P2RY10 — 24 ClinVar variants
All ClinVar germline P2RY10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 21 flagged for review →
1 Benign · 1 Likely benign · 22 Uncertain significance
Full P2RY10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 21
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 18
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- P2RY10 p.Ala104Thr Uncertain significance Single submitter
- P2RY10 p.Ala215Ser Uncertain significance Single submitter
- P2RY10 p.Ala250Val Uncertain significance Single submitter
- P2RY10 p.Arg313His Uncertain significance Single submitter
- P2RY10 p.Asn177Ser Uncertain significance Single submitter
- P2RY10 p.Ile235Phe Uncertain significance Single submitter
- P2RY10 p.Ile264Val Uncertain significance Single submitter
- P2RY10 p.Leu105Phe Uncertain significance Single submitter
- P2RY10 p.Leu115Val Uncertain significance Single submitter
- P2RY10 p.Ser53Ile Uncertain significance Single submitter
- P2RY10 p.Thr18Ala Uncertain significance Single submitter
- P2RY10 p.Thr18Asn Uncertain significance Single submitter
- P2RY10 p.Thr267Ala Uncertain significance Single submitter
- P2RY10 p.Tyr37Phe Uncertain significance Single submitter
- P2RY10 p.Val150Leu Uncertain significance Single submitter
- P2RY10 p.Val159Phe Uncertain significance Single submitter
- P2RY10 p.Val201Leu Uncertain significance Single submitter
- P2RY10 p.Val30Leu Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All P2RY10 variants
Benign 1
- p.Cys132= Multiple submitters
Likely benign 1
- p.Arg140= Single submitter
Uncertain significance 22
- p.Ala104Thr Single submitter ⚠
- p.Ala215Ser Single submitter ⚠
- p.Ala250Val Single submitter ⚠
- p.Ala55Gly Single submitter
- p.Arg313His Single submitter ⚠
- p.Arg90Trp Single submitter ⚠
- p.Asn177Ser Single submitter ⚠
- p.Ile235Phe Single submitter ⚠
- p.Ile264Val Single submitter ⚠
- p.Leu105Phe Single submitter ⚠
- p.Leu115Val Single submitter ⚠
- p.Leu304Phe Single submitter ⚠
- p.Met117Thr Single submitter ⚠
- p.Ser53Ile Single submitter ⚠
- p.Thr18Ala Single submitter ⚠
- p.Thr18Asn Single submitter ⚠
- p.Thr267Ala Single submitter ⚠
- p.Tyr37Phe Single submitter ⚠
- p.Val150Leu Single submitter ⚠
- p.Val159Phe Single submitter ⚠
- p.Val201Leu Single submitter ⚠
- p.Val30Leu Single submitter ⚠