ORAI2 — 37 ClinVar variants
All ClinVar germline ORAI2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
1 Benign · 1 Likely benign · 35 Uncertain significance
Full ORAI2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ORAI2 p.Ala13Val Uncertain significance Single submitter
- ORAI2 p.Ala99Thr Uncertain significance Single submitter
- ORAI2 p.Arg179Trp Uncertain significance Single submitter
- ORAI2 p.Arg220His Uncertain significance Single submitter
- ORAI2 p.Arg229Cys Uncertain significance Single submitter
- ORAI2 p.Arg91Gln Uncertain significance Single submitter
- ORAI2 p.Asn231Lys Uncertain significance Single submitter
- ORAI2 p.Asp10Asn Uncertain significance Single submitter
- ORAI2 p.Gln195Leu Uncertain significance Single submitter
- ORAI2 p.Glu147Lys Uncertain significance Single submitter
- ORAI2 p.Glu164Lys Uncertain significance Single submitter
- ORAI2 p.Gly20Asp Uncertain significance Single submitter
- ORAI2 p.Gly20Ser Uncertain significance Single submitter
- ORAI2 p.Gly72Ser Uncertain significance Single submitter
- ORAI2 p.Ile210Val Uncertain significance Single submitter
- ORAI2 p.Leu209Val Uncertain significance Single submitter
- ORAI2 p.Leu48Val Uncertain significance Single submitter
- ORAI2 p.Lys22Glu Uncertain significance Single submitter
- ORAI2 p.Met24Leu Uncertain significance Single submitter
- ORAI2 p.Pro138Leu Uncertain significance Single submitter
- ORAI2 p.Pro185Gln Uncertain significance Single submitter
- ORAI2 p.Pro19Arg Uncertain significance Single submitter
- ORAI2 p.Ser49Leu Uncertain significance Single submitter
- ORAI2 p.Thr154Asn Uncertain significance Single submitter
- ORAI2 p.Thr192Met Uncertain significance Single submitter
- ORAI2 p.Thr201Ala Uncertain significance Single submitter
- ORAI2 p.Thr39Ala Uncertain significance Single submitter
- ORAI2 p.Val176Met Uncertain significance Single submitter
- ORAI2 p.Val212Met Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All ORAI2 variants
Benign 1
- p.Ser67= Multiple submitters
Likely benign 1
- p.Pro17Ser Single submitter
Uncertain significance 35
- p.Ala13Val Single submitter ⚠
- p.Ala99Thr Single submitter ⚠
- p.Arg179Trp Single submitter ⚠
- p.Arg220His Single submitter ⚠
- p.Arg229Cys Single submitter ⚠
- p.Arg91Gln Single submitter ⚠
- p.Asn231Lys Single submitter ⚠
- p.Asp10Asn Single submitter ⚠
- p.Asp25Gly Single submitter
- p.Gln195Leu Single submitter ⚠
- p.Glu147Lys Single submitter ⚠
- p.Glu164Lys Single submitter ⚠
- p.Gly193Asp Single submitter ⚠
- p.Gly20Asp Single submitter ⚠
- p.Gly20Ser Single submitter ⚠
- p.Gly72Ser Single submitter ⚠
- p.Ile210Val Single submitter ⚠
- p.Leu209Val Single submitter ⚠
- p.Leu48Val Single submitter ⚠
- p.Lys22Glu Single submitter ⚠
- p.Lys52Gln Single submitter ⚠
- p.Met204Ile Single submitter ⚠
- p.Met24Leu Single submitter ⚠
- p.Pro138Leu Single submitter ⚠
- p.Pro185Gln Single submitter ⚠
- p.Pro19Arg Single submitter ⚠
- p.Pro92Arg Single submitter ⚠
- p.Ser49Leu Single submitter ⚠
- p.Thr154Asn Single submitter ⚠
- p.Thr192Met Single submitter ⚠
- p.Thr201Ala Single submitter ⚠
- p.Thr39Ala Single submitter ⚠
- p.Tyr26Ser Single submitter ⚠
- p.Val176Met Single submitter ⚠
- p.Val212Met Single submitter ⚠