OMP — 35 ClinVar variants
All ClinVar germline OMP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
4 Likely benign · 31 Uncertain significance
Full OMP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 20
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- OMP p.Ala156Val Uncertain significance Single submitter
- OMP p.Ala2Val Uncertain significance Single submitter
- OMP p.Ala49Glu Uncertain significance Single submitter
- OMP p.Arg26Gln Uncertain significance Single submitter
- OMP p.Arg26Leu Uncertain significance Single submitter
- OMP p.Arg39Cys Uncertain significance Single submitter
- OMP p.Arg39His Uncertain significance Single submitter
- OMP p.Asp90Ala Uncertain significance Single submitter
- OMP p.Gln7Arg Uncertain significance Single submitter
- OMP p.Glu66Lys Uncertain significance Single submitter
- OMP p.Leu154Phe Uncertain significance Single submitter
- OMP p.Leu163Pro Uncertain significance Single submitter
- OMP p.Phe65Ser Uncertain significance Single submitter
- OMP p.Thr22Ser Uncertain significance Single submitter
- OMP p.Thr81Ile Uncertain significance Single submitter
- OMP p.Val143Phe Uncertain significance Single submitter
- OMP p.Val158Met Uncertain significance Single submitter
- OMP p.Val16Leu Uncertain significance Single submitter
- OMP p.Val16Phe Uncertain significance Single submitter
- OMP p.Val71Met Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- OMP p.Arg108Cys Uncertain significance Single submitter
- OMP p.Arg35Cys Uncertain significance Single submitter
- OMP p.Arg62Trp Uncertain significance Single submitter
- OMP p.Arg67Cys Uncertain significance Single submitter
- OMP p.Arg97Cys Uncertain significance Single submitter
- OMP p.Asn86Lys Uncertain significance Single submitter
- OMP p.Leu91Phe Uncertain significance Single submitter
- OMP p.Lys137Asn Uncertain significance Single submitter
- OMP p.Pro14Leu Uncertain significance Single submitter
All OMP variants
Likely benign 4
- p.Ala152Thr Single submitter
- p.Arg26= Single submitter
- p.Val143Ile Single submitter
- p.Val29Met Single submitter
Uncertain significance 31
- p.Ala156Val Single submitter ⚠
- p.Ala2Val Single submitter ⚠
- p.Ala49Glu Single submitter ⚠
- p.Arg108Cys Single submitter ⚠
- p.Arg26Gln Single submitter ⚠
- p.Arg26Leu Single submitter ⚠
- p.Arg28Cys Single submitter
- p.Arg35Cys Single submitter ⚠
- p.Arg39Cys Single submitter ⚠
- p.Arg39His Single submitter ⚠
- p.Arg62Trp Single submitter ⚠
- p.Arg67Cys Single submitter ⚠
- p.Arg97Cys Single submitter ⚠
- p.Asn86Lys Single submitter ⚠
- p.Asp90Ala Single submitter ⚠
- p.Gln7Arg Single submitter ⚠
- p.Glu66Lys Single submitter ⚠
- p.Leu154Phe Single submitter ⚠
- p.Leu163Pro Single submitter ⚠
- p.Leu91Phe Single submitter ⚠
- p.Lys137Asn Single submitter ⚠
- p.Phe65Ser Single submitter ⚠
- p.Pro14Leu Single submitter ⚠
- p.Pro151Arg Single submitter
- p.Thr22Ser Single submitter ⚠
- p.Thr81Ile Single submitter ⚠
- p.Val143Phe Single submitter ⚠
- p.Val158Met Single submitter ⚠
- p.Val16Leu Single submitter ⚠
- p.Val16Phe Single submitter ⚠
- p.Val71Met Single submitter ⚠