val Uncertain significance Single submitter
- OGG1 p.Arg134Leu Uncertain significance Single submitter
- OGG1 p.Arg213Gln Uncertain significance Single submitter
- OGG1 p.Arg304Gln Uncertain significance Single submitter
- OGG1 p.Arg46Trp Uncertain significance Single submitter
- OGG1 p.Arg79Gly Uncertain significance Single submitter
- OGG1 p.Asp103Glu Uncertain significance Single submitter
- OGG1 p.Gln219Arg Uncertain significance Single submitter
- OGG1 p.Gln43Leu Uncertain significance Single submitter
- OGG1 p.Glu193Gly Uncertain significance Single submitter
- OGG1 p.Gly114Asp Uncertain significance Single submitter
- OGG1 p.Gly42Glu Uncertain significance Single submitter
- OGG1 p.His328Tyr Uncertain significance Single submitter
- OGG1 p.Ile155Thr Uncertain significance Single submitter
- OGG1 p.Leu216Met Uncertain significance Single submitter
- OGG1 p.Leu240Val Uncertain significance Single submitter
- OGG1 p.Leu66Val Uncertain significance Single submitter
- OGG1 p.Lys238Thr Uncertain significance Single submitter
- OGG1 p.Lys98Arg Uncertain significance Single submitter
- OGG1 p.Met271Arg Uncertain significance Single submitter
- OGG1 p.Pro291Leu Uncertain significance Single submitter
- OGG1 p.Ser280Asn Uncertain significance Single submitter
- OGG1 p.Ser31Cys Uncertain significance Single submitter
- OGG1 p.Ser44Pro Uncertain significance Single submitter
- OGG1 p.Thr177Ser Uncertain significance Single submitter
- OGG1 p.Thr69Ala Uncertain significance Single submitter
- OGG1 p.Val123Leu Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- OGG1 p.Arg336Cys Uncertain significance Single submitter
- OGG1 p.Asn149Ser Uncertain significance Single submitter
- OGG1 p.Asp136Asn Uncertain significance Single submitter
- OGG1 p.Glu160Gly Uncertain significance Single submitter
- OGG1 p.His111Tyr Uncertain significance Single submitter
- OGG1 p.Pro190Arg Uncertain significance Single submitter
- OGG1 p.Pro190Leu Uncertain significance Single submitter
- OGG1 p.Pro88His Uncertain significance Single submitter
- OGG1 p.Ser320Arg Uncertain significance Single submitter
All OGG1 variants
Benign 2
- c.949-5T>C Multiple submitters
- p.Ser326Cys No assertion criteria OGG1-related disorder
Likely benign 11
- c.948+7G>A Single submitter
- p.Gly308Glu Single submitter
- p.Gly348Glu Single submitter nonpapillary renal cell carcinoma
- p.His328Arg Single submitter
- p.Ile242Thr Single submitter
- p.Ser118Pro Single submitter
- p.Thr285= Single submitter
- c.748-9C>T No assertion criteria OGG1-related disorder
- p.His328= No assertion criteria OGG1-related disorder
- p.Leu359Phe No assertion criteria OGG1-related disorder
- p.Val58= No assertion criteria OGG1-related disorder
Uncertain significance 42
- p.Ala21Ser Single submitter ⚠
- p.Ala334Val Single submitter ⚠
- p.Ala400Thr Single submitter
- p.Arg134Gly Single submitter
- p.Arg134Leu Single submitter ⚠
- p.Arg213Gln Single submitter ⚠
- p.Arg304Gln Single submitter ⚠
- p.Arg336Cys Single submitter ⚠
- p.Arg46Gln Single submitter clear cell renal carcinoma
- p.Arg46Trp Single submitter ⚠
- p.Arg79Gly Single submitter ⚠
- p.Asn149Ser Single submitter ⚠
- p.Asp103Glu Single submitter ⚠
- p.Asp136Asn Single submitter ⚠
- p.Gln219Arg Single submitter ⚠
- p.Gln43Leu Single submitter ⚠
- p.Glu160Gly Single submitter ⚠
- p.Glu193Gly Single submitter ⚠
- p.Gly114Asp Single submitter ⚠
- p.Gly42Glu Single submitter ⚠
- p.His111Tyr Single submitter ⚠
- p.His328Tyr Single submitter ⚠
- p.Ile155Thr Single submitter ⚠
- p.Leu216Met Single submitter ⚠
- p.Leu240Val Single submitter ⚠
- p.Leu66Val Single submitter ⚠
- p.Lys238Thr Single submitter ⚠
- p.Lys98Arg Single submitter ⚠
- p.Met271Arg Single submitter ⚠
- p.Pro190Arg Single submitter ⚠
- p.Pro190Leu Single submitter ⚠
- p.Pro291Leu Single submitter ⚠
- p.Pro88His Single submitter ⚠
- p.Ser280Asn Single submitter ⚠
- p.Ser31Cys Single submitter ⚠
- p.Ser320Arg Single submitter ⚠
- p.Ser44Pro Single submitter ⚠
- p.Thr177Ser Single submitter ⚠
- p.Thr69Ala Single submitter ⚠
- p.Tyr110His Single submitter
- p.Val123Leu Single submitter ⚠
- p.Val267Leu Single submitter