ORC3 — 107 ClinVar variants
All ClinVar germline ORC3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 95 flagged for review →
2 Likely pathogenic · 6 Likely benign · 99 Uncertain significance
Full ORC3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 95
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 79
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ORC3 p.Ala586Gly Uncertain significance Single submitter
- ORC3 p.Ala594Val Uncertain significance Single submitter
- ORC3 p.Arg204Ser Uncertain significance Single submitter
- ORC3 p.Arg353Gly Uncertain significance Single submitter
- ORC3 p.Arg367Gln Uncertain significance Single submitter
- ORC3 p.Arg368His Uncertain significance Single submitter
- ORC3 p.Arg392Lys Uncertain significance Single submitter
- ORC3 p.Arg436Lys Uncertain significance Single submitter
- ORC3 p.Arg588Cys Uncertain significance Single submitter
- ORC3 p.Arg588His Uncertain significance Single submitter
- ORC3 p.Asn110Ile Uncertain significance Single submitter
- ORC3 p.Asn127Asp Uncertain significance Single submitter
- ORC3 p.Asn16Thr Uncertain significance Single submitter
- ORC3 p.Asn31Ile Uncertain significance Single submitter
- ORC3 p.Asn323Thr Uncertain significance Single submitter
- ORC3 p.Asn390Ser Uncertain significance Single submitter
- ORC3 p.Asn404Lys Uncertain significance Single submitter
- ORC3 p.Asn604His Uncertain significance Single submitter
- ORC3 p.Asn605Ser Uncertain significance Single submitter
- ORC3 p.Asn68Asp Uncertain significance Single submitter
- ORC3 p.Asp290Asn Uncertain significance Single submitter
- ORC3 p.Asp647His Uncertain significance Single submitter
- ORC3 p.Cys141Tyr Uncertain significance Single submitter
- ORC3 p.Cys475Ser Uncertain significance Single submitter
- ORC3 p.Cys621Tyr Uncertain significance Single submitter
- ORC3 p.Gln379Leu Uncertain significance Single submitter
- ORC3 p.Gln530Arg Uncertain significance Single submitter
- ORC3 p.Glu168Gly Uncertain significance Single submitter
- ORC3 p.Glu283Lys Uncertain significance Single submitter
- ORC3 p.Glu334Asp Uncertain significance Single submitter
- ORC3 p.Glu45Lys Uncertain significance Single submitter
- ORC3 p.Glu535Gly Uncertain significance Single submitter
- ORC3 p.Glu619Lys Uncertain significance Single submitter
- ORC3 p.Gly119Ala Uncertain significance Single submitter
- ORC3 p.Gly119Glu Uncertain significance Single submitter
- ORC3 p.Gly83Arg Uncertain significance Single submitter
- ORC3 p.Gly93Ser Uncertain significance Single submitter
- ORC3 p.His146Arg Uncertain significance Single submitter
- ORC3 p.His265Arg Uncertain significance Single submitter
- ORC3 p.His406Asn Uncertain significance Single submitter
- ORC3 p.His406Tyr Uncertain significance Single submitter
- ORC3 p.His420Gln Uncertain significance Single submitter
- ORC3 p.His636Gln Uncertain significance Single submitter
- ORC3 p.Ile252Lys Uncertain significance Single submitter
- ORC3 p.Ile643Ser Uncertain significance Single submitter
- ORC3 p.Leu387Pro Uncertain significance Single submitter
- ORC3 p.Leu529Pro Uncertain significance Single submitter
- ORC3 p.Leu551Val Uncertain significance Single submitter
- ORC3 p.Lys139Glu Uncertain significance Single submitter
- ORC3 p.Lys480Thr Uncertain significance Single submitter
- ORC3 p.Lys55Asn Uncertain significance Single submitter
- ORC3 p.Lys661Arg Uncertain significance Single submitter
- ORC3 p.Lys67Glu Uncertain significance Single submitter
- ORC3 p.Met181Val Uncertain significance Single submitter
- ORC3 p.Met469Thr Uncertain significance Single submitter
- ORC3 p.Met6Ile Uncertain significance Single submitter
- ORC3 p.Pro142Leu Uncertain significance Single submitter
- ORC3 p.Pro15Ser Uncertain significance Single submitter
- ORC3 p.Pro340Leu Uncertain significance Single submitter
- ORC3 p.Ser120Thr Uncertain significance Single submitter
- ORC3 p.Ser17Thr Uncertain significance Single submitter
- ORC3 p.Ser532Tyr Uncertain significance Single submitter
- ORC3 p.Ser649Leu Uncertain significance Single submitter
- ORC3 p.Ser7Cys Uncertain significance Single submitter
- ORC3 p.Ser82Cys Uncertain significance Single submitter
- ORC3 p.Ser88Leu Uncertain significance Single submitter
- ORC3 p.Thr195Met Uncertain significance Single submitter
- ORC3 p.Thr668Ala Uncertain significance Single submitter
- ORC3 p.Trp448Gly Uncertain significance Single submitter
- ORC3 p.Trp51Arg Uncertain significance Single submitter
- ORC3 p.Tyr179His Uncertain significance Single submitter
- ORC3 p.Tyr29Cys Uncertain significance Single submitter
- ORC3 p.Tyr393His Uncertain significance Single submitter
- ORC3 p.Tyr429Cys Uncertain significance Single submitter
- ORC3 p.Val12Ala Uncertain significance Single submitter
- ORC3 p.Val12Phe Uncertain significance Single submitter
- ORC3 p.Val172Ile Uncertain significance Single submitter
- ORC3 p.Val288Ile Uncertain significance Single submitter
- ORC3 p.Val579Ala Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- ORC3 p.Arg679Gln Uncertain significance Single submitter
- ORC3 p.Asn66Asp Uncertain significance Single submitter
- ORC3 p.Cys141Gly Uncertain significance Single submitter
- ORC3 p.Cys281Tyr Uncertain significance Single submitter
- ORC3 p.His576Leu Uncertain significance Single submitter
- ORC3 p.Ile435Asn Uncertain significance Single submitter
- ORC3 p.Ile676Ser Uncertain significance Single submitter
- ORC3 p.Met536Ile Uncertain significance Single submitter
- ORC3 p.Phe233Leu Uncertain significance Single submitter
- ORC3 p.Phe44Leu Uncertain significance Single submitter
- ORC3 p.Phe497Leu Uncertain significance Single submitter
- ORC3 p.Pro264Ala Uncertain significance Single submitter
- ORC3 p.Pro430Leu Uncertain significance Single submitter
- ORC3 p.Ser7Phe Uncertain significance Single submitter
- ORC3 p.Thr102Ile Uncertain significance Single submitter
- ORC3 p.Trp448Arg Uncertain significance Single submitter
All ORC3 variants
Likely pathogenic 2
- c.873+4A>G No assertion criteria ORC3-related disorder
- p.Val216Asp No assertion criteria ORC3-related disorder
Likely benign 6
- p.Ala667Thr Single submitter
- p.Arg374= Single submitter
- p.Arg493Lys Single submitter
- p.Gly119Arg Single submitter
- p.Pro518Ser Single submitter
- p.Val309Ile Single submitter
Uncertain significance 99
- p.Ala103Val Single submitter
- p.Ala586Gly Single submitter ⚠
- p.Ala594Val Single submitter ⚠
- p.Arg204Ser Single submitter ⚠
- p.Arg353Gly Single submitter ⚠
- p.Arg367Gln Single submitter ⚠
- p.Arg368His Single submitter ⚠
- p.Arg392Lys Single submitter ⚠
- p.Arg436Lys Single submitter ⚠
- p.Arg588Cys Single submitter ⚠
- p.Arg588His Single submitter ⚠
- p.Arg679Gln Single submitter ⚠
- p.Asn110Ile Single submitter ⚠
- p.Asn127Asp Single submitter ⚠
- p.Asn16Thr Single submitter ⚠
- p.Asn31Ile Single submitter ⚠
- p.Asn323Thr Single submitter ⚠
- p.Asn390Ser Single submitter ⚠
- p.Asn404Lys Single submitter ⚠
- p.Asn604His Single submitter ⚠
- p.Asn605Ser Single submitter ⚠
- p.Asn66Asp Single submitter ⚠
- p.Asn68Asp Single submitter ⚠
- p.Asp221Gly Single submitter
- p.Asp290Asn Single submitter ⚠
- p.Asp647His Single submitter ⚠
- p.Cys141Gly Single submitter ⚠
- p.Cys141Tyr Single submitter ⚠
- p.Cys281Tyr Single submitter ⚠
- p.Cys475Ser Single submitter ⚠
- p.Cys621Tyr Single submitter ⚠
- p.Gln379Leu Single submitter ⚠
- p.Gln530Arg Single submitter ⚠
- p.Glu168Gly Single submitter ⚠
- p.Glu283Lys Single submitter ⚠
- p.Glu334Asp Single submitter ⚠
- p.Glu45Lys Single submitter ⚠
- p.Glu535Gly Single submitter ⚠
- p.Glu619Lys Single submitter ⚠
- p.Gly119Ala Single submitter ⚠
- p.Gly119Glu Single submitter ⚠
- p.Gly83Arg Single submitter ⚠
- p.Gly93Ser Single submitter ⚠
- p.His146Arg Single submitter ⚠
- p.His265Arg Single submitter ⚠
- p.His406Asn Single submitter ⚠
- p.His406Tyr Single submitter ⚠
- p.His420Gln Single submitter ⚠
- p.His576Leu Single submitter ⚠
- p.His600Arg Single submitter
- p.His636Gln Single submitter ⚠
- p.Ile252Lys Single submitter ⚠
- p.Ile435Asn Single submitter ⚠
- p.Ile643Ser Single submitter ⚠
- p.Ile676Ser Single submitter ⚠
- p.Leu387Pro Single submitter ⚠
- p.Leu529Pro Single submitter ⚠
- p.Leu551Val Single submitter ⚠
- p.Lys139Glu Single submitter ⚠
- p.Lys480Thr Single submitter ⚠
- p.Lys55Asn Single submitter ⚠
- p.Lys661Arg Single submitter ⚠
- p.Lys67Glu Single submitter ⚠
- p.Met181Val Single submitter ⚠
- p.Met469Thr Single submitter ⚠
- p.Met536Ile Single submitter ⚠
- p.Met6Ile Single submitter ⚠
- p.Phe233Leu Single submitter ⚠
- p.Phe44Leu Single submitter ⚠
- p.Phe497Leu Single submitter ⚠
- p.Pro142Leu Single submitter ⚠
- p.Pro15Ser Single submitter ⚠
- p.Pro264Ala Single submitter ⚠
- p.Pro340Leu Single submitter ⚠
- p.Pro430Leu Single submitter ⚠
- p.Pro595Leu Single submitter
- p.Ser120Thr Single submitter ⚠
- p.Ser17Thr Single submitter ⚠
- p.Ser532Tyr Single submitter ⚠
- p.Ser649Leu Single submitter ⚠
- p.Ser7Cys Single submitter ⚠
- p.Ser7Phe Single submitter ⚠
- p.Ser82Cys Single submitter ⚠
- p.Ser88Leu Single submitter ⚠
- p.Thr102Ile Single submitter ⚠
- p.Thr195Met Single submitter ⚠
- p.Thr668Ala Single submitter ⚠
- p.Trp448Arg Single submitter ⚠
- p.Trp448Gly Single submitter ⚠
- p.Trp51Arg Single submitter ⚠
- p.Tyr179His Single submitter ⚠
- p.Tyr29Cys Single submitter ⚠
- p.Tyr393His Single submitter ⚠
- p.Tyr429Cys Single submitter ⚠
- p.Val12Ala Single submitter ⚠
- p.Val12Phe Single submitter ⚠
- p.Val172Ile Single submitter ⚠
- p.Val288Ile Single submitter ⚠
- p.Val579Ala Single submitter ⚠